Patents by Inventor Hitoshi Shiku
Hitoshi Shiku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11542612Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.Type: GrantFiled: March 16, 2022Date of Patent: January 3, 2023Assignees: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITEDInventors: Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku, Mayuko Terauchi, Noriko Taira, Ryota Kunikata, Atsushi Suda
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Patent number: 11460437Abstract: Provided are a device and a method for rapidly and simply detecting endotoxin without using an expensive reagent. The endotoxin detection device includes: a region containing an electrolyte solution; a partitioning member that partitions the region into two compartments such that the two compartments are in communication via a nanopore; a first electrode that is disposed in a first compartment; a second electrode that is disposed in a second compartment and is electrically connected to the first electrode; an electrolyte solution flow generating means that causes electrolyte solution in the first compartment to move to the second compartment via the nanopore; an application means that applies voltage between the first electrode and the second electrode; and a monitoring means that monitors current.Type: GrantFiled: March 6, 2020Date of Patent: October 4, 2022Assignee: TOHOKU UNIVERSITYInventors: Takahiro Ito, Kumi Inoue, Kentaro Ito, Hitoshi Shiku, Tomokazu Matsue
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Publication number: 20220205116Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.Type: ApplicationFiled: March 16, 2022Publication date: June 30, 2022Applicants: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITEDInventors: Kosuke INO, Tomokazu MATSUE, Hitoshi SHIKU, Mayuko TERAUCHI, Noriko TAIRA, Ryota KUNIKATA, Atsushi SUDA
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Publication number: 20220205115Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.Type: ApplicationFiled: March 16, 2022Publication date: June 30, 2022Applicants: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITEDInventors: Kosuke INO, Tomokazu MATSUE, Hitoshi SHIKU, Mayuko TERAUCHI, Noriko TAIRA, Ryota KUNIKATA, Atsushi SUDA
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Patent number: 11326262Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.Type: GrantFiled: January 24, 2018Date of Patent: May 10, 2022Assignees: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITEDInventors: Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku, Mayuko Terauchi, Noriko Taira, Ryota Kunikata, Atsushi Suda
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Publication number: 20220042947Abstract: Provided are a device and a method for rapidly and simply detecting endotoxin without using an expensive reagent. The endotoxin detection device includes: a region containing an electrolyte solution; a partitioning member that partitions the region into two compartments such that the two compartments are in communication via a nanopore; a first electrode that is disposed in a first compartment; a second electrode that is disposed in a second compartment and is electrically connected to the first electrode; an electrolyte solution flow generating means that causes electrolyte solution in the first compartment to move to the second compartment via the nanopore; an application means that applies voltage between the first electrode and the second electrode; and a monitoring means that monitors current.Type: ApplicationFiled: March 6, 2020Publication date: February 10, 2022Applicant: TOHOKU UNIVERSITYInventors: Takahiro ITO, Kumi INOUE, Kentaro ITO, Hitoshi SHIKU, Tomokazu MATSUE
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Publication number: 20200200742Abstract: An object of the present invention is to provide an improved detection method for a specimen substance in a sample. The present invention provides a multiphase polymer fine particle having two or more polymer phases formed by aggregation of two or more polymers, respectively, at least on a surface thereof, wherein a first polymer phase can bind to a specimen substance or a substance that can specifically bind to the specimen substance, and a second polymer phase has a labeling substance. By utilizing the fine particle, the specimen substance in the sample having a biological origin or the like can be quickly detected with high sensitivity.Type: ApplicationFiled: April 20, 2018Publication date: June 25, 2020Applicants: HAPLOPHARMA INC., TOHOKU UNIVERSITYInventors: Fumitoshi SATOH, Hiroshi YABU, Kumi INOUE, Satsuki SATO, Hitoshi SHIKU, Yasuhisa NEMOTO, Ikuma MAEDA
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Patent number: 10620146Abstract: An electrode chip including one auxiliary cell and a plurality of measurement cells on a substrate, where the auxiliary cell includes a reference electrode, a counter electrode, and an auxiliary cell-side working electrode, the measurement cell includes a driving electrode and a measurement cell-side working electrode, and the auxiliary cell-side working electrode and the measurement cell-side working electrode are electrically connected.Type: GrantFiled: September 14, 2018Date of Patent: April 14, 2020Assignee: TOHOKU UNIVERSITYInventors: Tomokazu Matsue, Kumi Inoue, Takahiro Ito, Hitoshi Shiku, Miho Ikegawa
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Publication number: 20200040468Abstract: A hydrogel is formed by a reaction which is induced, in an electrolytic solution, by an electrode product electrochemically generated by electrodes installed in the electrolytic solution. An apparatus including an electrolytic tank with a bottom surface on which a two-dimensional array of working electrodes is provided and a counter electrode installed in the electrolytic tank is prepared. An electrolytic solution containing a dissolved substance that causes electrolytic deposition of a hydrogel is housed in the electrolytic tank. By applying a predetermined voltage to one or more selected working electrodes of the two-dimensional array, a hydrogel with a two-dimensional pattern corresponding to the arrangement of the selected working electrodes is formed.Type: ApplicationFiled: January 24, 2018Publication date: February 6, 2020Applicants: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITEDInventors: Kosuke INO, Tomokazu MATSUE, Hitoshi SHIKU, Mayuko TERAUCHI, Noriko TAIRA, Ryota KUNIKATA, Atsushi SUDA
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Publication number: 20190017953Abstract: An electrode tip including one auxiliary cell and a plurality of measurement cells on a substrate, where the auxiliary cell includes a reference electrode, a counter electrode, and an auxiliary cell-side working electrode, the measurement cell includes a driving electrode and a measurement cell-side working electrode, and the auxiliary cell-side working electrode and the measurement cell-side working electrode are electrically connected.Type: ApplicationFiled: September 14, 2018Publication date: January 17, 2019Applicant: TOHOKU UNIVERSITYInventors: Tomokazu MATSUE, Kumi INOUE, Takahiro ITO, Hitoshi SHIKU, Miho IKEGAWA
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Publication number: 20090325256Abstract: Provided is a method for cell patterning, using an electrode substrate including a plurality of electrodes and a cell culture substrate disposed so as to face the electrode substrate, the method comprising the steps of: introducing a cell suspension containing cells into a region between the electrode substrate and the cell culture substrate; applying a voltage to the electrodes to generate a non-uniform electric field in the region; and arranging the cells at a position with low electric field strength on the cell culture substrate by utilizing negative dielectrophoresis so as to obtain the cell culture substrate on which the cells are arranged in a predetermined pattern.Type: ApplicationFiled: August 3, 2007Publication date: December 31, 2009Applicant: TOHOKU UNIVERSITYInventors: Tomoyuki Yasukawa, Masato Suzuki, Hitoshi Shiku, Yoshio Hori, Akiko Inagaki, Mariko Komabayashi, Tomokazu Matsue
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Patent number: 5866321Abstract: An analyte and a reactant 3 that reacts with the analyte either directly or indirectly are allowed to react with each other on the analytical areas A of a substrate 1 and signals originating from the reaction are detected. In at least a signal detection step, either a signal generation-related portion 4x or a detector is provided in a portion that is opposed to the substrate 1 and high and low areas are formed in either the substrate 1 or the opposed portion or both in such a manner that the distance from each analytical area A of the substrate to the opposed portion is shorter than the distance from each of the non-analytical areas B of the substrate to the opposed portion, whereby signals originating from the reaction in the analytical areas A will be detected at higher intensities than signals originating from the reaction in the non-analytical areas B.Type: GrantFiled: October 25, 1996Date of Patent: February 2, 1999Assignee: Mochida Pharmaceutical Co., Ltd.Inventors: Tomokazu Matsue, Hitoshi Shiku, Isamu Uchida