Abstract: A lubricating oil for use in hot-rolling oil for aluminum sheet, comprises: (a) a mineral oil having a kinematic viscosity of 80 mm2/second or less at 40° C.; (b) 1 to 14 mass % of a fatty acid having 10 to 22 carbon atoms; (c) 5 to 15 mass % of an oil and fat and/or a synthetic ester; (d) 5 to 10 mass % of a phosphorus-containing extreme-pressure agent; (e) 0.1 to 1 mass % of a polyoxyethylene alkyl amine; and 0.1 to 10 mass % of an organic acid salt of a copolymer composed of a (meth)acrylic acid salt, (meth)acrylamide, and at least one amine monomer, and the mass ratio of the component (c) to the component (d) (component (c)/component (d)) is 1/0.6 to 1/1. The lubricating oil for use in hot-rolling oil for aluminum sheet of the invention provides a high level of rolling lubricity, iron corrosion protection in a hot-rolling step and a rolled aluminum sheet with high sheet surface quality can be obtained.

Abstract: A method for treating retinal diseases includes administering an effective amount of midkine to patients suffering from retinal diseases. The method of the invention is effective in ameliorating optical disorders of retinas and is quite safe.