Patents by Inventor Hisoshi Nakamura

Hisoshi Nakamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists
    Patent number: 7354925
    Abstract: This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a hydrogen atom, or the like; R4 represents a hydrogen atom or the like; represents one of the following or the like; R5 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: April 8, 2008
    Assignee: Pfizer Inc.
    Inventors: Yoshinobu Hashizume, Masako Hirota, Sachiko Mihara, Hisoshi Nakamura, Hiroki Koike, Yukari Matsumoto
  • Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonists
    Publication number: 20070197500
    Abstract: This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents a hydrogen atom, or the like; R4 represents a hydrogen atom or the like; (formula II) represents one of the following or the like; R5 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
    Type: Application
    Filed: March 19, 2005
    Publication date: August 23, 2007
    Inventors: Yoshinobu Hashizume, Masako Hirota, Sachiko Mihara, Hisoshi Nakamura, Hiroki Koike, Yukari Matsumoto