Patents by Inventor Hitoshi Shimada

Hitoshi Shimada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220380365
    Abstract: The present invention relates to the compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, Ring A is cycloalkylene or the like, L is single bond or the like, and R is methyl or the like, or a pharmaceutically acceptable salt thereof, which has an anticancer effect by inhibiting the binding between a MLL fusion protein that is fused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.
    Type: Application
    Filed: September 25, 2020
    Publication date: December 1, 2022
    Applicant: Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Seiji KAMIOKA, Naoaki SHIMADA, Wataru HIROSE, Hitoshi BAN
  • Patent number: 11514376
    Abstract: An airline ticket sales system having a stock recording unit retaining a stock of flights, and a destination candidate extraction unit including: receiving an input of at least one condition from a user via an information processing terminal, information about a destination airport being excluded from the condition; acquiring, from the stock recording unit, information about outbound candidate flights and inbound candidate flights satisfying the condition; extracting, as candidate airports, a predetermined number from airports common to arrival airports of the outbound candidate flights and departure airports of the inbound candidate flights; selecting, based on a predetermined criterion, one from round-trip candidate flights composed of combinations of the outbound candidate flights and the inbound candidate flights among the departure airports of the outbound candidate flights specified by the condition and the respective candidate airports; and regarding the selected one as a to-be-sold round-trip flight.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 29, 2022
    Assignee: Nomura Research Institute, Ltd.
    Inventors: Taro Morioka, Hiroyuki Nakamura, Akira Arai, Takashi Sagimori, Hitoshi Matsuo, Takeo Shimada
  • Patent number: 11493812
    Abstract: According to one embodiment, a display device includes a semiconductor layer, a first insulating layer, a gate electrode, a second insulating layer and a plurality of transparent conductive layers. The transparent conductive layers include a pixel electrode, a first conductive layer and a second conductive layer. The pixel electrode is in contact with the second conductive layer. The second conductive layer is in contact with the first conductive layer. The first conductive layer is brought into contact with a second region of the semiconductor layer through a first contact hole.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: November 8, 2022
    Assignee: JAPAN DISPLAY INC.
    Inventors: Isao Suzumura, Fumiya Kimura, Kazuhide Mochizuki, Hitoshi Tanaka, Kenichi Akutsu, Atsuko Shimada
  • Patent number: 11485323
    Abstract: A heater includes a heat generation element which includes a heater wire which spreads in a planar manner, and a metal plate serving as a heat dissipation element which includes a material having a high thermal conductivity, which is placed on a vehicle windowpane side of the heat generation element, which is heated by heat from the heat generation element, and which irradiates heat to the vehicle windowpane side. The vehicle windowpane is heated by the heat irradiated from the metal plate serving as the heat dissipation element.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: November 1, 2022
    Assignees: KOJIMA INDUSTRIES CORPORATION, TOKYO COSMOS ELECTRIC CO., LTD.
    Inventors: Kenichi Ooji, Hitoshi Shimada, Kazuya Shibata, Noritaka Terasawa, Masashi Kaji
  • Publication number: 20220288072
    Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.
    Type: Application
    Filed: May 23, 2022
    Publication date: September 15, 2022
    Applicant: Sumitomo Pharma Co., Ltd.
    Inventors: Seiji KAMIOKA, Hitoshi BAN, Naoaki SHIMADA, Wataru HIROSE, Akihiko ARAKAWA, Kazuto YAMAZAKI, Kenjiro HIRA
  • Publication number: 20220289976
    Abstract: Provided are: a thermosetting resin composition, for use in an organic material suited to high frequency use, that has outstanding low dielectric tangent, heat resistance, flexibility, and ease of workability; a thermosetting resin sheet; an electronic component; and an electronic device. The present invention is a thermosetting resin composition that includes the following constituents (A1)-(C). (A1) Polyimide resin: a polyimide resin including a diamine residue with formula (8) and/or formula (9) (in formula (8), a, b, c, and d are integers 1 or greater that meet the conditions a+b=6-17 and c+d=8-19, and the dashed lines denote carbon-carbon single bonds or carbon-carbon double bonds) (in formula (9), e, f, g, and h are integers 1 or greater that meet the conditions e+f=5-16 and g+h=8-19, and the dashed lines denote carbon-carbon single bonds or carbon-carbon double bonds).
    Type: Application
    Filed: September 25, 2020
    Publication date: September 15, 2022
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Hisashi OGASAWARA, Akira SHIMADA, Kazuyuki MATSUMURA, Yohei SAKABE, Hitoshi ARAKI, Masaya JUKEI
  • Publication number: 20220273649
    Abstract: The present disclosure provides a compound that exerts an anticancer action based on CHK1 inhibition. The present disclosure was completed by finding that a compound represented by formula (1) or a pharmaceutically acceptable salt thereof exhibits an excellent antitumor action by having a potent inhibitory action against CHK1: wherein R1, R2, L, V, W, and Q are as defined herein, X, Y, and Z each independently represent CR8 or a nitrogen atom, wherein X, Y, and Z are not simultaneously CR8, and R8 is as defined herein.
    Type: Application
    Filed: April 27, 2022
    Publication date: September 1, 2022
    Applicant: Sumitomo Pharma Co., Ltd.
    Inventors: Seiji KAMIOKA, Hitoshi BAN, Makoto MATSUOKA, Wataru HIROSE, Naoaki SHIMADA, Kento HAYASHI, Hiroki UMEHARA
  • Patent number: 11369605
    Abstract: The present invention relates to the compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: June 28, 2022
    Assignee: Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Seiji Kamioka, Hitoshi Ban, Naoaki Shimada, Wataru Hirose, Akihiko Arakawa, Kazuto Yamazaki, Kenjiro Hira
  • Publication number: 20220056020
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Application
    Filed: September 16, 2021
    Publication date: February 24, 2022
    Inventors: Makoto HIGUCHI, Tetsuya SUHARA, Masahiro MARUYAMA, Meiei CHO, Hitoshi SHIMADA
  • Patent number: 10876593
    Abstract: Provided is a vibration damping device that reduces parts cost and improves productivity. The vibration damping device includes: a mounting member (10) that is attached to a vibration source; a holder (20) that is attached to a vibration receiver; and an insulator (30) that connects the mounting member (10) with the holder (20), wherein the holder (20) has a base portion (21) to which an end of the insulator (30) is coupled and a stopper portion (22) that rises from the base portion (21), and the insulator (30) has a pair of rubber feet (31 a, 31 b) that faces each other at a distance, wherein the pair of rubber feet (31a, 31 b) defines a cavity (35) therebetween, and the base portion (21) has an opening (25) formed therein at a position corresponding to the cavity (35).
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: December 29, 2020
    Assignee: YAMASHITA RUBBER CO., LTD.
    Inventor: Hitoshi Shimada
  • Publication number: 20200262829
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and [Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Application
    Filed: February 21, 2020
    Publication date: August 20, 2020
    Inventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
  • Patent number: 10604516
    Abstract: The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and ??[Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 31, 2020
    Assignee: National Institutes for Quantum and Radiological Science and Technology
    Inventors: Makoto Higuchi, Tetsuya Suhara, Masahiro Maruyama, Meiei Cho, Hitoshi Shimada
  • Publication number: 20190176762
    Abstract: A heater includes a heat generation element which includes a heater wire which spreads in a planar manner, and a metal plate serving as a heat dissipation element which includes a material having a high thermal conductivity, which is placed on a vehicle windowpane side of the heat generation element, which is heated by heat from the heat generation element, and which irradiates heat to the vehicle windowpane side. The vehicle windowpane is heated by the heat irradiated from the metal plate serving as the heat dissipation element.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 13, 2019
    Inventors: Kenichi OOJI, Hitoshi SHIMADA, Kazuya SHIBATA, Noritaka TERASAWA, Masashi KAJI
  • Publication number: 20190113100
    Abstract: Provided is a vibration damping device that reduces parts cost and improves productivity. The vibration damping device includes: a mounting member (10) that is attached to a vibration source; a holder (20) that is attached to a vibration receiver; and an insulator (30) that connects the mounting member (10) with the holder (20), wherein the holder (20) has a base portion (21) to which an end of the insulator (30) is coupled and a stopper portion (22) that rises from the base portion (21), and the insulator (30) has a pair of rubber feet (31 a, 31 b) that faces each other at a distance, wherein the pair of rubber feet (31a, 31 b) defines a cavity (35) therebetween, and the base portion (21) has an opening (25) formed therein at a position corresponding to the cavity (35).
    Type: Application
    Filed: March 22, 2017
    Publication date: April 18, 2019
    Inventor: Hitoshi SHIMADA
  • Patent number: 10189781
    Abstract: The onium salt of the present invention contains predetermined compound A represented by the general formula (1). The composition of the present invention contains the onium salt of the present invention, and an onium salt containing predetermined compound B represented by the general formula (2). The onium salt and the composition of the present invention exert well-balanced excellent physical properties in terms of cold curing properties, storage stability, thermal shock resistance after curing, and moisture resistance.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: January 29, 2019
    Assignee: ASAHI KASEI E-MATERIALS CORPORATION
    Inventors: Tadashi Shimura, Naoya Kamimura, Akira Otani, Hitoshi Shimada
  • Patent number: 10124431
    Abstract: A wire (12) is wound around multiple processing rollers (11) several times. A holding mechanism (13) and a depressing mechanism (25) are provided above an area where the wire (12) is wound. The holding mechanism (13) holds a workpiece (W) elastically and laterally. The depressing mechanism (25) depresses the workpiece (W) held by the holding mechanism (13) toward the wire (12).
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: November 13, 2018
    Assignee: Komatsu NTC Ltd.
    Inventors: Hitoshi Shimada, Tomoyuki Kawatsu, Yosuke Yabu, Akira Tanizaki
  • Patent number: 9709116
    Abstract: A large ring part of a torque rod includes an outer frame section, an inner member, an intermediate ring and an elastic vibration isolating main body. The outer frame section and the intermediate ring are integrally combined with the elastic vibration isolating main body. An inner clearance is provided between the intermediate ring and the inner member such as to surround the circumference of the inner member. The intermediate ring is movable relative to the inner member in the axial direction. With respect to the vibration in the direction of a mounting shaft, the outer frame section, the intermediate ring and the elastic vibration isolating main body move together in the axial direction in relation to the inner member, whereby the spring in the direction of the mounting shaft is weakened and the resonance frequency of the rigid body resonance in the direction of the mounting shaft is decreased.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: July 18, 2017
    Assignee: YAMASHITA RUBBER KABUSHIKI KAISHA
    Inventor: Hitoshi Shimada
  • Patent number: 9611916
    Abstract: A second inner member and a second insulator are provided in a second ring-shaped member forming a torque rod. A first bore section and a second bore section are provided in front of and in the rear of the second inner member. The insulator has an elastic arm section extending in the direction of a Y axis. A spring adjustment recess extends in a slit shape in the direction of an X axis from an end of the first bore section. The spring adjustment recess forms an unrestricted part of the elastic arm section by the second ring-shaped member, whereby the Z spring in the axial direction of the inner member is lowered, and the XZ spring ratio can be changed greatly while maintaining the size of the X spring in the main vibration inputting direction.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: April 4, 2017
    Assignee: YAMASHITA RUBBER KABUSHIKI KAISHA
    Inventor: Hitoshi Shimada
  • Patent number: 9470289
    Abstract: A torque rod includes a rod main body, a first bushing and a second bushing. The rod main body is made of resin and provided integral with a first ring section and a second ring section on each end of an arm section. A first rib extends from the arm section to a front lateral surface of the second ring section. In a plan view, a second rib is provided to overlap with the first rib. The first rib projects forwardly of and in the left and right directions of the second rib. This projecting portion forms an enlarged diameter portion. Due to this enlarged diameter portion, an area of the first rib is made larger than an area of the second rib thereby to increase a rigidity of a forward side of the second ring.
    Type: Grant
    Filed: August 10, 2013
    Date of Patent: October 18, 2016
    Assignee: YAMASHITA RUBBER KABUSHIKI KAISHA
    Inventor: Hitoshi Shimada
  • Publication number: 20160229801
    Abstract: The onium salt of the present invention contains predetermined compound A represented by the general formula (1). The composition of the present invention contains the onium salt of the present invention, and an onium salt containing predetermined compound B represented by the general formula (2). The onium salt and the composition of the present invention exert well-balanced excellent physical properties in terms of cold curing properties, storage stability, thermal shock resistance after curing, and moisture resistance.
    Type: Application
    Filed: September 24, 2014
    Publication date: August 11, 2016
    Applicant: ASAHI KASEI E-MATERIALS CORPORATION
    Inventors: Tadashi SHIMURA, Naoya KAMIMURA, Akira OTANI, Hitoshi SHIMADA