Patents by Inventor Hitoshi Komatsuzawa

Hitoshi Komatsuzawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bactericide having selectivity to cariogenic bacterium, and a method for sterilization of cariogenic bacterium
    Patent number: 8852584
    Abstract: The bacteriolytic effect of a bacterial cell wall lytic enzyme can be increased by the addition of a surfactant to the enzyme. As a result, the time required for lysis of cariogenic bacterium with the bacterial cell wall lytic enzyme can be shortened, and the practical utility of the bacterial cell wall lytic enzyme (such as automutanolysin) as a prophylactic or therapeutic agent for dental caries can be improved.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: October 7, 2014
    Assignee: Two Cells Co., Ltd.
    Inventors: Motoyuki Sugai, Hitoshi Komatsuzawa
  • Bactericide against and
    Patent number: 7776325
    Abstract: The present invention provides an enzyme with lytic activity against cariogenic bacteria and a means for treating and preventing tooth decay using the enzyme. The enzyme provided by the present invention is a lytic enzyme produced by Streptococcus mutans and has a substrate specificity for lysing selectively Streptococcus mutans and Streptococcus sobrinus. Therefore, application of the enzyme enables to remove selectively cariogenic bacteria or to decrease the number of cariogenic bacteria inside oral cavity, and may exert preventive effect against tooth caries.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: August 17, 2010
    Assignee: Two Cells Co., Ltd.
    Inventors: Motoyuki Sugai, Hitoshi Komatsuzawa
  • Bactericide having selectivity to cariogenic bacterium, and a method for sterilization of cariogenic bacterium
    Publication number: 20090274635
    Abstract: The bacteriolytic effect of a bacterial cell wall lytic enzyme can be increased by the addition of a surfactant to the enzyme. As a result, the time required for lysis of cariogenic bacterium with the bacterial cell wall lytic enzyme can be shortened, and the practical utility of the bacterial cell wall lytic enzyme (such as automutanolysin) as a prophylactic or therapeutic agent for dental caries can be improved.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 5, 2009
    Applicant: TWO CELLS CO., LTD
    Inventors: Motoyuki Sugai, Hitoshi Komatsuzawa
  • Bactericide Against Streptococcus Mutans and Streptococcus Sobrinus
    Publication number: 20080311056
    Abstract: The present invention provides an enzyme with lytic activity against cariogenic bacteria and a means for treating and preventing tooth decay using the enzyme. The enzyme provided by the present invention is a lytic enzyme produced by Streptococcus mutans and has a substrate specificity for lysing selectively Streptococcus mutans and Streptococcus sobrinus. Therefore, application of the enzyme enables to remove selectively cariogenic bacteria or to decrease the number of cariogenic bacteria inside oral cavity, and may exert preventive effect against tooth caries.
    Type: Application
    Filed: November 29, 2004
    Publication date: December 18, 2008
    Applicant: Two Cells Co., Ltd.
    Inventors: Motoyuki Sugai, Hitoshi Komatsuzawa