Patents by Inventor Hitoshi Ikeya

Hitoshi Ikeya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyaluronic acid-methotrexate conjugate
    Patent number: 8088916
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: January 3, 2012
    Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi
  • Hyaluronic acid-methotrexate conjugate
    Patent number: 7807675
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: October 5, 2010
    Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Noriyuki Izutani, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi, Tatsuya Kato, Akie Honma
  • Hyaluronic Acid-Methotrexate Conjugate
    Publication number: 20090093414
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
    Type: Application
    Filed: April 1, 2005
    Publication date: April 9, 2009
    Applicant: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Noriyuki Izutani, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi, Tatsuya Kato, Akie Honma
  • Hyaluronic Acid-Methotrexate Conjugate
    Publication number: 20070197465
    Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
    Type: Application
    Filed: March 4, 2005
    Publication date: August 23, 2007
    Applicants: Denki Kagaku Kabushiki Kaisha, Chugai Seiyaku Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi
  • Hyaluronic acid and its salt for treating skin diseases
    Patent number: 5728391
    Abstract: An agent for treating a skin disease selected from the group consisting of a contact dermatitis treating agent, a xerosis senilis treating agent, an asteatosis treating agent, a housewives eczema treating agent, a keratosis treating agent, an eczema chronicum treating agent, a miliaria treating agent and a diaper rash treating agent, which contains hyaluronic acid and/or its salt having an average molecular weight of from 800,000 to 4,000,000, as an active ingredient.
    Type: Grant
    Filed: December 5, 1995
    Date of Patent: March 17, 1998
    Assignee: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hitoshi Ikeya, Hironoshin Kitagawa