Patents by Inventor Hisatoshi Kobayashi

Hisatoshi Kobayashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9327050
    Abstract: A hemostatic material as a high-performance medical material is described, which is capable of stopping bleeding in short time and is easy to handle and produce. The hemostatic material contains a nano-fiber that contains: a polymer, and a polypeptide having a peptide fragment represented by formula (1): -(Pro-Y-Gly)n-??(1) wherein Y represents hydroxyproline or proline, and n represents an integer ranging from 5 to 9000.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: May 3, 2016
    Assignee: JNC CORPORATION
    Inventors: Hisatoshi Kobayashi, Dohiko Terada, Masami Todokoro, Akiko Shimatani, Yukinori Kataoka
  • Patent number: 9200393
    Abstract: A polymer electrolyte fiber having a high molecular weight is produced with ease by an electrospinning method. In an electrospinning method which comprises applying a voltage to a solution of a polymer electrolyte to allow a jet of the solution to spurt, forming a polymer fiber, the voltage applied to the solution of the polymer electrolyte is a voltage having the opposite polarity to the charge of molecular chains of the polymer electrolyte in the solution, and the voltage is applied to increase the viscosity of the solution to be higher than that of the solution before applying the voltage, allowing the solution to spurt.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: December 1, 2015
    Assignee: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Hisatoshi Kobayashi, Dohiko Terada
  • Patent number: 8887621
    Abstract: A reciprocating compressor including an oscillation-type piston mechanism is provided with a piston ring which is mounted in a piston ring groove to seal a space between a piston and a cylinder. A ring groove other than the piston ring groove is provided at an outer periphery of the piston on a side away from the piston ring groove and closer to a crank shaft. A guide ring, which is inhibited from radial movement and shaped like a skirt opened toward the crank shaft, is mounted in the ring groove. Thus, the oscillation-type reciprocating compressor is adapted to maintain long-term durability even under high-pressure compression condition and to prevent heat propagation to a large end portion.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: November 18, 2014
    Assignee: Hitachi Industrial Equipment Systems Co., Ltd.
    Inventors: Akito Ohata, Hisatoshi Kobayashi
  • Publication number: 20130253099
    Abstract: With respect to synthetic collagen that has so far been difficult to be nano-fiberized, a method for producing uniform and long fibrous nano-fibers containing a synthetic collagen is described. The nano-fibers contain a polypeptide having a peptide fragment represented by Formula (1): -(Pro-Y-Gly)n??(1), wherein Y represents hydroxyproline or proline, and n is an integar ranging from 5 to 9000. The producing method includes a step of preparing a spinning solution containing the polypeptide and a polymer, and a step of spinning with an electrospinning method using the spinning solution.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Applicant: JNC CORPORATION
    Inventors: HISATOSHI KOBAYASHI, DOHIKO TERADA, MASAMI TODOKORO, AKIKO SHIMATANI, YUKINORI KATAOKA
  • Publication number: 20130251780
    Abstract: A hemostatic material as a high-performance medical material is described, which is capable of stopping bleeding in short time and is easy to handle and produce. The hemostatic material contains a nano-fiber that contains: a polymer, and a polypeptide having a peptide fragment represented by formula (1): -(Pro-Y-Gly)n- ??(1) wherein Y represents hydroxyproline or proline, and n represents an integer ranging from 5 to 9000.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Applicant: JNC CORPORATION
    Inventors: HISATOSHI KOBAYASHI, DOHIKO TERADA, MASAMI TODOKORO, AKIKO SHIMATANI, YUKINORI KATAOKA
  • Patent number: 8486139
    Abstract: It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: July 16, 2013
    Assignees: National University Corporation Tokyo Medical and Dental University, National Cerebral and Cardiovascular Center
    Inventors: Akio Kishida, Tsuyoshi Kimura, Hisatoshi Kobayashi, Toshiya Fujisato
  • Publication number: 20130109264
    Abstract: A polymer electrolyte fiber having a high molecular weight is produced with ease by an electrospinning method. In an electrospinning method which comprises applying a voltage to a solution of a polymer electrolyte to allow a jet of the solution to spurt, forming a polymer fiber, the voltage applied to the solution of the polymer electrolyte is a voltage having the opposite polarity to the charge of molecular chains of the polymer electrolyte in the solution, and the voltage is applied to increase the viscosity of the solution to be higher than that of the solution before applying the voltage, allowing the solution to spurt.
    Type: Application
    Filed: May 10, 2011
    Publication date: May 2, 2013
    Inventors: Hisatoshi Kobayashi, Dohiko Terada
  • Patent number: 8430650
    Abstract: A swing-type reciprocative compressor is capable of maintaining long durability and preventing propagation of heat to the large end portion of a piston, even under high-compression. In the reciprocative compressor having a swing-type piston mechanism, a piston ring is attached to a piston ring groove to seal between a piston and a cylinder. A ring groove is provided separately from the piston ring groove on the outer circumferential side of the piston and on the crankshaft side of the piston ring groove. A guide ring restricted from moving in a radial direction and shaped like a skirt opening toward the crankshaft side is provided in the ring groove.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: April 30, 2013
    Assignee: Hitachi Industrial Equipment Systems Co., Ltd.
    Inventors: Akito Ohata, Hisatoshi Kobayashi
  • Publication number: 20110256001
    Abstract: A reciprocating compressor provided with a piston, which is compact and having high sealing performance is provided. A reciprocating compressor includes: a low-pressure compressor unit having a low-pressure piston and a low-pressure cylinder for compressing air with the low-pressure piston reciprocating while oscillating within the low-pressure cylinder; a high-pressure compressor unit having a high-pressure piston and a high-pressure cylinder for further compressing the air compressed in the low-pressure compressor unit with the high-pressure piston reciprocating while oscillating within the high-pressure cylinder; and a motor for driving the low-pressure compressor unit and the high-pressure compressor unit. A maximum tilt angle during oscillation of the low-pressure piston is made larger than a maximum tilt angle during oscillation of the high-pressure piston.
    Type: Application
    Filed: February 8, 2011
    Publication date: October 20, 2011
    Applicant: Hitachi Industrial Equipment Systems Co., Ltd.
    Inventors: Hisatoshi KOBAYASHI, Akito Ohata, Susumu Sakamoto, Koichi Tashiro
  • Publication number: 20110247486
    Abstract: A reciprocating compressor including an oscillation-type piston mechanism is provided with a piston ring which is mounted in a piston ring groove to seal space between a piston and a cylinder. A ring groove other than the piston ring groove is provided at an outer periphery of the piston on a side away from the piston ring groove and closer to a crank shaft. A guide ring, which is inhibited from radial movement and shaped like a skirt opened toward the crank shaft, is mounted in the ring groove. Thus, the oscillation-type reciprocating compressor is adapted to maintain long-term durability even under high-pressure compression condition and to prevent heat propagation to a large end portion.
    Type: Application
    Filed: March 3, 2011
    Publication date: October 13, 2011
    Applicant: Hitachi Industrial Equipment Systems Co., Ltd.
    Inventors: Akito OHATA, Hisatoshi KOBAYASHI
  • Publication number: 20110223390
    Abstract: Disclosed is a polymer brush composite including a substrate, a solid layer disposed on the substrate and containing at least one of a metal or a metal oxide, and a plurality of polymer chains penetrating the solid layer in such a manner that one end of each of the polymer chains is disposed on the upper side of the substrate and the other end of each the polymer chains is exposed at a surface of the solid layer on an opposite side of the solid layer to the substrate. The polymer brush composite exhibits good adhesion between an organic polymer compound and an inorganic material and has the surface the organic polymer compound and the inorganic material uniformly coexist.
    Type: Application
    Filed: September 25, 2009
    Publication date: September 15, 2011
    Inventors: Takao Hanawa, Yusuke Tsutsumi, Kwangwoo Nam, Akio Kishida, Hisatoshi Kobayashi, Chiaki Yoshikawa
  • Publication number: 20100303645
    Abstract: This invention provides a swing-type reciprocative compressor capable of maintaining long durability and preventing propagation of heat to the large end portion of a piston, even under high-compression. In the reciprocative compressor having a swing-type piston mechanism, a piston ring is attached to a piston ring groove to seal between a piston and a cylinder. A ring groove is provided separately from the piston ring groove on the outer circumferential side of the piston and on the crankshaft side of the piston ring groove. A guide ring restricted from moving in a radial direction and shaped like a skirt opening toward the crankshaft side is provided in the ring groove.
    Type: Application
    Filed: January 6, 2010
    Publication date: December 2, 2010
    Applicant: Hitachi Industrial Equipment Systems Co., Ltd.
    Inventors: Akito OHATA, Hisatoshi Kobayashi
  • Patent number: 7741454
    Abstract: The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: June 22, 2010
    Assignees: National Institute for Materials Science, Furuuchi Chemical Corporation
    Inventors: Tetsushi Taguchi, Hisatoshi Kobayashi, Junzo Tanaka, Hirofumi Saito
  • Publication number: 20100145444
    Abstract: It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.
    Type: Application
    Filed: March 7, 2008
    Publication date: June 10, 2010
    Applicant: JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL CARD
    Inventors: Akio Kishida, Tsuyoshi Kimura, Hisatoshi Kobayashi, Toshiya Fujisato
  • Publication number: 20070254013
    Abstract: [Object] A medical material that improves therapeutic effects in epithelial cells such as keratoconjunctival epithelial cells with the use of an amnion, and a process for producing the same are provided. [Solving Means] A medical material includes an amnion, which is a placental tissue, a polymer film bonded to one surface of the amnion and crosslinked, and cells adhered to the other surface of the amnion. A process for producing the medical material includes the steps of preparing an amnion from which the spongy layer is removed, bonding a biocompatible polymer film to one surface of the amnion followed by crosslinking, adhering epithelial stem cells to the other surface of the amnion, and proliferating epithelial cells from the epithelial stem cells on the surface of the amnion.
    Type: Application
    Filed: February 1, 2005
    Publication date: November 1, 2007
    Applicant: NAT'L INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Tetsushi Taguchi, Hisatoshi Kobayashi, Junzo Tanaka, Kazuo Tsubota, Naoshi Shinozaki, Shigeto Shimmura, Hideyuki Miyashita
  • Patent number: 7153938
    Abstract: A method for producing a cross-linked apatite/collagen porous body comprising the steps of gelling and then freeze-drying a dispersion containing an apatite/collagen composite and collagen to form a porous body, and further cross-linking collagen in the porous body, and a cross-linked apatite/collagen porous body produced by this method.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: December 26, 2006
    Assignees: National Institute for Materials Science, PENTAX Corporation
    Inventors: Masanori Kikuchi, Junzo Tanaka, Hisatoshi Kobayashi, Daisuke Shoji
  • Publication number: 20060239958
    Abstract: Disclosed is a two-component, bio-degradable/absorbable adhesive medical material, which has a bonding component comprising a biodegradable polymer, and a hardening component comprising a low-molecular-weight derivative prepared by modifying a carboxyl group in a di- or tri-carboxylic acid of the citric acid cycle, with an electron-attracting group (one or a combination of two or more selected from the group consisting of a succinimidyl group, a sulfosuccinimidyl group, a maleimidyl group, a phthalimidyl group, an imidazolyl group, a nitrophenyl group and a tresyl group, and derivatives thereof).
    Type: Application
    Filed: February 5, 2004
    Publication date: October 26, 2006
    Inventors: Tetsushi Taguchi, Hisatoshi Kobayashi, Junzo Tanaka, Hirofumi Saito
  • Publication number: 20060128948
    Abstract: The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
    Type: Application
    Filed: September 11, 2003
    Publication date: June 15, 2006
    Inventors: Tetsushi Taguchi, Hisatoshi Kobayashi, Junzo Tanaka, Hirofumi Saito
  • Publication number: 20050271695
    Abstract: A method for producing a cross-linked apatite/collagen porous body comprising the steps of gelling and then freeze-drying a dispersion containing an apatite/collagen composite and collagen to form a porous body, and further cross-linking collagen in the porous body, and a cross-linked apatite/collagen porous body produced by this method.
    Type: Application
    Filed: May 6, 2005
    Publication date: December 8, 2005
    Applicants: National Institute for Materials Science, PENTAX Corporation
    Inventors: Masanori Kikuchi, Junzo Tanaka, Hisatoshi Kobayashi, Daisuke Shoji
  • Patent number: 4887687
    Abstract: A motorcycle frame is cast in two parts which are bolted together along the longitudinal centerline of the motorcycle. The frame has a transverse section in the form of an inverted "U", the space defined by the "U" being arranged to receive a motorcycle engine. An upper wall provides a separating partition between a fuel tank and the engine for defining a longitudinal space of reduced transverse sectional area towards the rear of the frame.
    Type: Grant
    Filed: June 17, 1988
    Date of Patent: December 19, 1989
    Assignee: Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Susumu Asai, Haruhide Sugimoto, Masaru Fujisaki, Tadatoshi Shigetomi, Hisatoshi Kobayashi