Patents by Inventor Hisashi Takasu

Hisashi Takasu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino-terminal modified parathyroid hormone (PTH) analogs
    Patent number: 6537965
    Abstract: Disclosed are novel parathyroid hormone (PTH) peptide derivatives. In particular, the invention relates to PTH derivatives having amino acid substitutions that confer PTH-1/PTH-2 receptor agonist or antagonist properties to the derivatives. Also disclosed are methods of preparing these novel derivatives, and methods of using these derivatives to treat mammalian conditions.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: March 25, 2003
    Assignee: The General Hospital Corporation
    Inventors: F. Richard Bringhurst, Hisashi Takasu, Thomas J. Gardella
  • Modified human parathyroid hormone
    Patent number: 6417333
    Abstract: The present invention is related to novel synthetic and/or recombinant biologically active peptide derivatives of parathyroid hormone (PTH). In particular, the invention relates to PTH derivatives of 28 amino acids or less, with one or more amino acid substitutions, methods of their preparation and use.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: July 9, 2002
    Assignee: The General Hospital Corporation
    Inventors: F. Richard Bringhurst, Hisashi Takasu, Thomas J. Gardella, John T. Potts, Jr.
  • Screening assays for G protein coupled receptor agonists and antagonists
    Patent number: 6183974
    Abstract: Parathyroid hormone (PTH) and its closely related peptide, PTHrP, share the same receptor, PTHR. LLC-PK1 cells are porcine renal epithelial cells which do not normally express PTHR. The present invention provides stably transfected LLC-PK1 cells which express human PTHR. Also provided are methods for determining whether a compound of interest is an agonist or antagonist of a Gs or Gq protein coupled receptor.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: February 6, 2001
    Assignee: The General Hospital Corporation
    Inventors: F. Richard Bringhurst, Hisashi Takasu