Patents by Inventor Hisashi Hirano

Hisashi Hirano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11604194
    Abstract: The present invention aims to provide a method for simply and highly accurately detecting castration-resistant prostate cancer (CRPC), and a reagent that can be used for this method. By measuring the level of GDF15 propeptide present in a sample as a novel detection marker for CRPC, acquisition of castration resistance in a prostate cancer patient during or after endocrine therapy is detected. An antibody that specifically recognizes GDF15 propeptide is included in the CRPC detection reagent.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: March 14, 2023
    Assignees: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, TOSOH CORPORATION
    Inventors: Noriaki Arakawa, Hisashi Hirano, Hiroji Uemura, Yusuke Ito, Shohei Myoba, Norihisa Ohtake
  • Patent number: 11193936
    Abstract: The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: December 7, 2021
    Assignees: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, TOSOH CORPORATION
    Inventors: Noriaki Arakawa, Hisashi Hirano, Etsuko Miyagi, Norihisa Ohtake
  • Publication number: 20210190786
    Abstract: The present invention aims to provide a method for simply and highly accurately detecting castration-resistant prostate cancer (CRPC), and a reagent that can be used for this method. By measuring the level of GDF15 propeptide present in a sample as a novel detection marker for CRPC, acquisition of castration resistance in a prostate cancer patient during or after endocrine therapy is detected. An antibody that specifically recognizes GDF15 propeptide is included in the CRPC detection reagent.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 24, 2021
    Applicants: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, TOSOH CORPORATION
    Inventors: Noriaki ARAKAWA, Hisashi HIRANO, Hiroji UEMURA, Yusuke ITO, Shohei MYOBA, Norihisa OHTAKE
  • Publication number: 20210063400
    Abstract: An object of the present invention is to provide a method for detecting renal cancer, and a reagent that can be used for the method. Provided is a method for detecting renal cancer, which includes measuring the amount of TFPI2 in a sample derived from a patient. An antibody that specifically recognizes NT-TFPI2 and intact TFPI2 is included in a detection reagent for renal cancer.
    Type: Application
    Filed: December 26, 2018
    Publication date: March 4, 2021
    Applicants: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, TOSOH CORPORATIO
    Inventors: Noriaki ARAKAWA, Hisashi HIRANO, Noboru NAKAIGAWA, Masahiro YAO, Norihisa OHTAKE
  • Publication number: 20190170754
    Abstract: The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 6, 2019
    Applicants: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, TOSOH CORPORATION
    Inventors: Noriaki Arakawa, Hisashi Hirano, Etsuko Miyagi, Norihisa Ohtake
  • Publication number: 20170322228
    Abstract: The present invention provides methods in the context of Kawasaki disease including measuring the level of at least one of lipopolysaccharide binding protein, leucine-rich alpha-2-glycoprotein, angiotensinogen and retinol binding protein 4 in a sample derived from a subject.
    Type: Application
    Filed: July 26, 2017
    Publication date: November 9, 2017
    Applicant: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
    Inventors: Yayoi HORIUCHI, Masaaki Mori, Hisashi Hirano, Shumpei Yokota, Yoko Saito, Mao Aketagawa
  • Publication number: 20170322218
    Abstract: The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.
    Type: Application
    Filed: November 26, 2015
    Publication date: November 9, 2017
    Applicants: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, TOSOH CORPORATION
    Inventors: Noriaki ARAKAWA, Hisashi HIRANO, Etsuko MIYAGI, Norihisa OHTAKE
  • Publication number: 20060121473
    Abstract: Means for effecting rapid mass spectrometry of a multiplicity of samples; and a method of rapidly analyzing biosubstances such as nucleic acids and proteins. The above means is a solid support provided with a carbon layer onto which substances separated by gel electrophoresis are transferred. The above method is one for mass spectrometry of multiple substances which comprises separating substances of a sample by gel electrophoresis, transferring separated substances of the gel onto the above solid support so as to immobilize the same and subjecting the immobilized substances to desorption/ionization.
    Type: Application
    Filed: August 18, 2003
    Publication date: June 8, 2006
    Applicant: Toyo Kohan Co. Ltd.
    Inventors: Michifumi Tanga, Shuuichi Kamei, Hiroshi Okamura, Kaoru Yamakawa, Hirofumi Yamano, Mityuyoshi Ohba, Hisashi Hirano
  • Patent number: 6608830
    Abstract: A router controls transmission of packets over a plurality of networks. The router has a function of carrying out address translation of addresses added to the packets between private addresses and global addresses. A plurality of interfaces are each connected to a corresponding one of the plurality of networks. A first storage device stores data for the address translation, the data being set by a user. A second storage device stores information for applying the data stored in the first storage device to each of the plurality of interfaces, the information being set by the user. A control device prepares translation management information for each of the plurality of interfaces, based on the data stored in the first storage device and the information stored in the second storage device. A translation device is arranged in each of the plurality of interfaces, for carrying out the address translation of one of the addresses added to each packet of the packets, based on the translation management information.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: August 19, 2003
    Assignee: Yamaha Corporation
    Inventors: Hisashi Hirano, Ryota Hirose, Tsuneyuki Koikeda
  • Patent number: 5883869
    Abstract: An optical disc reading device successively reads out data from an optical disc where the data are recorded on a packet-by-packet basis in such a manner that a link block is formed as a written-data gap between every adjoining packets. The data read out from the optical disc are decoded and subjected to an error detecting and correcting operation block by block. The blocks decoded and subjected to the error detecting and correcting operation are then sequentially stored into a data buffer. When a non-correctable error is found in a specific one of the blocks stored in the data buffer, the data reading section is controlled to continue the successive data readout from the optical disc if the specific block having the non-correctable error is a link block. But, if the specific block is not a link block, it is invalidated and the data reading section is controlled to stop the successive data readout from the optical disc.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: March 16, 1999
    Assignee: Yamaha Corporation
    Inventors: Kazushi Tamai, Hisashi Hirano