Abstract: A laser processing head mounted on a robot arm moves from with a constant speed in a direction from a welding point to a next welding point, while a reflection mirror continuously turns in order to maintain laser beams focused on the welding point until the welding at the welding point is completed, and the reflection mirror quickly turns to shift the focus of the laser beams onto the next welding point when the welding at the welding point is completed.

Abstract: The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50 to approximately 250 ?m and an apparent specific gravity of approximately 0.5 to approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and a saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier to a high concentration in terms of solid concentration in a solvent and spray drying this liquid and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising the particles.

Abstract: In nonlinear optical crystal 183D, each step of wavelength conversion can be performed using another fundamental wave that is output from light output unit 1612, without using the fundamental wave whose output level has been attenuated after going through wavelength conversion for several steps (wavelength conversion in nonlinear optical crystals 183A to 183C). Therefore, the wavelength conversion efficiency improves and the peak power of optical amplifiers 1611 and 1612 can be suppressed, which allows the wavelength of lights that are output from optical amplifiers 1611 and 1612 to be further narrowed.

Abstract: The present invention makes it possible to provide drug-containing coated microparticles for quick-disintegrating oral tablets wherein microparticles containing a drug with an unpleasant taste are coated with a film composed of (1) a pH-independent water-insoluble polymer accounting for 60% or more but less than 80% of the film and (2) a pH-independent water-soluble substance accounting for more than 20% to 40% or less of the film, these microparticles being characterized in that the rate of dissolution of the drug from the drug-containing microparticles is 0% to 10% in one minute and 80% to 100% in 30 minutes, and the average particle diameter is 350 ?m or less, in order to realize sufficient control of oral drug dissolution and fast gastrointestinal drug dissolution.

Abstract: The present invention provides marked results in that it is possible to present by a simple method a dry powder inhalation for pulmonary delivery that is made from a biologically active substance in crystal form and a biocompatible, electrostatic aggregation-inhibiting substance and that has excellent safety, stability, and pulmonary delivery performance.

Abstract: The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50˜approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5˜approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide.

Abstract: The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50˜approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5˜approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide.

Abstract: A shock absorbing material comprising an Al—Mg—Si series aluminum alloy having high strength and showing excellent energy absorbing property when compressed in the axial direction of extrusion is obtained. The shock absorbing material of the invention has a hollow cross section, mainly comprises a fibrous structure and can be manufactured by press quenching just after extrusion followed by aging. In the press quenching, press quenching under air-cooling advantageous in view of the dimensional accuracy or the cost can be adopted. Further, the shock absorbing material of the invention has excellent cracking resistance to a compressive load in the lateral direction as well as in the axial direction. The shock absorbing material of the invention is suitable as side members or bumper stays in the frame structures of automobiles.

Abstract: An Al-Mg-Si based aluminum alloy extrusion having large strength, absorbable impact energy and resistance against compressing cracking, wherein the average size of Mg2Si precipitation in the [1 0 0] and [0 1 0] directions of the (1 0 0) plane inside grains is 20 nm or more, the distribution density of the Mg2Si precipitation in the [0 0 1] direction of the (1 0 0 ) plane is 100 or more per &mgr;m2, and the size of precipitations on grain boundaries is 1000 nm or less. Alternatively, in the Al-Mg-Si based aluminum alloy extrusion, a tensile strength obtained from a tensile test performed at a strain rate of 1000 per second is from 150 to 400 N/mm2 (both inclusive).

Abstract: A system for releasing a drug specifically in the colon of the gastrointestinal tract, which comprises a drug (b) coated with an organic acid-soluble polymer material (a), and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract; a colon-specific drug release oral preparation, which comprises a composition comprising a drug (b) coated with an organic acid-soluble polymer material (a) and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract, said composition being coated with an enteric coating polymer material (d). The invention provides a drug release system and a preparation which utilize enterobacteria, which do not form harmful substances due to the release-starting mechanism, show rapid degradation, and have higher colon specificity.

Abstract: A shock absorbing material comprising an Al—Mg—Si series aluminum alloy having high strength and showing excellent energy absorbing property when compressed in the axial direction of extrusion is obtained. The shock absorbing material of the invention has a hollow cross section, mainly comprises a fibrous structure and can be manufactured by press quenching just after extrusion followed by aging. In the press quenching, press quenching under air-cooling advantageous in view of the dimensional accuracy or the cost can be adopted. Further, the shock absorbing material of the invention has excellent cracking resistance to a compressive load in the lateral direction as well as in the axial direction. The shock absorbing material of the invention is suitable as side members or bumper stays in the frame structures of automobiles.

Abstract: A cooling system capable of adequately press-quenching an extruded product of heat-treatable aluminum alloy immediately after extrusion without causing deformation and warpage in its cross section.

Abstract: The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50˜approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5˜approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide.

Abstract: A system for releasing a drug specifically in the colon of the gastrointestinal tract, which comprises a drug (b) coated with an organic acid-soluble polymer material (a), and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract; a colon-specific drug release oral preparation, which comprises a composition comprising a drug (b) coated with an organic acid-soluble polymer material (a) and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract, said composition being coated with an enteric coating polymer material (d).

Abstract: A system for releasing a drug specifically in the colon of the gastrointestinal tract, which comprises a drug (b) coated with an organic acid-soluble polymer material (a), and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract; a colon-specific drug release oral preparation, which comprises a composition comprising a drug (b) coated with an organic acid-soluble polymer material (a) and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract, said composition being coated with an enteric coating polymer material (d). The invention provides a drug release system and a preparation which utilize enterobacteria, which do not form harmful substances due to the release-starting mechanism, show rapid degradation, and have higher colon specificity.

Abstract: An Al—Mg—Si based aluminum alloy extrusion having large strength, absorbable impact energy and resistance against compressing cracking, wherein the average size of Mg2Si precipitation in the [1 0 0] and [0 1 0] directions of the (1 0 0) plane inside grains is 20 nm or more, the distribution density of the Mg2Si precipitation in the [0 0 1] direction of the (1 0 0) plane is 100 or more per &mgr;m2, and the size of precipitations on grain boundaries is 1000 nm or less. Alternatively, in the Al—Mg—Si based aluminum alloy extrusion, a tensile strength obtained from a tensile test performed at a strain rate of 1000 per second is from 150 to 400 N/mm2 (both inclusive).

Abstract: A second harmonic generation (SHG) device is used for conversion of wavelength. The direction of polarization of light beams is suitably rotated by a direction-of-polarization rotating unit, for example by 45.degree., and thereafter these light beams are guided into the SHG device. This can minimize attenuation of intensity of light beam due to conversion of wavelength. Hence, using this direction-of-polarization rotating unit in the apparatus for measuring the medium, the intensity of light being incident upon the photodetector can be increased, whereby the refractive index of the medium can be measured more accurately than by the conventional apparatus.

Abstract: To obtain an accurate concentration of nonvolatile contents promptly and easily, an electrodeposition paint of which pH, temperature, and organic solvent concentration are in specified ranges is irradiated with ultrasonic waves, and its damping factor is measured, and on a basis of the result from the measurement, the concentration of nonvolatile contents in the electrodeposition paint is determined.