Patents by Inventor Hitoshi Ichikawa

Hitoshi Ichikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250006304
    Abstract: Disclosed is a method for controlling an information processing apparatus configured to analyze a sequence of nucleic acid obtained from a specimen of a subject, the method including: obtaining, on the basis of a plurality of first reads read by a sequencer, a result of mutation detection in an analysis target region in the sequence of the nucleic acid; generating, on the basis of second reads, out of the first reads, that correspond to at least one predetermined site selected from a base sequence in the analysis target region, information regarding a quality of a nucleic acid analysis with respect to the predetermined site; and outputting the information regarding the quality, irrespective of presence or absence of a mutation at the predetermined site.
    Type: Application
    Filed: June 28, 2024
    Publication date: January 2, 2025
    Applicants: National Cancer Center, SYSMEX CORPORATION
    Inventors: Takashi KOHNO, Kuniko SUNAMI, Hitoshi ICHIKAWA, Asuka SHIOTA, Kentaro FUJIWARA, Michiko YOSHIMOTO, Mio YUMURA, Takanori WASHIO
  • Publication number: 20200385779
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an OCLN gene and a part of an ARHGAP26 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding OCLN and an antisense primer designed from a section encoding ARHGAP26.
    Type: Application
    Filed: March 13, 2020
    Publication date: December 10, 2020
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa, Makoto Asaumi, Kazuhisa Tsunoyama
  • Publication number: 20200299782
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an RP2 gene and a part of an ARHGAP6 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding RP2 and an antisense primer designed from a section encoding ARHGAP6.
    Type: Application
    Filed: March 13, 2020
    Publication date: September 24, 2020
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa
  • Patent number: 10619216
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an RP2 gene and a part of an ARHGAP6 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding RP2 and an antisense primer designed from a section encoding ARHGAP6.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: April 14, 2020
    Assignees: Astellas Pharma Inc., National Cancer Center
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa
  • Patent number: 10619184
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an OCLN gene and a part of an ARHGAP26 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding OCLN and an antisense primer designed from a section encoding ARHGAP26.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: April 14, 2020
    Assignees: Astellas Pharma Inc., National Cancer Center
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa, Makoto Asaumi, Kazuhisa Tsunoyama
  • Publication number: 20180251850
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an RP2 gene and a part of an ARHGAP6 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding RP2 and an antisense primer designed from a section encoding ARHGAP6.
    Type: Application
    Filed: August 23, 2016
    Publication date: September 6, 2018
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa
  • Publication number: 20180237862
    Abstract: The object of the invention is to elucidate a new causative gene of cancer, polynucleotide, and thereby provide a method for detecting the polynucleotide or a polypeptide that is encoded by the polynucleotide, as well as a primer set or a detection kit for such detection. The detection method detects a fusion gene of a part of an OCLN gene and a part of an ARHGAP26 gene, or a fusion protein encoded by such gene. The primer set includes a sense primer designed from a section encoding OCLN and an antisense primer designed from a section encoding ARHGAP26.
    Type: Application
    Filed: August 23, 2016
    Publication date: August 23, 2018
    Inventors: Hiroki Sasaki, Hitoshi Ichikawa, Makoto Asaumi, Kazuhisa Tsunoyama
  • Publication number: 20160289663
    Abstract: To identify a mutation that can serve as an indicator for predicting the effectiveness of drug treatment in cancers such as leukemia; to provide a means for detecting said mutation; and to provide a means for identifying, based on said mutation, patients with cancer or subjects with a risk of cancer, in whom a drug targeting a gene having said mutation or a protein encoded by said gene shows a therapeutic effect. A method for detecting a gene fusion serving as a responsible mutation (driver mutation) for cancer, the method comprising the step of detecting an ATF7IP-PDGFRB fusion polynucleotide or a polypeptide encoded thereby, in an isolated sample from a subject.
    Type: Application
    Filed: November 17, 2014
    Publication date: October 6, 2016
    Inventors: Nobutaka Kiyokawa, Kenji Matsumoto, Kenichiro Kobayashi, Hitoshi Ichikawa
  • Patent number: 5873700
    Abstract: An earth and sand wear resisting hydraulic machine disposed in pressurized water and having movable guide vanes, has a wear resisting material against earth and sand applied by spraying or welding to the front end of a vane body of each guide vane, to the surface of a vane body portion located below the center of a water flowing portion of the vane body and to upper and lower end faces of the vane body. Consequently, the guide vanes and end faces are protected against wear caused by earth and sand.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: February 23, 1999
    Assignee: Hitachi, Ltd.
    Inventor: Hitoshi Ichikawa
  • Patent number: 5649354
    Abstract: A block of material used for making a movable core for a fuel injector is prepared from a bar or coil of material by clamp shearing using a working fluid containing an extreme-pressure additive (such as sulfur, chlorine or phosphorus). The additive reacts with the material to form a protective layer (of e.g. sulfide, chloride or phosphate) on the cut-off surface of the block. The block is cold forged so that its cut-off surface having the protective layer may form a wall defining a fuel passage. The layer prevents the material from being seized with any die or punch used for cold forging.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: July 22, 1997
    Assignee: Nippondenso Co., Ltd.
    Inventors: Hiroyuki Fujii, Hitoshi Ichikawa, Toshihiro Imai
  • Patent number: 5497364
    Abstract: An optical recording/reproducing apparatus including an optical recording medium having an alternating area in which information may be recorded instead of the normal recording area when the information fails to be recorded in the normal recording area, and a plurality of control regions in which position information of the recording area having failed to record information and position information of the alternating area in which the information failed to be recorded is recorded instead of the recording area. The apparatus records the information in a predetermined information recording area of the optical recording area, reproduces the predetermined information, collates the information intended to be recorded with the reproduced predetermined information, and judges that the predetermined information was not correctly recorded in the predetermined recording area.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: March 5, 1996
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Hitoshi Ichikawa, Osao Miyazawa, Masanobu Nakamura
  • Patent number: 5364229
    Abstract: A hydroelectric installation includes a hydraulic machine connected vertically below an electric machine by a shaft, in a concrete installation pit. A guide vane assembly of the hydraulic machine is operated by a motor-driven operating unit which projects below the hydraulic machine in a lower working space of the pit. The shaft has a thrust bearing which bears down against the upper cover of the hydraulic machine and thereby substantially cancels upward hydraulic force exerted on that upper cover. In the installation procedure, the outer casing, speed ring and upper cover of the hydraulic machine are installed first, so that the hydraulic machine can be assembled downwardly in the lower working space concurrently with upward assembly of the electric machine in an upper working space of the pit. This shortens installation time.
    Type: Grant
    Filed: March 18, 1993
    Date of Patent: November 15, 1994
    Assignee: Hitachi, Ltd.
    Inventors: Tetuo Fujihara, Takashi Ito, Fuminori Iwaki, Hitoshi Ichikawa
  • Patent number: 5351227
    Abstract: An optical recording/reproducing apparatus including an optical recording medium having an alternating area in which information may be recorded instead of the normal recording area when the information fails to be recorded in the normal recording area, and a plurality of control regions in which position information of the recording area having failed to record information and position information of the alternating area in which the information failed to be recorded is recorded instead of the recording area. The apparatus records the information in a predetermined information recording area of the optical recording area, reproduces the predetermined information, collates the information intended to be recorded with the reproduced predetermined information, and judges that the predetermined information was not correctly recorded in the predetermined recording area.
    Type: Grant
    Filed: February 27, 1991
    Date of Patent: September 27, 1994
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Hitoshi Ichikawa, Osao Miyazawa, Masanobu Nakamura
  • Patent number: 5132956
    Abstract: An optical recording/reproducing apparatus arranged to perform verification processing on whether or not information has been correctly recorded in a target sector of an optical recording medium by reproducing the information. If the target sector is determined to be defective, linkage information about the correspondence between the target sector and an alternative sector is stored/recorded and the verify processing is continued until a non-defective alternative sector is detected. Thus, only linkage information about the correspondence between the non-defective sector and the target sector is registered and linkage information about the corespondence between the defective alternative sector and the target sector is erased.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: July 21, 1992
    Assignee: Olympus Optical Co., Ltd.
    Inventor: Hitoshi Ichikawa
  • Patent number: 4837758
    Abstract: In the present invention, a discriminating means of recording media is formed in a cartridge containing a magneto-optical type recording media and in a cartridge containing other recording media, a sheltering height of a field applying means is changed according to the loading of each cartridge so that said field applying means is held close to the recording media in the case of the magneto-optical type cartridge while said means is sheltered high in the case of other type cartridge, and at the same time a discriminating means for recording media is provided to perform the signal processing corresponding to the recording media loaded.
    Type: Grant
    Filed: September 19, 1986
    Date of Patent: June 6, 1989
    Assignee: Olympus Optical Co., Ltd.
    Inventors: Kazuyasu Motoyama, Tsuneo Yanagida, Mitsugu Sakai, Hitoshi Ichikawa, Akihiko Yoshizawa
  • Patent number: 4771547
    Abstract: A correction apparatus for an azimuth calculation system which includes an azimuth sensor mounted on a moving body for producing two mutually perpendicular magnetic field components relative to the earth's magnetism acting thereon, and wherein the azimuth sensor is moved in a full circle so that an azimuth circle is formed by the two magnetic field components.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: September 20, 1988
    Assignee: Nippondenso Co., Ltd.
    Inventors: Kazushi Akutsu, Hitoshi Ichikawa
  • Patent number: 4739560
    Abstract: An azimuth calculation apparatus includes an azimuth sensor mounted on a moving body for detecting a direction of the moving body, the azimuth sensor having an excitation winding wound on an annular magnetic core and a pair of output windings wound on the core perpendicularly relative to one another to produce first and second output signals therefrom in response to energization of the excitation winding. The calculation apparatus is arranged to detect a temperature of the azimuth sensor and to determine a pair of correction values based on the detected temperature of the azimuth sensor so as to correct each value of the first and second output signals from the output windings to an optimal value for calculating the direction of the moving body in dependence upon the corrected output signals from the output windings.
    Type: Grant
    Filed: October 9, 1986
    Date of Patent: April 26, 1988
    Assignee: Nippondenso Co., Ltd.
    Inventors: Kazushi Akutsu, Hitoshi Ichikawa