Patents by Inventor Hitesh Handa

Hitesh Handa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250135170
    Abstract: Described herein are compositions and articles for delivering nitric oxide to a subject. The compositions described herein can eradicate pathogens in a subject. In one aspect, the compositions described herein can be applied as a coating to a medical device. In other aspects, the compositions described herein can be used to produce a medical device that can release nitric oxide. The compositions and articles described herein can be used to treat or prevent bacterial infections and biofilm formation in a subject.
    Type: Application
    Filed: October 23, 2024
    Publication date: May 1, 2025
    Inventors: Manjyot Kaur Chug, Elizabeth Brisbois, Hitesh Handa, Natalie Crutchfield
  • Publication number: 20250090573
    Abstract: Described herein are compositions for delivering fluoride ions and nitric oxide to a subject. The compositions described herein include a poloxamer, an alginate, a nitric oxide releasing compound, fluoride ions, and calcium ions. In one aspect, the compositions are hydrogels. The compositions described herein can eradicate oral pathogens and prevent demineralization of teeth in a subject.
    Type: Application
    Filed: January 17, 2023
    Publication date: March 20, 2025
    Inventors: Hitesh Handa, Lori Marie Estes Bright, Elizabeth J. Brisbois, Mark Garren
  • Publication number: 20240366545
    Abstract: Described herein are antibacterial nanoparticles composed of a porphyrin and a nitric oxide donor. In one aspect, the antibacterial nanoparticles are produced by the method comprising (a) admixing a porphyrin with glutathione or a pharmaceutically acceptable salt or ester thereof to produce a first compound and (b) reacting the first compound with a nitric oxide compound, wherein the nitric oxide compound forms a covalent bond with glutathione or the pharmaceutically acceptable salt or ester. The antibacterial nanoparticles are dynamic in their ability to specifically target pathogenic infections while remaining nontoxic towards mammalian cells and can also be used as medical device coatings to prevent infections as well as in treatment and management of diseases like cancer and autoimmune skin disorders.
    Type: Application
    Filed: August 9, 2022
    Publication date: November 7, 2024
    Inventors: Hitesh Handa, Anil Kumar, Elizabeth J. Brisbois
  • Publication number: 20240299629
    Abstract: Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.
    Type: Application
    Filed: May 20, 2024
    Publication date: September 12, 2024
    Inventors: Hitesh Handa, Marcus Goudie
  • Publication number: 20240228801
    Abstract: Described herein are coating compositions having unique mechanical and physical properties. The coating compositions are composed of zinc oxide nanoparticles, copper nanoparticles, a perfluorolkylsiloxane, and an organic solvent. The coating compositions can be applied to any article or any surface of an article where it is desirable to reduce surface wettability or prevent the growth of bacteria.
    Type: Application
    Filed: February 9, 2022
    Publication date: July 11, 2024
    Inventors: Hitesh HANDA, Ekrem OZKAN
  • Patent number: 12016974
    Abstract: Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: June 25, 2024
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Hitesh Handa, Marcus Goudie
  • Publication number: 20240158476
    Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.
    Type: Application
    Filed: January 5, 2024
    Publication date: May 16, 2024
    Inventors: Hitesh Handa, Marcus Goudie, Jitendra Pant, Bryan Grommersch, Sean Hopkins
  • Publication number: 20240139385
    Abstract: Described herein are methods for controlling the release of nitric oxide from a nitric oxide releasing material. The method involves exposing the nitric oxide releasing material to light having a discrete wavelength, wherein the nitric oxide releasing material comprises a (i) a polysiloxane network and (ii) a plurality of nitric oxide-donating moieties covalently bonded to the polysiloxane network. The tunability of nitric oxide release from the nitric oxide releasing materials described herein provides unique therapeutic profiles that correspond to endogenous thresholds of nitric oxide for desired physiological response. The methods described herein can prevent bacterial growth as well as the formation of biofilms and fibrinogen on articles such as, for example, medical devices.
    Type: Application
    Filed: October 12, 2023
    Publication date: May 2, 2024
    Inventors: Hitesh HANDA, Mark GARREN, Elizabeth J. BRISBOIS, Megan Elizabeth BROOKS, Morgan Musialowski ASHCRAFT
  • Publication number: 20240132732
    Abstract: Described herein are coating compositions having unique mechanical and physical properties. The coating compositions are composed of zinc oxide nanoparticles, copper nanoparticles, a perfluorolkylsiloxane, and an organic solvent. The coating compositions can be applied to any article or any surface of an article where it is desirable to reduce surface wettability or prevent the growth of bacteria.
    Type: Application
    Filed: February 9, 2022
    Publication date: April 25, 2024
    Inventors: Hitesh HANDA, Ekrem OZKAN
  • Publication number: 20240131231
    Abstract: Described herein are compositions comprising a nitric oxide releasing material comprising a (i) a polysiloxane network and (ii) a plurality of nitric oxide-donating moieties covalently bonded to the polysiloxane network; and (b) a silicone oil. Also described herein are articles composed of the compositions described herein and methods for using the same. The compositions described herein provide highly sustained, long-term nitric oxide release that have numerous biological activities such as, for example, preventing localized platelet activation, fibrinogen adhesion, and biofilm formation for a prolonged period of time.
    Type: Application
    Filed: February 1, 2022
    Publication date: April 25, 2024
    Inventors: Hitesh HANDA, Sean P. HOPKINS
  • Publication number: 20240050631
    Abstract: Described herein are substrates, devices, methods for treating and preventing bacterial and fungal infections, such as infections associated with medical devices, and the like. Materials, substrates and devices of the present disclosure include materials, such as medical grade polymers, having a coating/layer of polyene antimycotic molecules coupled to a surface of the polymer substrate. In certain aspects, substrates and devices of the present disclosure also include a nitric oxide (NO) releasing material also embedded in/coated on the material. Methods of the present disclosure includes methods of making the compositions and/or devices of the present disclosure including materials functionalized with polyene antimycotic molecules and NO releasing materials. Embodiments also include methods of using the materials, substrates, and devices of the present disclosure to treat/prevent fungal and/or bacterial infections in a subject, particularly infections associated with the use of a medical device.
    Type: Application
    Filed: July 14, 2021
    Publication date: February 15, 2024
    Inventors: Hitesh HANDA, Ryan P. DEVINE, Megan Elizabeth BROOKS
  • Patent number: 11897775
    Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: February 13, 2024
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Hitesh Handa, Marcus Goudie, Jitendra Pant, Bryan Grommersch, Sean Hopkins
  • Publication number: 20230256136
    Abstract: Described herein are biocompatible materials that include a nitric oxide (NO) donor embedded in silk fibroin nanoparticles. In one aspect, the nitric oxide donor is present in the hydrophobic core of the silk fibroin nanoparticles such that the nitric oxide donor is encapsulated. The biocompatible materials described herein serve as a biocompatible and inexpensive nitric oxide delivery platform that provide sustained release of nitric oxide. The biocompatible materials are non-toxic and can be used in biomedical applications such as wound healing, where a combination of therapeutic and antibacterial properties of silk and nitric oxide are desired. Additionally, described herein are methods of making the biocompatible materials.
    Type: Application
    Filed: July 28, 2021
    Publication date: August 17, 2023
    Inventors: Hitesh HANDA, Sama GHALEI
  • Publication number: 20230053808
    Abstract: Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.
    Type: Application
    Filed: May 13, 2022
    Publication date: February 23, 2023
    Inventors: Jason J. LOCKLIN, Qiaohong LIU, Priyadarshini SINGHA, Hitesh HANDA, Jitendra PANT, Marcus J. GOUDIE, Sean P. HOPKINS
  • Patent number: 11370934
    Abstract: Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: June 28, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Jason J. Locklin, Qiaohong Liu, Priyadarshini Singha, Hitesh Handa, Jitendra Pant, Marcus J. Goudie, Sean P. Hopkins
  • Publication number: 20220143262
    Abstract: Wound dressings and methods for treating a wound are provided. The wound dressing can have an environment-facing side that includes a biocompatible material having a polymer crosslinked with an antimicrobial effective amount of a NO-donor and a woundfacing side including a biocompatible resinous matrix and an antifibrinolytic agent. The wound dressing can promote fibrin formation and rapid platelet aggregation, and has antimicrobial properties. The dressing can be applied directly to the wound.
    Type: Application
    Filed: February 25, 2020
    Publication date: May 12, 2022
    Inventors: Jitendra PANT, Dieu Thao NGUYEN, Hitesh HANDA
  • Patent number: 11220516
    Abstract: The present disclosure provides for modified antibiotic compounds, methods of making modified antibiotic compounds, methods of use, products including modified antibiotic compounds, and the like. The modified antibiotic compound comprises a nitric oxide release agent covalently attached to an antibiotic molecule, such as S-nitroso-N-acetylpenicillamine covalently attached to ampicillin.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: January 11, 2022
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Hitesh Handa, Sean P. Hopkins, Priyadarshini Singha, Christina Danielle Workman
  • Publication number: 20210380420
    Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.
    Type: Application
    Filed: August 11, 2021
    Publication date: December 9, 2021
    Inventors: Hitesh Handa, Marcus Goudie, Jitendra Pant, Bryan Grommersch, Sean Hopkins
  • Publication number: 20210361834
    Abstract: Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.
    Type: Application
    Filed: August 9, 2021
    Publication date: November 25, 2021
    Inventors: Hitesh Handa, Marcus Goudie
  • Patent number: D1066723
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: March 11, 2025
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Elizabeth Brisbois, Manjyot Kaur Chug, Hitesh Handa, Megan E. Douglass