Patents by Inventor Ho-Chang KUO

Ho-Chang KUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and kits for diagnosing kawasaki disease and methods for treating kawasaki disease
    Patent number: 11377691
    Abstract: The present invention relates to methods that use novel biomarkers for diagnosing and/or treating Kawasaki diseases. The novel biomarkers of the invention show altered cytosine methylations state of certain CpG loci in subject with Kawasaki Disease relative to subject without Kawasaki diseases. Also provided are kits comprising at least one primer or reagent specific for the altered cytosine methylation state of certain CpG loci to detect Kawasaki Disease.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: July 5, 2022
    Assignee: Chang Gung Memorial Hospital, Kaohsiung
    Inventors: Ying-Hsien Huang, Ho-Chang Kuo
  • Diagnosis and treatment of Kawasaki disease
    Patent number: 10983133
    Abstract: Described is a method of diagnosing, treating, or monitoring a treatment for Kawasaki disease in a subject. The method includes detecting the level of a biomarker in a sample obtained from the subject, the biomarker being IL-7F, sCD40L, MPIF-1, E-selectin, IP-10, or IL-33. The level is compared to a cut-off level. Also described is a kit for carrying out the method.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: April 20, 2021
    Assignee: Academia Sinica
    Inventors: Yuan-Tsong Chen, Jer-Yuarn Wu, Tai-Ming Ko, Ho-Chang Kuo, Jeng-Sheng Chang
  • METHODS FOR IDENTIFYING AND TREATING KAWASAKI DISEASE PATIENTS WITH INTRAVENOUS IMMUNOGLOBULIN RESISTANCE
    Publication number: 20200095638
    Abstract: Methods for identifying Kawasaki Disease subjects resistant to intravenous immunoglobulin (IVIG) are provided, comprising the step of detecting at least one risk allele of the SNPs disclosed herein or calculating a weighted genetic risk score based on the presence of the risk alleles. Also provided are methods of treating Kawasaki Disease subjects with IVIG resistance, by administering a first dose of IVIG and an adjunctive therapy.
    Type: Application
    Filed: September 25, 2018
    Publication date: March 26, 2020
    Inventors: Ho-Chang KUO, Kai-Sheng HSIEH, Wei Chiao CHANG, Henry Sung-Ching WONG
  • Methods and kits for detecting Kawasaki disease
    Patent number: 10358676
    Abstract: Kits for detecting Kawasaki disease, containing an agent for sequencing or measuring the expression level of one or more of the following: miR-941, miR-182-5p and miR-183-5p are provided. Methods for detecting Kawasaki disease in a subject, comprising the identifying of one or more of the following in the subject: miR-941, miR-182-5p and miR-183-5p, are also provided.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: July 23, 2019
    Assignee: Kaohsiung Chang Gung Memorial Hospital
    Inventors: Ho-Chang Kuo, Sung-Chou Li, Wen-Ching Chan
  • METHODS AND KITS FOR DIAGNOSING KAWASAKI DISEASE AND METHODS FOR TREATING KAWASAKI DISEASE
    Publication number: 20190153081
    Abstract: The present invention relates to methods that use novel biomarkers for diagnosing and/or treating Kawasaki diseases. The novel biomarkers of the invention show altered cytosine methylations state of certain CpG loci in subject with Kawasaki Disease relative to subject without Kawasaki diseases. Also provided are kits comprising at least one primer or reagent specific for the altered cytosine methylation state of certain CpG loci to detect Kawasaki Disease.
    Type: Application
    Filed: November 20, 2018
    Publication date: May 23, 2019
    Inventors: Ying-Hsien HUANG, Ho-Chang KUO
  • METHODS AND KITS FOR DETECTNG ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
    Publication number: 20180251834
    Abstract: Kits for detecting Attention-Deficit/Hyperactivity Disorder (ADHD), containing an agent for sequencing or measuring the expression level of one or more miRNAs provided. Methods for diagnosing ADHD in a subject in need of such diagnosis are also provided, comprising measuring the expression level of one or more miRNAs in the sample of the subject.
    Type: Application
    Filed: March 1, 2018
    Publication date: September 6, 2018
    Inventors: Liang-Jen WANG, Sung-Chou LI, Ho-Chang KUO
  • DIAGNOSIS AND TREATMENT OF KAWASAKI DISEASE
    Publication number: 20170153250
    Abstract: Described is a method of diagnosing, treating, or monitoring a treatment for Kawasaki disease in a subject. The method includes detecting the level of a biomarker in a sample obtained from the subject, the biomarker being IL-7F, sCD40L, MPIF-1, E-selectin, IP-10, or IL-33. The level is compared to a cut-off level. Also described is a kit for carrying out the method.
    Type: Application
    Filed: July 23, 2015
    Publication date: June 1, 2017
    Inventors: Yuan-Tsong Chen, Jer-Yuarn Wu, Tai-Ming Ko, Ho-Chang Kuo, Jeng-Sheng Chang
  • METHODS AND KITS FOR DETECTING KAWASAKI DISEASE
    Publication number: 20160289764
    Abstract: Kits for detecting Kawasaki disease, containing an agent for sequencing or measuring the expression level of one or more of the following: miR-941, miR-182-5p and miR-183-5p are provided. Methods for detecting Kawasaki disease in a subject, comprising the identifying of one or more of the following in the subject: miR-941, miR-182-5p and miR-183-5p, are also provided.
    Type: Application
    Filed: February 25, 2016
    Publication date: October 6, 2016
    Inventors: Ho-Chang KUO, Sung-Chou LI, Wen-Ching CHAN