Abstract: A dermal filler composition including a coloring agent dispersed in a continuous phase composed of cross-linked hyaluronic acid gel particles, wherein the coloring agent is one or more of vitamin B2 and B12.

Abstract: A hyaluronic acid (HA) bead and a filler including the same, along with a process for preparing the HA beads. The process includes combining an HA compound with sodium hydroxide, forming an HA solution, and injecting the HA solution into an oil solution, forming an emulsion with HA beads. A cross-linking reagent is added and the mixture is stirred for 24 hours in room temperature, thereby forming cross-linked HA beads. The HA beads are cross-linked and adapted to dissolve in vivo upon contact with hyaluronidase.

Abstract: This disclosure provides a hyaluronic acid (HA) bead, a dermal filler having hyaluronic acid (HA) and a process for preparing the HA beads. The process includes combining an HA compound with sodium hydroxide, forming an HA solution, and injecting the HA solution into an oil solution, and forming an emulsion with HA beads. A cross-linking reagent is added and the mixture is stirred for 24 hours in room temperature, thereby forming cross-linked HA beads. The HA beads are cross-linked and adapted to dissolve in vivo upon contact with hyaluronidase.

Abstract: A biocompatible, degradable dermal filler system is composed of unmodified macroporous chitosan microbeads dispersed uniformly in a continuous phase composed of cross-linked hyaluronic acid gel particles and unmodified hyaluronic acid.

Abstract: A method is provided for probing the effective hydrodynamic flow of a liquid at various positions within a dissolution testing apparatus. The method includes embodiments of an appropriate electrode probe, and methods of generating a signature pattern from the sampled current that may be used to characterise the hydrodynamic flow of the liquid in the apparatus. The signature pattern may be used to validate and qualify the performance of the dissolution apparatus, diagnose problems with dissolution apparatus, predict the initial dissolution rate of a drug, or determine the local flow rate around specific parts of a drug.

Abstract: A method is provided for probing the effective hydrodynamic flow of a liquid at various positions within a dissolution testing apparatus. The method includes embodiments of an appropriate electrode probe, and methods of generating a signature pattern from the sampled current that may be used to characterise the hydrodynamic flow of the liquid in the apparatus. The signature pattern may be used to validate and qualify the performance of the dissolution apparatus, diagnose problems with dissolution apparatus, predict the initial dissolution rate of a drug, or determine the local flow rate around specific parts of a drug.