Abstract: The ? antigen-encoding gone and the ? antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of allergic diseases such as IgE production, histamine release and eosinophil infiltration, and therefore they are very effective for the prevention or treatment of atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis, and more broadly allergic diseases.

Abstract: The execution of a process is analyzed by a data processing method using a data analysis device for processing a job by combining the processes of transforming an input data and generating an output data. The execution history of the process is recorded, and each time the process is executed, it is determined whether the process execution is high in anomaly probability based on a determination indicator defined in advance. Upon determination that the process execution is high in anomaly probability, the process log information of the process including the determination indicator is recorded, and based on the process log information and the process execution history, the process high in anomaly probability is further analyzed, By determining whether the process to be analyzed is anomalous or not, the process history analysis information including the analysis result and the execution history of the process to be analyzed is generated.

Abstract: It is judged whether the reference data is the latest and if not the latest, the data is updated to the latest in a short time. A program in which data creation procedure is pre-defined creates requested secondary data according to primary data. The primary data, the secondary data, and data update information including the primary data update time and the secondary data update time are stored in a storage device. When the relationship between data update information on the primary data and the secondary data used for creating the requested secondary data when generation of the secondary data is requested and the data update information on the requested secondary data does not satisfy a predetermined condition, a program for creating the requested secondary data is executed. Furthermore, the primary data and the secondary data are outputted to the output unit while correlating them to each other.

Abstract: There is provided a spread illuminating apparatus including a light guide plate, and an LED structure which is disposed at a side surface of the light guide plate, includes: a substrate having electrode patterns formed thereon; an LED chip disposed on the electrode patterns; and a light-transmittable resin adapted to seal up the LED chip and exposed due to a lamp house not provided therearound, and which has a longitudinal dimension substantially equal to the longitudinal dimension of the side surface of the light guide plate. The electrode patterns are formed so as to cover substantially the entire area of a surface of the substrate. Accordingly, heat generated by the LED chip can be efficiently transmitted and released outside, and also light introduced in the light guide plate is suppressed from leaking out from the side surface of the light guide plate.

Abstract: A spread illuminating apparatus includes: at least one light source; a light conductive plate which has the at least one light source disposed at one end surface thereof, and which allows light emitted from the at least one light source and introduced therein to exit out therefrom through both major surfaces thereof toward first and second liquid crystal display elements disposed respectively over the both major surfaces of the light conductive plate, wherein the second liquid crystal display element has a smaller display screen size than the first liquid crystal display element; and a reflecting means which is disposed at the other major surface of the light conductive plate so as to cover at least areas not covered by the second liquid crystal display element, and which reflects light toward the first liquid crystal display element.

Abstract: A spread illuminating apparatus is provided which includes: a light conductive plate having a light entrance surface and a light exit surface; a plurality of LEDs disposed at the light entrance surface of the light conductive plate; a light reflecting sheet disposed at the light exit surface so as to cover a portion of the light conductive plat located close to the side surface and also the LEDs, and a plurality of light diffusing portions disposed at the light reflecting sheet so as to cover respective LEDs. Lights leaking from the LEDs are diffused by the light diffusing portions thus preventing the brightness variation at the areas closed to the LEDs, and the leakage lights are reflected by the light reflecting sheet into the light conductive plate so as to be efficiently utilized thus achieving an enhanced brightness across the light exit surface of the light conductive plate.

Abstract: The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocyte (KC), and their usages. The methods are preferably applicable for understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying, on skin of mice or the like, protein. A (SpA) derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to high level in serum, which elevation is generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.

Abstract: A gear pump having an inner rotor and an outer rotor is covered by a cylindrical outer casing and side casings. The cylindrical outer casing has two outer circumferential edges which are welded over the entire circumference thereof to the outer edges of the side casings, respectively. The outer casing has two angularly spaced recesses in its inner periphery for receiving slide seals therein. Welding is started at a welding start point which is 90 degrees spaced from the middle point between two recesses. During welding, welding energies are applied to the welding start point and the middle point between two recesses. Those energies tend to deform the casing into oval shapes that are 90 degrees out of phase from each other. Thus, these energies cancel each other, thereby preventing the casing from being deformed.

Abstract: There is provided a spread illuminating apparatus including a light guide plate, and an LED structure which is disposed at a side surface of the light guide plate, includes: a substrate having electrode patterns formed thereon; an LED chip disposed on the electrode patterns; and a light-transmittable resin adapted to seal up the LED chip and exposed due to a lamp house not provided therearound, and which has a longitudinal dimension substantially equal to the longitudinal dimension of the side surface of the light guide plate. The electrode patterns are formed so as to cover substantially the entire area of a surface of the substrate. Accordingly, heat generated by the LED chip can be efficiently transmitted and released outside, and also light introduced in the light guide plate is suppressed from leaking out from the side surface of the light guide plate.

Abstract: A spread illuminating apparatus for illuminating two objects includes: at least one light source; a light conductive plate having the at least one light source at an end surface thereof and defining first and second major surfaces from which light emitted from the at least one light source and introduced in the light conductive plate exits out respectively toward two objects to be illuminated; an optical sheet unit consisting of a diffuser sheet and condenser sheets, and disposed on at least the second major surface so as to cover an entire area thereof; and a reflecting means having a smaller surface area than the second major surface, and disposed directly on top of the optical sheet unit.

Abstract: Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings. The transgenic non-human mammals according to the present invention spontaneously develop atopic dermatitis under specific pathogen-free conditions, and therefore, are useful as disease model animals. Use of the transgenic non-human mammals according to the present invention makes it possible to develop drugs for preventing or treating atopic dermatitis by natural immunity and also to elucidate the onset mechanisms of atopic diseases.

Abstract: The ? antigen-encoding gene and the ? antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of allergic diseases such as IgE production, histamine release and eosinophil infiltration, and therefore they are very effective for the prevention or treatment of atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis, and more broadly allergic diseases.

Abstract: A transgenic rodent or its offspring which carries DNA having an exogenous caspase 1 gene integrated thereinto in such a manner as to express the gene specifically to the skin. The transgenic rodent of the present invention spontaneously develops atopic dermatitis in the absence of any specific pathogenic microorganism and is useful as a disease model animal. The transgenic rodent of the present invention is useful for developing preventive and/or therapeutic drugs for atopic dermatitis based on natural immunity and to clarify the onset mechanism of atopic diseases.

Abstract: In a spread illuminating apparatus comprising a spot-like light source, and a light conductive plate, the light conductive plate is shaped into a pentagon which has two sides thereof substantially parallel to each other. The pentagon includes, as a part thereof, a triangle having its base defined by an imaginary line connecting respective straightly opposing ends of the two parallel sides, and the spot-like light source is disposed at a side of the pentagon constituting one of two hypotenuses of the triangle.

Abstract: The curvature of a circular arc constituted by a side of a suction groove is made larger than that of a circular arc constituted by a side of a discharge groove. Thus, when the suction groove and the discharge groove are viewed in the axial direction of a drive shaft, the distance between the suction groove and the discharge groove in the radial direction of a rotary portion is short in a region intersecting with a line W perpendicular to a centerline, and increases in accordance with a decrease in distance from containment portions. It is therefore possible to ensure a sufficient distance between the discharge and suction grooves and enhance a total fluid pressure generated therebetween, and the contact surface pressure that is necessitated by a second side plate to obtain a press-back force when being in contact with an outer rotor and an inner rotor is reduced.

Abstract: In a spread illuminating apparatus comprising a spot-like light source, and a light conductive plate, the light conductive plate is shaped into a pentagon which has two sides thereof substantially parallel to each other, and which includes, as a part thereof, a triangle having its base defined by an imaginary line connecting respective straightly opposing ends of the two parallel sides, and the spot-like light source is disposed at a side of the pentagon constituting one of two hypotenuses of the triangle.

Abstract: A gear pump having an inner rotor and an outer rotor is covered by a cylindrical outer casing and side casings. The cylindrical outer casing has two outer circumferential edges which are welded over the entire circumference thereof to the outer edges of the side casings, respectively. The outer casing has two angularly spaced recesses in its inner periphery for receiving slide seals therein. Welding is started at a welding start point which is 90 degrees spaced from the middle point between two recesses. During welding, welding energies are applied to the welding start point and the middle point between two recesses. Those energies tend to deform the casing into oval shapes that are 90 degrees out of phase from each other. Thus, these energies cancel each other, thereby preventing the casing from being deformed.

Abstract: Transgenic non-human mammals comprising a DNA with an exogenous IL-18 gene incorporated in it such that the exogenous IL-18 gene is skin-specifically expressed, or their offsprings.

Abstract: A spread illuminating apparatus for illuminating two objects includes: at least one light source; a light conductive plate having the at least one light source at an end surface thereof and defining first and second major surfaces from which light emitted from the at least one light source and introduced in the light conductive plate exits out respectively toward two objects to be illuminated; an optical sheet unit consisting of a diffuser sheet and condenser sheets, and disposed on at least the second major surface so as to cover an entire area thereof; and a reflecting means having a smaller surface area than the second major surface, and disposed directly on top of the optical sheet unit.

Abstract: A spread illuminating apparatus includes: at least one light source; a light conductive plate which has the at least one light source disposed at one end surface thereof, and which allows light emitted from the at least one light source and introduced therein to exit out therefrom through both major surfaces thereof toward first and second liquid crystal display elements disposed respectively over the both major surfaces of the light conductive plate, wherein the second liquid crystal display element has a smaller display screen size than the first liquid crystal display element; and a reflecting means which is disposed at the other major surface of the light conductive plate so as to cover at least areas not covered by the second liquid crystal display element, and which reflects light toward the first liquid crystal display element.