Abstract: A compound represented by the following general formula (1), or a salt or hydrate thereof: wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl or ethyl group, R4 represents a C1-C6 alkyl group, R5 represents a hydrogen atom, provided that a compound wherein R1 is a C1-C6 alkyl group unsubstituted or substituted with a halogen atom and R2 is a hydrogen atom is excluded.

Abstract: Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydrogen, hydroxyl, alkyl, or the like; L is a single bond, a double bond, alkylene, or the like; M is a single bond, alkylene, or the like; T is a single bond, alkylene, or the like; W is carboxyl, —CON(RW1)RW2, or the like; represents a single or double bond; X is oxygen, alkenylene, or the like; Y is an aromatic hydrocarbon group which may contain a heteroatom, or the like; and Z is an aromatic hydrocarbon group which may contain a heteroatom.

Abstract: The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g.

Abstract: The present invention provides a novel pyrimidine compound having an excellent adenosine receptor (A1, A2A, A2B receptor) antagonistic action. More specifically, it provides a compound represented by the following formula, a salt thereof or a solvate of them.

Abstract: The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.

Abstract: For forming an annular magnetostrictive coat on an outer peripheral surface of a rotational shaft associated with a magnetostrictive torque sensor, a magnetostrictive-coat forming method comprises a step of fitting a cylindrical masking jig over the outer peripheral surface of the rotational shaft and securing the masking jig to the outer peripheral surface, a step of placing the rotational shaft in a plating tank to thereby form the magnetostrictive coat by plating on the outer peripheral surface, and a step of detaching the masking jig from the rotational shaft.

Abstract: The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them.

Abstract: A class of substituted compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (II), wherein R1 is selected from hydrido, halo, alkoxy, aryl, alkylthio, alkylamino, aralkoxy, azido and alkenyloxy; wherein R2 is selected from hydrido, cyano, hydroxyalkyl, haloalkyl, aminoalkyl, alkylaminoalkyl, alkylcarbonyloxyalkyl, aminocarbonyl and alkylcarbonylaminoalkyl; and wherein R5 and R6 are one more radicals independently selected from halo, alkylsulfonyl, aminosulfonyl, alkoxy and alkylthio; provided one of R5 and R6 is substituted with alkysulfonyl, aminosulfonyl, or haloalkylsulfonyl; or a pharmaceutically-acceptable salt thereof.

Abstract: The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them.

Abstract: The present invention provides 2-aminopyridine compound having an excellent adenosine receptor (A1, A2a, A2b receptors) antagonism, which is represented by the following formula: 1

Abstract: The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.

Abstract: The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonistic action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof has an adenosine A2 receptor antagonistic action and is useful for prevention or therapy of diabetes mellitus and diabetic complications. In addition, adenosine A2 receptor antagonists having different structures from those of the compounds described above, for example KW6002, are also effective for prevention or therapy of diabetes mellitus and diabetic complications. In the formula, W is —CH2CH2—, —CH═CH— or —C≡C—; R1 is: (in the formula, X is hydrogen atom, hydroxyl group, a lower alkyl group, a lower alkoxy group, etc.

Abstract: There is disclosed a wafer-manufacturing method in which a single crystal ingot is first sliced into a plurality of wafers, and both surfaces of each wafer are subjected to grinding or lapping operation. Then, the front and back surfaces of the wafer are subjected to etching. Thereafter, the back surface of the wafer is subjected to chemical mechanical polishing to half-polish the same, following which the wafer is placed on a polishing machine, with the half-polished back surface of the wafer being adhered to a carrier plate; and the front surface of the wafer is mirror-polished. In the foregoing, a polysilicon film for extrinsic gettering may be formed on the back surface of the etched wafer prior to the half-polishing.

Abstract: A food vessel comprising a heating element for use in a household microwave oven is provided. The heating element is made of paper and a dielectric material such as aluminum foil. When bread dough or so forth is put into the vessel to be heated in the microwave oven, temperature of the heating element rapidly increases to a desired value and the bread dough rises while remaining in contact with the heating element. A uniformly browned loaf of bread of any desired configuration can thus be produced.

Abstract: The filter element of the present has a plurality of wavy portions which are so arranged that a plurality of wavy portions make a generally ring like structure. In order to reduce the pressure drop when the fluid flows through the filter element, the present filter element has a special shaped radial gaps. Namely, the width of a first radial gaps, which is formed within adjacent wavy portions and which connects with an inner space formed at the center of the generally ring like structure, increases from the outer end thereof to the inner end thereof. The width of a second radial gap, which is connected with outer atmosphere, decreases from the outer end thereof to the inner end thereof. Both axial ends of the wavy portions are covered with the adhesive sheet on which adhesive layer is cladded.

Abstract: A thermosetting synthetic resin composition consisting mainly of, for example, an epoxy resin is melted at a temperature of 70.degree. to 130.degree. C. After adding a filler to the resin composition, the resultant mixture is kneaded and rapidly cooled. The composition consists of a thixotropy agent, a leveling agent, etc., in addition to the epoxy resin and a curing agent for the epoxy resin. Aluminum as the filler is added in the amount of 30 wt % to 100 wt % of the mixture. The mixture of the composition with the filler is kneaded and rapidly cooled and is then pulverized to prepare a powder. The powder coating thus obtained is coated on a coil and is cured to provide a heat radiating insulator.

Abstract: An aluminium alloy cylinder includes a cylinder body and a cylinder bore therein. An iron layer is electrodeposited on the wall surface of the cylinder bore by means of a high cathode current density so that a multiplicity of randomly oriented channels are formed in the electrodeposited iron layer.