Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.

Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.

Abstract: A ruthenium-based sputtering target having a cast structure, in which a sputter surface of the sputtering target includes at least two or more types of regions, and crystal surfaces in the regions are different from each other, each of the crystal surfaces being specified by a main peak of X-ray diffraction. An object of the present disclosure is to provide a Ru-based sputtering target having no void, having high purity and a low degree of structural anisotropy, and capable of forming a Ru-based film having low particle properties, high film thickness uniformity, and high surface uniformity, and a method for manufacturing the same. According to the present disclosure, there is provided a ruthenium-based sputtering target having a cast structure, in which a sputter surface of the sputtering target includes at least two or more types of regions, and crystal surfaces in the regions are different from each other, each of the crystal surfaces being specified by a main peak of X-ray diffraction.

Abstract: This is to provide a safety hook 1 having a function of preventing and/or delaying removal of an exhibit 7 by unauthorized persons and a function of preventing unexpected display falling, and has good operability. The safety hook 1 has a grip body 17 capable to be fixed to a hanging wire 3, and a hook 23 for hanging an article, and connected to the body (17). Further, it has a hook cover 21 displaceable between a closed position for closing an opening portion 23z of the hook 23 and an open position for opening the opening portion 23z, and a cover cap 19 which hinders displacement of the hook cover 21 from the closed position to the open position.

Abstract: This is to provide a safety hook 1 having a function of preventing and/or delaying removal of an exhibit 7 by unauthorized persons and a function of preventing unexpected display falling, and has good operability. The safety hook 1 has a grip body 17 capable to be fixed to a hanging wire 3, and a hook 23 for hanging an article, and connected to the body (17). Further, it has a hook cover 21 displaceable between a closed position for closing an opening portion 23z of the hook 23 and an open position for opening the opening portion 23z, and a cover cap 19 which hinders displacement of the hook cover 21 from the closed position to the open position.

Abstract: A remote copy system includes a plurality of storage systems. Each first storage system assigns a sequential number to write data received from the host and sends the write data with the sequential number to the second storage system. One of the first storage systems defers the processing of the write request received from the host and instructs each of the first storage systems to create a marker that includes a sequential number that is a marker number. The second storage systems receive the marker from the first storage system and store the marker number included in the marker.