Patents by Inventor Ho-Chuan Shen

Ho-Chuan Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof
    Patent number: 8927584
    Abstract: The present invention provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein R1 and R2 are defined as the above) in a pharmaceutically acceptable carrier to the patient; waiting for a sufficient time to allow the administered compound to be taken up by a target tissue having the at least one tumor; and irradiating a region of the patient containing the target tissue, wherein growth of the tumor is inhibited.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: January 6, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Jeh-Jeng Wang, Chao-Cheng Liao, Wan-Ping Hu, Ho-Chuan Shen
  • SYNTHESIS OF 2-(4-AMINOPHENYL)BENZOTHIAZOLE DERIVATIVES AND USE THEREOF
    Publication number: 20140046290
    Abstract: The present invention provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein R1 and R2 are defined as the above) in a pharmaceutically acceptable carrier to the patient; waiting for a sufficient time to allow the administered compound to be taken up by a target tissue having the at least one tumor; and irradiating a region of the patient containing the target tissue, wherein growth of the tumor is inhibited.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Jeh-Jeng Wang, Chao-Cheng Liao, Wan-Ping Hu, Ho-Chuan Shen
  • Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof
    Patent number: 8592603
    Abstract: The present invention provides a method of preparing a compound of formula 6 comprising: (a) reacting a compound of formula 1 with a compound of formula 2 to form a compound of formula 3 wherein X of formula 2 is Cl or OH; (b) treating the compound formula 3 with Lawesson's reagent to form a compound of formula 4 (c) reacting a compound of formula 4 with potassium ferricyanide to produce a compound of formula 5 and (d) performing catalytic reduction of nitro group of the compound of formula 5 with palladium on charcoal to generate the compound of formula 6, wherein R1 of formulae 1-6 is H, C1-10 alkyl, C1-10 alkoxy or C1-10 haloalkyl, and R2 of formulae 1-6 is H or C1-10 alkyl.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: November 26, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Jeh-Jeng Wang, Chao-Cheng Liao, Wan-Ping Hu, Ho-Chuan Shen
  • SYNTHESIS OF 2-(4-AMINOPHENYL) BENZOTHIAZOLE DERIVATIVES AND USE THEREOF
    Publication number: 20120215154
    Abstract: The present invention provides a method of preparing a compound of formula 6 comprising: (a) reacting a compound of formula 1 with a compound of formula 2 to form a compound of formula 3 wherein X of formula 2 is Cl or OH; (b) treating the compound formula 3 with Lawesson's reagent to form a compound of formula 4 (c) reacting a compound of formula 4 with potassium ferricyanide to produce a compound of formula 5 and (d) performing catalytic reduction of nitro group of the compound of formula 5 with palladium on charcoal to generate the compound of formula 6, wherein R1 of formulae 1-6 is H, C1-10 alkyl, C1-10 alkoxy or C1-10 haloalkyl, and R2 of formulae 1-6 is H or C1-10 alkyl.
    Type: Application
    Filed: February 22, 2011
    Publication date: August 23, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Jeh-Jeng Wang, Chao-Cheng Liao, Wan-Ping Hu, Ho-Chuan Shen