Abstract: A surgical device with ultrasound guidance and related techniques are disclosed. The disclosed surgical device includes an ultrasound probe and one or more guide portions configured to host a given surgical instrument. A given guide portion may be configured to permit linear movement of a surgical instrument hosted thereby, as well as angular movement of that instrument with respect to the ultrasound probe. In this manner, the disclosed surgical device may be configured to provide improved visualization of the surgical instrument(s), as well as a target tissue mass, by the ultrasound probe. This may realize improvements in control during the surgical process and in the efficiency of tissue removal as compared to existing approaches. The disclosed surgical device may be configured for use in a manner reducing the opportunity for ultrasound interference which otherwise might result in utilizing an ultrasound probe and an ultrasonic surgical instrument simultaneously.