Patents by Inventor Hitoshi Ohki
Hitoshi Ohki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10774087Abstract: Provided is a novel compound or a salt thereof inhibiting MTHFD2 and useful for treating a disease caused by overexpression of MTHFD2, a disease involved in overexpression of MTHFD2 and/or a disease associated with overexpression of MTHFD2. Solution Provided is a sulfonamide derivative having a coumarin skeleton represented by the following formula (I) and having various substituents: wherein R1, R2, R3, R4, R5, R6 and R7 are the same as defined in the specification, and a salt thereof.Type: GrantFiled: November 22, 2017Date of Patent: September 15, 2020Assignee: Daiichi Sankyo Company, LimitedInventors: Masahiro Ota, Hidekazu Inoue, Junya Kawai, Hitoshi Ohki, Tadashi Toki
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Publication number: 20190284198Abstract: Provided is a novel compound or a salt thereof inhibiting MTHFD2 and useful for treating a disease caused by overexpression of MTHFD2, a disease involved in overexpression of MTHFD2 and/or a disease associated with overexpression of MTHFD2. Solution Provided is a sulfonamide derivative having a coumarin skeleton represented by the following formula (I) and having various substituents: wherein R1, R2, R3, R4, R5, R6 and R7 are the same as defined in the specification, and a salt thereof.Type: ApplicationFiled: November 22, 2017Publication date: September 19, 2019Applicant: Daiichi Sankyo Company, LimitedInventors: Masahiro Ota, Hidekazu Inoue, Junya Kawai, Hitoshi Ohki, Tadashi Toki
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Patent number: 8933103Abstract: Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.Type: GrantFiled: January 30, 2013Date of Patent: January 13, 2015Assignee: Daiichi Sankyo Company, LimitedInventors: Hitoshi Ohki, Masahiro Ota, Kosuke Takeuchi, Hideaki Watanabe, Akitake Yamaguchi, Yoshihiro Shibata, Yuichi Tominaga, Takeshi Jimbo, Keijiro Kobayashi, Katsuhiro Kobayashi, Daisuke Fukatsu
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Publication number: 20140371249Abstract: To provide a crystal of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90. The present invention provides a crystal of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a medicament comprising the same, an anticancer agent comprising the same, and the like.Type: ApplicationFiled: August 29, 2014Publication date: December 18, 2014Applicant: Daiichi Sankyo Company, LimitedInventors: Yasusi Ueda, Nobuyuki Suzuki, Hitoshi Ohki
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Patent number: 8846703Abstract: To provide a crystal of a tricyclic pyrazolopyrimidine compound inhibiting the effect of HSP90. The present invention provides a crystal of 2-{4-amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide which inhibits the ATPase activity of HSP90 and which has antitumor activity, a medicament comprising the same, an anticancer agent comprising the same, and the like.Type: GrantFiled: February 21, 2013Date of Patent: September 30, 2014Assignee: Daiichi Sankyo Company, LimitedInventors: Yasusi Ueda, Nobuyuki Suzuki, Hitoshi Ohki
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Publication number: 20130281428Abstract: Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.Type: ApplicationFiled: January 30, 2013Publication date: October 24, 2013Inventors: Hitoshi Ohki, Masahiro Ota, Kosuke Takeuchi, Hideaki Watanabe, Akitake Yamaguchi, Yoshihiro Shibata, Yuichi Tominaga, Takeshi Jimbo, Keijiro Kobayashi, Katsuhiro Kobayashi, Daisuke Fukatsu
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Patent number: 8556332Abstract: A vehicle door includes a door main body having a hollow portion, a work hole, a door hole seal that covers the work hole, a door trim, a protruding member provided so as to protrude from the door trim toward the vehicle interior side surface, and a harness routed through the door hole seal to the door trim side. The door hole seal is provided with a general surface, a bulging portion facing the protruding member and bulging from the general surface toward the inside of the hollow portion, and a harness pull-out hole through which the harness is passed. The bulging portion has an inclined surface.Type: GrantFiled: September 7, 2012Date of Patent: October 15, 2013Assignee: Honda Motor Co., LtdInventors: Atsushi Nakashima, Hitoshi Ohki
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Patent number: 8445504Abstract: A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).Type: GrantFiled: April 20, 2012Date of Patent: May 21, 2013Assignee: Daiichi Sankyo Company, LimitedInventors: Hitoshi Ohki, Tooru Okayama, Masahiro Ikeda, Masahiro Ota, Yoshihiro Shibata, Toshiyuki Nakanishi, Yasusi Ueda, Nobuyuki Suzuki, Shinji Matuura
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Publication number: 20130076060Abstract: A vehicle door includes a door main body having a hollow portion, a work hole, a door hole seal that covers the work hole, a door trim, a protruding member provided so as to protrude from the door trim toward the vehicle interior side surface, and a harness routed through the door hole seal to the door trim side. The door hole seal is provided with a general surface, a bulging portion facing the protruding member and bulging from the general surface toward the inside of the hollow portion, and a harness pull-out hole through which the harness is passed. The bulging portion has an inclined surface.Type: ApplicationFiled: September 7, 2012Publication date: March 28, 2013Applicant: HONDA MOTOR CO., LTDInventors: Atsushi Nakashima, Hitoshi Ohki
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Publication number: 20120202833Abstract: A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).Type: ApplicationFiled: April 20, 2012Publication date: August 9, 2012Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Hitoshi Ohki, Tooru Okayama, Masahiro Ikeda, Masahiro Ota, Yoshihiro Shibata, Toshiyuki Nakanishi, Yasusi Ueda, Nobuyuki Suzuki, Shinji Matuura
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Patent number: 8236813Abstract: A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).Type: GrantFiled: October 29, 2010Date of Patent: August 7, 2012Assignee: Daiichi Sankyo Company, LimitedInventors: Hitoshi Ohki, Tooru Okayama, Masahiro Ikeda, Masahiro Ota, Yoshihiro Shibata, Toshiyuki Nakanishi, Yasusi Ueda, Nobuyuki Suzuki, Shinji Matuura
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Publication number: 20110071170Abstract: A pyrazolopyrimidine compound represented by formula (1) that inhibits the function of HSP90 as a chaperone protein and that has antitumor activity, a medicament comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).Type: ApplicationFiled: October 29, 2010Publication date: March 24, 2011Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Hitoshi Ohki, Tooru Okayama, Masahiro Ikeda, Masahiro Ota, Yoshihiro Shibata, Toshiyuki Nakanishi, Yasusi Ueda, Nobuyuki Suzuki, Shinji Matuura
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Publication number: 20070191356Abstract: A quinolone antimicrobial agent having potent antimicrobial activity against gram positive and gram negative bacteria and having high safety is provided. A compound represented by the following formula (1): [Chemical formula 1] [wherein, R1: hydrogen, alkyl, cycloalkyl, or substituted carbonyl derived from amino acid, peptide or tripeptide; R2: hydrogen, alkyl, or cycloalkyl; R3: hydrogen, amino, halogen, or alkyl; R4: hydrogen, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl, or phenylalkyl; X, X1, X2: hydrogen or halogen] or salt thereof, or a hydrate thereof; and antimicrobial agent and therapeutic agent for infections, each containing the compound, salt thereof or a hydrate thereof.Type: ApplicationFiled: February 1, 2005Publication date: August 16, 2007Inventors: Makoto Takemura, Hitoshi Ohki
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Patent number: 6656952Abstract: An antibacterial drug having potent antibacterial activities upon various bacteria including resistant strains and high safety is disclosed, which comprises as an active ingredient, quinolone derivatives represented by the following formula (I), its salts or hydrates thereof: wherein R1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R2 represents a halogenomethoxyl group or an alkoxyl group, R3 represents an alkyl group, an alkenyl group, a halogenoalkyl group, a cyclic alkyl group, a heteroaryl group, an alkoxyl group or an alkylamino group, and R4 represents a hydrogen atom, a phenyl group, an acetoxymethyl group, a pivaloyloxymethyl group, an ethoxycarbonyl group, a choline group, a dimethylaminoethyl group, a 5-indanyl group, a phthalidinyl group, a 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl group, 3-acetoxy-2-oxobutyl group, an alkyl group, an alkoxylmethyl group or a phenylalkyl group. These substituents may further have additional substituents.Type: GrantFiled: December 23, 1999Date of Patent: December 2, 2003Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Makoto Takemura, Hisashi Takahashi, Hitoshi Ohki, Kenichi Kimura, Rie Miyauchi, Toshiyuki Takeda
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Patent number: 6586604Abstract: The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases.Type: GrantFiled: June 8, 2001Date of Patent: July 1, 2003Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Makoto Takemura, Hisashi Takahashi, Kenichi Kimura, Rie Miyauchi, Hitoshi Ohki, Katsuhiro Kawakami
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Patent number: 6573377Abstract: This invention provides compounds having antitumor effect, namely a compound represented by the following formula (I) or (Ia) having various substituents in which G and G1 are condensed tricyclic heterocyclic rings or salts thereof, and a compound represented by the following formula (Ib) having various substituents or salts thereof.Type: GrantFiled: January 24, 2001Date of Patent: June 3, 2003Assignee: Daiichi Pharmaceuticals Co., Ltd.Inventors: Akio Ejima, Satoru Ohsuki, Hitoshi Ohki, Hiroyuki Naito, Chie Makino
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Patent number: 6552018Abstract: The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)-1piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.Type: GrantFiled: October 17, 2000Date of Patent: April 22, 2003Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Akio Ejima, Satoru Ohsuki, Hitoshi Ohki, Hiroyuki Naito
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Patent number: 6469023Abstract: The present invention provides an antibacterial compound useful as medicines, animal drugs, fisheries drugs or antibacterial preservatives and to an antibacterial agent or preparation which contains the same, more particularly a compound which possesses high safety and excellent activity against a broad range of bacterial species including quinolone-resistant strains. A quinolone derivative of the following formula (I) which has a group derived from the heterocyclic spiro-compound at the 7-positioned R2 and the halogenocyclopropyl group at the N1-position, prefereably a compound of pure isomer, and an antibacterial agent containing the derivative compound.Type: GrantFiled: August 7, 1997Date of Patent: October 22, 2002Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Makoto Takemura, Youichi Kimura, Hitoshi Ohki
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Publication number: 20020077345Abstract: Antimicrobial agents being excellent in antimicrobial activity and safety.Type: ApplicationFiled: November 2, 2001Publication date: June 20, 2002Applicant: DAIICHI PHARMACEUTICAL CO., LTD.Inventors: Makoto Takemura, Hisashi Takahashi, Kazuyuki Sugita, Hitoshi Ohki, Satoru Miyauchi, Rie Miyauchi
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Publication number: 20020072608Abstract: An antibacterial drug having potent antibacterial activities upon various bacteria including resistant strains and high safety is disclosed, which comprises as an active ingredient, quinolone derivatives represented by the following formula (I), its salts or hydrates thereof: 1Type: ApplicationFiled: December 23, 1999Publication date: June 13, 2002Inventors: MAKOTO TAKEMURA, HISASHI TAKAHASHI, HITOSHI OHKI, KENICHI KIMURA, RIE MIYAUCHI, TOSHIYUKI TAKEDA