Abstract: Provided is an automatic analyzer capable of appropriately controlling most of the temperature of an incubator even when local temperature fluctuation occurs. An automatic analyzer for analyzing a specimen includes an incubator for holding a plurality of vessels that store a mixed liquid of the specimen and a reagent, a heat source for heating or cooling the incubator, a plurality of temperature sensors provided at different positions of the incubator and measuring the temperature, and a control unit for controlling an output of the heat source based on a difference between a target temperature and the highest temperature or the lowest temperature among the measured temperatures of the temperature sensors.

Abstract: The present inventors used microarrays to identify a novel gene from cDNA clones showing significantly different gene expression in normal tissues compared to psoriasis lesion tissues. This gene was named secretory Ly-6/uPAR-related protein-2 (SLURP-2). Quantitative real-time RT-PCR analysis using total RNA extract was used to compare SLURP-2 gene expression between psoriatic lesional skin, non-lesional skin, and normal skin, to indicate that the SLURP-2 gene is significantly upregulated in psoriasis lesions. Thus, SLURP-2 gene can be used as a diagnostic marker for inflammatory skin diseases such as psoriasis.