Patents by Inventor Ho-Juhn Song
Ho-Juhn Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240101682Abstract: The present disclosure provides bispecific antibodies, and compositions and methods of treating cancer incorporating said bispecific antibodies. The bispecific antibodies include a polypeptide comprising an EGFR-binding domain and a neuropilin (NRP1)-specific binding domain at the C-terminal end. Monoclonal antibodies that specifically bind NRP1 are also provided.Type: ApplicationFiled: March 30, 2023Publication date: March 28, 2024Inventor: Ho-Juhn SONG
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Publication number: 20230312684Abstract: The present disclosure relates to fusion protein compositions and methods of reducing and treating viral infections. The fusion proteins include a polypeptide comprising a b1 domain, or a derivative or fragment thereof, of a neuropilin; an ACE2 domain, or a derivative or a fragment thereof, of an angiotensin converting enzyme 2; and or an immunoglobulin domain. Both the b1 and ACE2 domains are capable of binding to a coat protein of a virus selected from the group consisting of herpesviridae, papillomaviridae, coronaviridae, flaviviridae, togaviridae, bomaviridae, bunyaviridae, filoviridae, orthomyxoviridae, paramyxoviridae, pneumoviridae, and retro viridae. In some embodiments, the b1 domain, or a derivative or fragment thereof, and/or the (ACE2) domain, can be used to specifically bind S proteins of COVID-19 particles.Type: ApplicationFiled: August 2, 2021Publication date: October 5, 2023Inventors: Ho Juhn SONG, Euijoon JEONG, Anthony John ROSSOMANDO, Sung Hugh CHOI, Clemens REINSHAGEN, Yongbin TAK, DeLuna XAVIER, Chikwamba KUDZAI
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Patent number: 9593098Abstract: The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer and immune disease. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefore. The invention also provides useful intermediates generated during the syntheses of the aminopyrimidine derivatives.Type: GrantFiled: October 13, 2015Date of Patent: March 14, 2017Assignee: Yuhan CorporationInventors: Byung-Chul Suh, Paresh Devidas Salgaonkar, Jaekyoo Lee, Jong Sung Koh, Ho-Juhn Song, In Yong Lee, Jaesang Lee, Dong Sik Jung, Jung-Ho Kim, Se-Won Kim
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Publication number: 20160102076Abstract: The present invention provides a new group of protein kinase inhibitors, aminopyrimidine derivatives, and pharmaceutically acceptable salts thereof that are useful for treating cell proliferative disease and disorder such as cancer and immune disease. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefore. The invention also provides useful intermediates generated during the syntheses of the aminopyrimidine derivatives.Type: ApplicationFiled: October 13, 2015Publication date: April 14, 2016Inventors: Byung-Chul Suh, Paresh Devidas Salgaonkar, Jaekyoo Lee, Jong Sung Koh, Ho-Juhn Song, In Yong Lee, Jaesang Lee, Dong Sik Jung, Jung-Ho Kim, Se-Won Kim
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Patent number: 9212178Abstract: Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).Type: GrantFiled: October 21, 2014Date of Patent: December 15, 2015Assignees: Genosco, Oscotec, Inc.Inventors: Jaekyoo Lee, Jang-Sik Choi, Hae-Jun Hwang, Ho-Juhn Song, Jung-Ho Kim, Se-Won Kim, Jong Sung Koh, Jaesang Lee, Tae-Im Lee, Yung-Geun Choi, Sung-Ho Park, In Yong Lee, Byung-Chul Suh, Paresh Devidas Salgaonkar, Dong-Sik Jung
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Publication number: 20150111883Abstract: Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).Type: ApplicationFiled: October 21, 2014Publication date: April 23, 2015Inventors: Jaekyoo Lee, Jang-Sik Choi, Hae-Jun Hwang, Ho-Juhn Song, Jung-Ho Kim, Se-Won Kim, Jong Sung Koh, Jaesang Lee, Tae-Im Lee, Yung-Geun Choi, Sung-Ho Park, In Yong Lee, Byung-Chul Suh, Paresh Devidas Salgaonkar, Dong-Sik Jung
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Patent number: 8877763Abstract: Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).Type: GrantFiled: March 15, 2013Date of Patent: November 4, 2014Assignees: Genosco, Oscotec, Inc.Inventors: Hong Woo Kim, Hee Kyu Lee, Ho-Juhn Song, Jaekyoo Lee, Jong Sung Koh, Jung-Ho Kim, Se Won Kim, In Yong Lee
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Patent number: 8871778Abstract: Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).Type: GrantFiled: January 18, 2013Date of Patent: October 28, 2014Assignees: Genosco, Oscotec, Inc.Inventors: Jang-Sik Choi, Hae-Jun Hwang, Eunho Lee, Jaekyoo Lee, Ho-Juhn Song, Se Won Kim, Jung-Ho Kim, Jong Sung Koh, Tae-im Lee, Yung-geun Choi, Ik-hwan Han, Jaesang Lee, In Yong Lee, Dong Sik Jung
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Patent number: 8629132Abstract: The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.Type: GrantFiled: November 12, 2010Date of Patent: January 14, 2014Assignees: Genosco, Oscotec, Inc.Inventors: Jaekyoo Lee, Ho-Juhn Song, Jong Sung Koh, Hee Kyu Lee, Youngsam Kim, Hong Woo Kim, Sunhwa Chang, Sun-Hee Lim, Jang-Sik Choi, Jung-Ho Kim, Se-Won Kim
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Publication number: 20130274242Abstract: Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).Type: ApplicationFiled: January 18, 2013Publication date: October 17, 2013Inventors: Jang-Sik Choi, Hae-Jun Hwang, Eunho Lee, Jaekyoo Lee, Ho-Juhn Song, Se Won Kim, Jung-Ho Kim, Jong Sung Koh, Sunhwa Chang, Tae-im Lee, Yung-geun Choi, Ik-hwan Han, Jaesang Lee
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Publication number: 20130274274Abstract: Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).Type: ApplicationFiled: March 15, 2013Publication date: October 17, 2013Inventors: Hong Woo Kim, Hee Kyu Lee, Ho-Juhn Song, Jaekyoo Lee, Jong Sung Koh, Youngsam Kim, Jung-Ho Kim, Se Won Kim, In Yong Lee
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Patent number: 8404677Abstract: The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.Type: GrantFiled: October 29, 2010Date of Patent: March 26, 2013Assignees: Genosco, Oscotec, Inc.Inventors: Hong Woo Kim, Jong Sung Koh, Jaekyoo Lee, Ho-Juhn Song, Youngsam Kim, Hee Kyu Lee, Jang-Sik Choi, Sun-Hee Lim, Sunhwa Chang
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Publication number: 20110281841Abstract: The present invention provides a new group of protein kinase inhibitors, pyrropyrimidine and pyrazolopyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof that are useful for treating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrropyrimidine and pyrazolopyrimidine derivatives.Type: ApplicationFiled: November 12, 2010Publication date: November 17, 2011Applicants: Oscotec, Inc., GenoscoInventors: Jaekyoo Lee, Ho-Juhn Song, Jong Sung Kon, Hee Kyu Lee, Yougsam Kim, Hong Woo Kim, Sunhwa Chang, Sun-Hee Lim, Jang-Sik Choi, Jung-Ho Kim, Se-Won Kim
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Publication number: 20110269739Abstract: The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.Type: ApplicationFiled: October 29, 2010Publication date: November 3, 2011Applicants: Oscotec, Inc., GenoscoInventors: Hong Woo Kim, Jong Sung Koh, Jaekyoo Lee, Ho-Juhn Song, Youngsam Kim, Hee Kyu Lee, Jang-Sik Choi, Sun-Hee Lim, Sunhwa Chang
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Publication number: 20090016963Abstract: The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate neurodegenerative conditions. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat neurodegenerative conditions.Type: ApplicationFiled: October 21, 2004Publication date: January 15, 2009Inventors: Dalia Cohen, Uwe Jochen Dengler, Danny Garza, Anju N. Kelkar, Mary Konsolaki, Ho-Juhn Song
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Publication number: 20080152644Abstract: The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate neurodegenerative conditions. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat neurodegenerative conditions.Type: ApplicationFiled: March 3, 2006Publication date: June 26, 2008Inventors: Ho-Juhn Song, Anju N. Kelkar, Dan Garza, Mary Konsolaki