Patents by Inventor Hisashi Takahashi

Hisashi Takahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200249223
    Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.
    Type: Application
    Filed: April 23, 2020
    Publication date: August 6, 2020
    Inventors: Ryosuke TAKAHASHI, Katsuhiro KANDA, Yusuke SHIMIZU, Hisashi ICHIKAWA
  • Publication number: 20200219251
    Abstract: An image is generated where an edge of a structure in a subject is sharpened with reducing streak artifacts, within a short amount of time. X-rays at multiple angles are applied to the subject placed in imaging space, and a distribution of X-rays strength passing through the subject is detected to obtain raw data associated with multiple views. After smoothing the raw data associated with multiple views, image reconstruction is performed to generate a smoothed image of a predetermined region to be imaged in the imaging space. In the smoothed image, more intense sharpening process is applied to pixels in a region of a central part of the subject, than the pixels in a region of a peripheral part of the subject.
    Type: Application
    Filed: April 9, 2018
    Publication date: July 9, 2020
    Applicant: Hitachi, Ltd.
    Inventors: Hisashi TAKAHASHI, Taiga GOTOU, Koichi HIROKAWA
  • Publication number: 20200202499
    Abstract: A medical image processing device and a corresponding method are provided that can extract and enhance a signal in a medical image. A medical image processing device that applies image processing to a medical image, the device including an acquiring unit that acquires an original image, a first extraction unit that extracts a local bias component image, a creating unit that decomposes a difference image between the original image and the local bias component image into at least two frequency bands and creates a low-frequency component image formed of a component in the lowest frequency band, a second extraction unit that extracts a local bias component low-frequency image that is a local bias component of the low-frequency component image, and a computing unit that multiplies the local bias component low-frequency image by a gain, adds to the local bias component image, and computes a contrast enhanced image.
    Type: Application
    Filed: August 22, 2018
    Publication date: June 25, 2020
    Applicant: Hitachi, Ltd.
    Inventors: Hisashi Takahashi, Taiga Gotou, Koichi Hirokawa
  • Patent number: 10684276
    Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: June 16, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Ryosuke Takahashi, Katsuhiro Kanda, Yusuke Shimizu, Hisashi Ichikawa
  • Patent number: 10675714
    Abstract: Provided is a grain-oriented electrical steel sheet including a steel sheet having a steel sheet surface in which a groove, which extends in a direction intersecting a rolling direction and of which a groove depth direction matches a sheet thickness direction, is formed. An average depth D of the groove is greater than 10 ?m and equal to or less than 40 ?m in a case where the groove is seen on a groove-width-direction cross-section that is perpendicular to a groove extension direction, when a center of the groove in the groove width direction is defined as a groove width center, a deepest portion of the groove deviates from the groove width center toward one side in the groove width direction, and a cross-sectional shape of the groove is asymmetric with respect to the groove width center as a reference in the groove width direction.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: June 9, 2020
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Tatsuhiko Sakai, Hideyuki Hamamura, Hisashi Mogi, Fumiaki Takahashi
  • Publication number: 20200166858
    Abstract: An imprint apparatus comprises: a dispensing unit that dispenses a liquid to a substrate; a first measurement unit that measures a time from when a signal for causing the liquid to be dispensed is outputted to the dispensing unit until when the dispensed liquid passes through a predetermined position; a second measurement unit that measures a position of the liquid on the substrate that is dispensed by the dispensing unit; and a control unit that controls the measurement by the first measurement unit and the second measurement unit, wherein the control unit performs measurement by the second measurement unit based on a measurement result by the first measurement unit.
    Type: Application
    Filed: January 21, 2020
    Publication date: May 28, 2020
    Inventors: Hisashi Namba, Yuichi Takahashi
  • Patent number: 10662491
    Abstract: A grain-oriented electrical steel sheet comprising a steel sheet having a surface on which grooves, in which an extending direction crosses a rolling direction and a depth direction is parallel to a sheet thickness direction, are formed, and wherein a molten solidified substance ranging in parallel to the groove exists on both sides of the groove on the surface of the steel sheet, and a height becoming a maximum frequency in a height distribution of height data in which the surface of the steel sheet in a specific area including the groove is measured at regular intervals is set as a virtual plane, and a value of V2/V1 is more than 0.10 and less than 0.80, wherein V1 is a space volume of recess parts recessed from the virtual plane and V2 is a volume of projection parts projected from the virtual plane.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 26, 2020
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Takahito Mizumura, Fumiaki Takahashi, Masato Mizokami, Hisashi Mogi, Hideyuki Hamamura, Hirofumi Imai, Shinya Hayashi, Kenichi Murakami
  • Patent number: 10655029
    Abstract: An inkjet ink including: a stilbene-based compound represented by General Formula (1) below; where in the General Formula (1), R1 and R3 each independently represent, for example, an alkyl group including 1 to 20 carbon atoms, an alkenyl group including 1 to 20 carbon atoms, a phenyl group, or a naphthyl group.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 19, 2020
    Assignees: Ricoh Company, Ltd., Tokyo University of Science Foundation
    Inventors: Takuya Fujita, Yoshimasa Miyazawa, Hisashi Habashi, Tatsuya Tomura, Tomohiro Inoue, Yukishige Kondo, Yutaka Takahashi
  • Publication number: 20200151920
    Abstract: The present invention provides an image reconstruction apparatus and an image reconstruction method, both of which achieve reduction in a granular noise and a streak-like artifact both contained in a reconstruction image, and a clear structure boundary as well The image reconstruction apparatus configured to generate a reconstruction image includes a noise reduction section that generates a streak reduction image as an image obtained by reducing a streak-like artifact in the reconstruction image, a noise reduction ratio acquisition section that acquires a first noise reduction ratio as a noise reduction ratio to be used for reducing a granular noise while retaining a structure boundary in the reconstruction image, and a second noise reduction ratio as a noise reduction ratio to be used for generating the streak reduction image, and an image addition section that adds an addition image to be generated based on the first noise reduction ratio and the second noise reduction ratio to the streak reduction image.
    Type: Application
    Filed: October 29, 2019
    Publication date: May 14, 2020
    Applicant: Hitachi, Ltd.
    Inventors: Hisashi TAKAHASHI, Taiga GOTOU
  • Patent number: 10647075
    Abstract: A friction transmission belt has a rubber layer forming a pulley contacting portion. The rubber layer is made of a rubber composition containing a crosslinked rubber component and crosslinked polyolefin particles. Examples of the crosslinked polyolefin particles can contain ultrahigh molecular weight polyolefin particles having an average molecular weight of 500,000 or more.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: May 12, 2020
    Assignee: Bando Chemical Industries, Ltd.
    Inventors: Takayuki Okubo, Hisashi Matsuda, Hideaki Kawahara, Shinji Takahashi
  • Patent number: 10647593
    Abstract: The object of the invention is to provide an adsorbent that can adsorb ammonia with no large volume change between absorption and desorption, that has a high ammonia and/or ammonium ion adsorption capacity, and that can have an additional function by gaining proper control of composition, etc. The invention makes it possible to provide an adsorbent that absorbs ammonia and/or ammonium ions through the use of a metal cyanocomplex as an ammonia adsorbent, experiences no or little volume change, exhibits high enough capacity for adsorbing ammonia and/or ammonium ions, and has a function of decomposing ammonia as well as a function of varying optical responses before and after adsorption, etc.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: May 12, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Akira Takahashi, Tohru Kawamoto, Parajuli Durga, Hisashi Tanaka, Yutaka Sugiyama, Yukiya Hakuta
  • Publication number: 20200109139
    Abstract: The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
    Type: Application
    Filed: May 20, 2019
    Publication date: April 9, 2020
    Applicant: Japan Tobacco Inc.
    Inventors: Hisashi KAWASAKI, Hiroyuki ABE, Kazuhide HAYAKAWA, Tetsuya IIDA, Shinichi KIKUCHI, Takayuki YAMAGUCHI, Toyomichi NANAYAMA, Hironori KURACHI, Masahiro TAMARU, Yoshikazu HORI, Mitsuru TAKAHASHI, Takayuki YOSHIDA, Toshiyuki SAKAI
  • Patent number: 10578985
    Abstract: An imprint apparatus comprises: a dispensing unit that dispenses a liquid to a substrate; a first measurement unit that measures a time from when a signal for causing the liquid to be dispensed is outputted to the dispensing unit until when the dispensed liquid passes through a predetermined position; a second measurement unit that measures a position of the liquid on the substrate that is dispensed by the dispensing unit; and a control unit that controls the measurement by the first measurement unit and the second measurement unit, wherein the control unit performs measurement by the second measurement unit based on a measurement result by the first measurement unit.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 3, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Hisashi Namba, Yuichi Takahashi
  • Publication number: 20200062892
    Abstract: A method produces polybutylene terephthalate resin particles, which includes (a) a step of heating a polybutylene terephthalate resin in an organic solvent to obtain a solution of a polybutylene terephthalate resin (dissolution step), and (b) a step of flash-cooling the solution to precipitate polybutylene terephthalate resin particles (precipitation step). The method produces PBT resin particles by a simple operation that can be performed industrially.
    Type: Application
    Filed: November 13, 2017
    Publication date: February 27, 2020
    Inventors: Chizuru Asahara, Koya Ito, Toshiya Takahashi, Kei Makita, Hisashi Miyama
  • Publication number: 20200028280
    Abstract: There is provided with a cylindrical member that can be easily increased in size. The cylindrical member comprises a first cylindrical member that is constituted by a cylindrical fiber reinforced plastic member that has a first metal film on a surface thereof and a second cylindrical member that is constituted by a cylindrical fiber reinforced plastic member that has a second metal film on a surface thereof. The first metal film and the second metal film are joined to each other. The first metal film and the second metal film may be welded to each other. A joining member may pass through a first metal film and a second metal film.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 23, 2020
    Inventors: Hisashi SAKAMAKI, Tomoaki YOSHIBA, Junichi TAKAHASHI, Junichi ONOSAKA
  • Patent number: 10532784
    Abstract: Provided are a vehicle body assembling method and a vehicle body assembling apparatus which allow a simple configuration in the vicinity of the connecting portion between an upper jig and a lower jig and allow an increase in the efficiency of assembling work (welding work). A vehicle body assembling apparatus is equipped with a jig for supporting vehicle body components in a preassembled position, the jig comprising an upper jig and a lower jig which are connected to each other in at least two places. Each of the connection places is provided with a connecting means for fixing a three-dimensional coordinate position while allowing uniaxial turning. The vehicle body assembling apparatus is also equipped with a conveying means for conveying the upper jig which supports the vehicle body components, and reduces the load applied to the lower jig from the upper jig when connecting the upper jig to the lower jig.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: January 14, 2020
    Assignee: HONDA MOTOR CO., LTD.
    Inventors: Hisashi Ishitsuka, Hiroyuki Takahashi
  • Patent number: 10522596
    Abstract: In one embodiment, a semiconductor storage device includes a first interconnect extending in a first direction, a plurality of second interconnects extending in a second direction different from the first direction, and a plurality of first insulators provided alternately with the second interconnects. The device further includes a resistance change film provided between the first interconnect and at least one of the second interconnects and including a first metal layer or a first semiconductor layer that includes a first face provided on a first interconnect side and a second face provided on a second interconnect side, at least any of the first face and the second face having a curved plane shape.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: December 31, 2019
    Assignee: TOSHIBA MEMORY CORPORATION
    Inventors: Keiichi Sawa, Kazuhisa Matsuda, Atsushi Takahashi, Takaumi Morita, Masayuki Tanaka, Shinji Mori, Kazuhiro Matsuo, Yuta Saito, Kenichiro Toratani, Hisashi Okuchi
  • Patent number: 10483125
    Abstract: A semiconductor device includes a first interlayer film formed on an upper surface of a substrate, a first metal wiring line, a second interlayer film, a second metal wiring line, a first via electrically connecting the first metal wiring line and the second metal wiring line, a landing pad embedded in an upper portion of the first interlayer film and penetrating the second interlayer film, and a second via penetrating the substrate and the first interlayer film from a back side of the substrate and connected to the landing pad. The lower surface position of the landing pad is different from that of the first metal wiring line.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: November 19, 2019
    Assignee: TOWERJAZZ PANASONIC SEMICONDUCTOR CO., LTD.
    Inventors: Yuka Inoue, Mitsunori Fukura, Nobuyoshi Takahashi, Masahiro Oda, Hisashi Yano, Yutaka Ito, Yasunori Morinaga
  • Publication number: 20190333789
    Abstract: Provided is an assembling apparatus for a semiconductor manufacturing apparatus. The assembling apparatus includes: a body; lift attached to the body and configured to move a reaction tube having an opening at a lower end portion thereof vertically, thereby allowing a gas supply pipe to be installed inside the reaction tube through the opening while the reaction tube is held by the lift; gas supply source configured to supply a gas into the reaction tube through the gas supply pipe while the reaction tube is held by the lift; and an exhaust mechanism including a pump configured to exhaust an inside of the reaction tube through the opening, thereby performing a leakage test of the reaction tube while the reaction tube is held by the lift.
    Type: Application
    Filed: April 25, 2019
    Publication date: October 31, 2019
    Inventors: Hisashi Inoue, Masahiro Kobayashi, Michihiro Takahashi, Tamotsu Hatakeyama, Harunari Hasegawa, Hiroshi Kikuchi, Yoshihisa Kumagai
  • Patent number: 10434606
    Abstract: Provided is a grain-oriented electrical steel sheet including a steel sheet having a steel sheet surface in which a groove, which extends in a direction intersecting a rolling direction and of which a groove depth direction matches a sheet thickness direction, is formed. When an average value of a groove depth in a sheet thickness direction at a central portion of the groove in a longitudinal groove direction is set as an average groove depth D, a straight line, which connects a first point at which a groove depth in the sheet thickness direction becomes 0.05√óD and a second point at which the groove depth becomes 0.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: October 8, 2019
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Hideyuki Hamamura, Tatsuhiko Sakai, Fumiaki Takahashi, Hisashi Mogi, Shunsuke Okumura, Hirofumi Imai