Abstract: Systems and methods for quantitatively optimizing the design of prosthetic sockets are disclosed herein. An example method may involve receiving data indicating a first prosthetic socket design for a first patient and data associated with the first patient. The example method may also involve receiving data indicating a structure of an second prosthetic socket design for a second patient and data associated with the second patient. The example method may also involve determining, based on the data associated with the first patient, the data indicating the structure of the optimized prosthetic socket for the second patient, and the data associated with the second patient, an third prosthetic socket design for the first patient. The example method may also involve providing, based on the third prosthetic socket design for the first patient, an output indicating an area of the first prosthetic socket design to add or remove material.