Abstract: A ball joint includes a first lubricant interposed between a ball part of a ball stud and a bearing sheet. The ball joint includes a second lubricant having a higher friction coefficient than the first lubricant and enclosed inside a dust cover.

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.

Abstract: A ball joint (10) capable of stabilizing sliding torque while suppressing cost increase is provided. The ball joint (10) includes a first lubricant (G1) interposed between a ball part (40) of a ball stud (14) and a bearing sheet (13). The ball joint (10) includes a second lubricant (G2) having a higher friction coefficient than the first lubricant (G1) and enclosed inside a dust cover (15).

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.

Abstract: One aspect of the present invention resides in a hot melt adhesive including a thermoplastic polymer and a tackifier, wherein the tackifier includes an acid-modified tackifier that is modified by at least one of maleic acid and maleic anhydride, and by at least one selected from the group consisting of acrylic acid, methacrylic acid, an acrylic acid ester, and a methacrylic acid ester.

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.

Abstract: One aspect of the present invention resides in a hot melt adhesive including a thermoplastic polymer and a tackifier, wherein the tackifier includes an acid-modified tackifier that is modified by at least one of maleic acid and maleic anhydride, and by at least one selected from the group consisting of acrylic acid, methacrylic acid, an acrylic acid ester, and a methacrylic acid ester.

Abstract: A ball joint includes a ball seat for slidably holding a ball part of a ball stud. In the ball seat, a stud-side holder is housed in a housing of a socket while the stud-side holder is tilted and deformed to the ball part side by a tapered part. A first groove is formed in the stud-side holder of a holder of the ball seat. The first groove has an only shape with the curvature of the inner surface of the cross-section being a finite value, in other words, has a shape in which a shape with the curvature of the inner surface being an infinite value is not included. The first groove has a shape in which the first derivation value of the distance between the central axis of the tubular holder and the inner surface of the first groove consecutively changes.

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.

Abstract: There is provided a switching element including two electrodes and an organic bistable material sandwiched between the electrodes, which is expected to be applied to an organic memory element or the like. A switching element which includes: two electrodes; and an organic thin film containing a metal fine particle and interposed between the electrodes, and which exhibits such a current bistability that the switching element has two stable resistance values in response to a voltage applied, the switching element characterized in that the metal fine particle is dispersed in the organic thin film with a metal fine particle-dispersing agent containing a polymer having a dithiocarbamate group and having a weight average molecular weight of 500 to 5,000,000.

Abstract: There is provided a switching element including two electrodes and an organic bistable material sandwiched between the electrodes, which is expected to be applied to an organic memory element or the like. A switching element which includes: two electrodes; and an organic thin film containing a metal fine particle and interposed between the electrodes, and which exhibits such a current bistability that the switching element has two stable resistance values in response to a voltage applied, the switching element characterized in that the metal fine particle is dispersed in the organic thin film with a metal fine particle-dispersing agent containing a polymer having a dithiocarbamate group and having a weight average molecular weight of 500 to 5,000,000.

Abstract: A drum base according to he invention, on which a drum of a magnetic tape recorder is mounted, comprises a substantially annular frame having a fixing surface to which the drum is fixed; at least one through hole extending through the fixing surface for allowing a screw which is to be threadably attached to a threaded hole formed in the drum to pass therethrough; and a pair of mounting surfaces provided on the fixing surface on which the drum is mounted, the mounting surfaces being located adjacent to the at least one through hole so as to have a symmetrical relationship in a circumferential direction of the annular frame with respect to the at least one through hole and within a range of a diameter dimension of the at least one through hole in a radial direction of the annular frame.

Abstract: A device or arrangement of parts for electrically loading a movable member so as to bias same in one direction. In this device, an elastic member is secured to a pivot provided on a base member, with its two arms being deflected and then held by first and second locking members, after which a movable member is forced down against the elastic member from above, so that a guide portion of the movable member may push one arm of the elastic member so as to keep the arm apart from the locking member which locks the arm, and then a locking portion continuous with the guide portion, of the movable member locks the arm. As a result, the movable member is elastically loaded so as to bias in one direction, while the movement of the movable member is limited by means of a control member provided on the base member.