Abstract: An implantable medical device and a method of deduplicating data collected by the implantable medical device are provided. The method includes storing data, captured by the implantable medical device, in a non-volatile memory device of the implantable medical device, assigning a unique number, generated from a random number generator or counter, to each data block of the data, and deduplicating the data by deleting at least one of two or more data blocks that are associated with the same unique number.

Abstract: The disclosure provides systems and methods for automatically titrating an electrical pulse amplitude for a patient-implanted VNS stimulator. One or more external sensors (e.g., EEG, EKG, EMG, auditory sensors, inertial motion sensors, etc.) can be applied to the patient to generate data relevant to an acceptable amplitude of the electrical pulse for a given cathode in a multi-cathode cuff. In one embodiment, the device may include a controller on the implanted VNS stimulator that receives data, e.g., using a wireless connection, from the external sensors and titrates upward the amplitude until an acceptable amplitude is determine that provides efficacy with minimal, if any, side effects.

Abstract: The disclosure provides systems and methods for system for vagus nerve stimulation (VNS), using a VNS stimulator implanted in a human subject and configured to transmit electrical stimulation pulses to a vagus nerve of the human subject; and at least one sensor configured to detect a predefined pattern of tactile input, a bodily gesture, and/or a voice command from the human subject, wherein the VNS stimulator includes a controller configured to modulate at least one stimulation parameter of the electrical stimulation pulses based at least in part on the tactile input, bodily gesture, and/or voice command from the human subject.