Abstract: A one-piece removable therapeutic dental orthotic to be worn on a wearer's lower dentition. The orthotic has occlusally bulging fulcrum regions positioned over a wearer's left and right first molar and second bicuspid, so that the orthotic initially contacts only a pair of fulcrum teeth of the wearer's upper dentition during the wearer's jaw closure movement, without any of the wearer's teeth touching each other. The initial contact locations serve as a fulcrum, and clearance is provided between the wearer's upper dentition and clearance regions of the orthotic on mesial and distal sides of the fulcrum regions, allowing the wearer's jaw to pivot about the fulcrum while the upper dentition remains in contact with the fulcrum regions and touches no other part of the orthotic.

Abstract: A device may receive frames of a video capturing an analog meter with a dial and a needle, may process the frames to identify a center, a radius, and a perimeter of the dial, and may determine calibrated values for the dial. The device may apply a model to one of the frames to create a base mask, may apply thresholding for a dynamic HSV bounding value, to the base mask and the frames, to create masked frames, and may identify contours for the masked frames. The device may identify a quantity of points for each of the contours, may estimate angles of the needle of the analog meter based on the quantity of points, and may average the estimated angles to determine an averaged needle angle. The device may determine a needle direction based on the averaged needle angle and may calculate a meter reading.

Abstract: A device may receive frames of a video capturing an analog meter with a dial and a needle, may process the frames to identify a center, a radius, and a perimeter of the dial, and may determine calibrated values for the dial. The device may apply a model to one of the frames to create a base mask, may apply thresholding for a dynamic HSV bounding value, to the base mask and the frames, to create masked frames, and may identify contours for the masked frames. The device may identify a quantity of points for each of the contours, may estimate angles of the needle of the analog meter based on the quantity of points, and may average the estimated angles to determine an averaged needle angle. The device may determine a needle direction based on the averaged needle angle and may calculate a meter reading.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: Modular machine tools, modular machine-tool beds, and systems for assembling the same are disclosed. Some machine tools and beds may be configured selectively between a cantilever configuration and a gantry configuration. Some modular beds may be assembled selectively to have a desired longitudinal length. The modular nature of the machine tools and modular beds allows users to configure a machine tool in multiple configurations depending on a particular work piece needing to be worked.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: Machine tools and methods for machining turbine rotor assemblies are disclosed. Some machine tools include a drill arm that pushes off of a turbine stage that is adjacent to a turbine stage to be machined. Some machine tools include a clamping arm that secures the machine tool to a turbine stage to be machined and an adjacent turbine stage. Some methods include pushing-off of a turbine stage that is adjacent to a turbine stage to be machined. Some methods include securing a machine tool to a turbine stage that is adjacent to a turbine stage to be machined. Some methods include monitoring at least one of a current delivered to a first motor and a voltage applied to the first motor and controlling a second motor in response to the monitoring. Some methods include sequentially machining a turbine stage with cutting tools having increasing lengths and/or diameters.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: Machine tools and methods for machining turbine rotor assemblies are disclosed. Some machine tools include a drill arm that pushes off of a turbine stage that is adjacent to a turbine stage to be machined. Some machine tools include a clamping arm that secures the machine tool to a turbine stage to be machined and an adjacent turbine stage. Some methods include pushing-off of a turbine stage that is adjacent to a turbine stage to be machined. Some methods include securing a machine tool to a turbine stage that is adjacent to a turbine stage to be machined. Some methods include monitoring at least one of a current delivered to a first motor and a voltage applied to the first motor and controlling a second motor in response to the monitoring. Some methods include sequentially machining a turbine stage with cutting tools having increasing lengths and/or diameters.

Abstract: Modular machine tools, modular machine-tool beds, and systems for assembling the same are disclosed. Some machine tools and beds may be configured selectively between a cantilever configuration and a gantry configuration. Some modular beds may be assembled selectively to have a desired longitudinal length. The modular nature of the machine tools and modular beds allows users to configure a machine tool in multiple configurations depending on a particular work piece needing to be worked.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: The present invention relates to intermediates of rosuvastatin and processes for the production thereof.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein substituted 3-carboxamido isoxazoles compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.

Abstract: The invention provides methods and compositions for treating conditions mediated by Bcr-Abl. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.

Abstract: The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.

Abstract: The present invention relates to intermediates of rosuvastatin and processes for the production thereof.