Patents by Inventor Hitoshi Shiku

Hitoshi Shiku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11542612
    Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: January 3, 2023
    Assignees: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED
    Inventors: Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku, Mayuko Terauchi, Noriko Taira, Ryota Kunikata, Atsushi Suda
  • Patent number: 11460437
    Abstract: Provided are a device and a method for rapidly and simply detecting endotoxin without using an expensive reagent. The endotoxin detection device includes: a region containing an electrolyte solution; a partitioning member that partitions the region into two compartments such that the two compartments are in communication via a nanopore; a first electrode that is disposed in a first compartment; a second electrode that is disposed in a second compartment and is electrically connected to the first electrode; an electrolyte solution flow generating means that causes electrolyte solution in the first compartment to move to the second compartment via the nanopore; an application means that applies voltage between the first electrode and the second electrode; and a monitoring means that monitors current.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: October 4, 2022
    Assignee: TOHOKU UNIVERSITY
    Inventors: Takahiro Ito, Kumi Inoue, Kentaro Ito, Hitoshi Shiku, Tomokazu Matsue
  • Publication number: 20220205116
    Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.
    Type: Application
    Filed: March 16, 2022
    Publication date: June 30, 2022
    Applicants: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED
    Inventors: Kosuke INO, Tomokazu MATSUE, Hitoshi SHIKU, Mayuko TERAUCHI, Noriko TAIRA, Ryota KUNIKATA, Atsushi SUDA
  • Publication number: 20220205115
    Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.
    Type: Application
    Filed: March 16, 2022
    Publication date: June 30, 2022
    Applicants: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED
    Inventors: Kosuke INO, Tomokazu MATSUE, Hitoshi SHIKU, Mayuko TERAUCHI, Noriko TAIRA, Ryota KUNIKATA, Atsushi SUDA
  • Patent number: 11326262
    Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: May 10, 2022
    Assignees: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED
    Inventors: Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku, Mayuko Terauchi, Noriko Taira, Ryota Kunikata, Atsushi Suda
  • Publication number: 20220042947
    Abstract: Provided are a device and a method for rapidly and simply detecting endotoxin without using an expensive reagent. The endotoxin detection device includes: a region containing an electrolyte solution; a partitioning member that partitions the region into two compartments such that the two compartments are in communication via a nanopore; a first electrode that is disposed in a first compartment; a second electrode that is disposed in a second compartment and is electrically connected to the first electrode; an electrolyte solution flow generating means that causes electrolyte solution in the first compartment to move to the second compartment via the nanopore; an application means that applies voltage between the first electrode and the second electrode; and a monitoring means that monitors current.
    Type: Application
    Filed: March 6, 2020
    Publication date: February 10, 2022
    Applicant: TOHOKU UNIVERSITY
    Inventors: Takahiro ITO, Kumi INOUE, Kentaro ITO, Hitoshi SHIKU, Tomokazu MATSUE
  • Publication number: 20200200742
    Abstract: An object of the present invention is to provide an improved detection method for a specimen substance in a sample. The present invention provides a multiphase polymer fine particle having two or more polymer phases formed by aggregation of two or more polymers, respectively, at least on a surface thereof, wherein a first polymer phase can bind to a specimen substance or a substance that can specifically bind to the specimen substance, and a second polymer phase has a labeling substance. By utilizing the fine particle, the specimen substance in the sample having a biological origin or the like can be quickly detected with high sensitivity.
    Type: Application
    Filed: April 20, 2018
    Publication date: June 25, 2020
    Applicants: HAPLOPHARMA INC., TOHOKU UNIVERSITY
    Inventors: Fumitoshi SATOH, Hiroshi YABU, Kumi INOUE, Satsuki SATO, Hitoshi SHIKU, Yasuhisa NEMOTO, Ikuma MAEDA
  • Patent number: 10620146
    Abstract: An electrode chip including one auxiliary cell and a plurality of measurement cells on a substrate, where the auxiliary cell includes a reference electrode, a counter electrode, and an auxiliary cell-side working electrode, the measurement cell includes a driving electrode and a measurement cell-side working electrode, and the auxiliary cell-side working electrode and the measurement cell-side working electrode are electrically connected.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: April 14, 2020
    Assignee: TOHOKU UNIVERSITY
    Inventors: Tomokazu Matsue, Kumi Inoue, Takahiro Ito, Hitoshi Shiku, Miho Ikegawa
  • Publication number: 20200040468
    Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.
    Type: Application
    Filed: January 24, 2018
    Publication date: February 6, 2020
    Applicants: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED
    Inventors: Kosuke INO, Tomokazu MATSUE, Hitoshi SHIKU, Mayuko TERAUCHI, Noriko TAIRA, Ryota KUNIKATA, Atsushi SUDA
  • Publication number: 20190017953
    Abstract: An electrode tip including one auxiliary cell and a plurality of measurement cells on a substrate, where the auxiliary cell includes a reference electrode, a counter electrode, and an auxiliary cell-side working electrode, the measurement cell includes a driving electrode and a measurement cell-side working electrode, and the auxiliary cell-side working electrode and the measurement cell-side working electrode are electrically connected.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 17, 2019
    Applicant: TOHOKU UNIVERSITY
    Inventors: Tomokazu MATSUE, Kumi INOUE, Takahiro ITO, Hitoshi SHIKU, Miho IKEGAWA
  • Publication number: 20090325256
    Abstract: Provided is a method for cell patterning, using an electrode substrate including a plurality of electrodes and a cell culture substrate disposed so as to face the electrode substrate, the method comprising the steps of: introducing a cell suspension containing cells into a region between the electrode substrate and the cell culture substrate; applying a voltage to the electrodes to generate a non-uniform electric field in the region; and arranging the cells at a position with low electric field strength on the cell culture substrate by utilizing negative dielectrophoresis so as to obtain the cell culture substrate on which the cells are arranged in a predetermined pattern.
    Type: Application
    Filed: August 3, 2007
    Publication date: December 31, 2009
    Applicant: TOHOKU UNIVERSITY
    Inventors: Tomoyuki Yasukawa, Masato Suzuki, Hitoshi Shiku, Yoshio Hori, Akiko Inagaki, Mariko Komabayashi, Tomokazu Matsue
  • Patent number: 5866321
    Abstract: An analyte and a reactant 3 that reacts with the analyte either directly or indirectly are allowed to react with each other on the analytical areas A of a substrate 1 and signals originating from the reaction are detected. In at least a signal detection step, either a signal generation-related portion 4x or a detector is provided in a portion that is opposed to the substrate 1 and high and low areas are formed in either the substrate 1 or the opposed portion or both in such a manner that the distance from each analytical area A of the substrate to the opposed portion is shorter than the distance from each of the non-analytical areas B of the substrate to the opposed portion, whereby signals originating from the reaction in the analytical areas A will be detected at higher intensities than signals originating from the reaction in the non-analytical areas B.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: February 2, 1999
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Tomokazu Matsue, Hitoshi Shiku, Isamu Uchida