Patents by Inventor Ho Pui Ho
Ho Pui Ho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220314313Abstract: Fluorinated metal nanoparticles (f-MNPs) are metal nanoparticles and/or semiconductor nanoparticles having a plurality of fluorinated alkyl ligands attached to the surfaces of the nanoparticles where the f-MNPs are greater than 20 nm in cross-section. The f-MNPs can be used as a surfactant to form active f-MNPs stabilized aqueous droplet, which can be used in a light-mediated microfluidic device where droplet movement, merging, splitting, and sorting can be carried out as directed by one or more laser beams focused onto one or more spots of light-mediated microfluidic device.Type: ApplicationFiled: August 24, 2020Publication date: October 6, 2022Inventors: Yi-Ping HO, Guangyao CHENG, Sebastian BEYER, Ho Pui HO, To NGAI, Kuan Ting LIN
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Patent number: 10384209Abstract: A microfluidic platform including a microfluidic layer and a contact layer. The microfluidic layer is embedded with a microfluidic structure including a micro-channel and a fluidic sample contained in the micro-channel. The contact layer is able to be attached to the microfluidic layer, and includes a first heater for heating a first area of the microfluidic structure to a first temperature and a second heater for heating a second area of the microfluidic structure to a second temperature. The microfluidic layer and the contact layer rotate together during operation. A method for controlling a sample in the micro-channel of the microfluidic structure.Type: GrantFiled: September 10, 2012Date of Patent: August 20, 2019Assignees: THE CHINESE UNIVERSITY OF HONG KONG, NANYANG TECHNOLOGICAL UNIVERSITY, HOSPITAL AUTHORITYInventors: Qiu Lan Chen, Ho Pui Ho, Siu Kai Kong, Patrick Kwok Leung Kwan, Yiu Wa Kwan, Ho Chin Kwok, Ping Shum, Yick Keung Suen, Shu Yuen Wu, Alice Kar Lai Yang, Jun Qiang Zhou
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Patent number: 10220388Abstract: The disclosure provides a centrifugal microfluidics control system and a method configuring the same. The system may comprise a centrifugal tube; a centrifugal unit for accommodating the centrifugal tube and providing a centrifugal force to the centrifugal tube; a control unit fixed in bottom of the centrifugal tube; and a microfluidic supporting unit coupled to the control unit in the centrifugal tube. The control unit may change an orientation of the microfluidic supporting unit to change a direction of the centrifugal force applied to the microfluidic supporting unit.Type: GrantFiled: August 8, 2016Date of Patent: March 5, 2019Assignees: The Chinese University of Hong Kong, Nanjing UniversityInventors: Minghui Tang, Ho-Pui Ho, Guanghui Wang, Siu-Kai Kong, Fong-Chuen Loo, Ho Chin Kwok, Shu-Yuen Wu, Xuping Zhang
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Publication number: 20180036728Abstract: The disclosure provides a centrifugal microfluidics control system and a method configuring the same. The system may comprise a centrifugal tube; a centrifugal unit for accommodating the centrifugal tube and providing a centrifugal force to the centrifugal tube; a control unit fixed in bottom of the centrifugal tube; and a microfluidic supporting unit coupled to the control unit in the centrifugal tube. The control unit may change an orientation of the microfluidic supporting unit to change a direction of the centrifugal force applied to the microfluidic supporting unit.Type: ApplicationFiled: August 8, 2016Publication date: February 8, 2018Inventors: Minghui TANG, Ho-Pui HO, Guanghui WANG, Siu-Kai KONG, Fong-Chuen LOO, Ho Chin KWOK, Shu-Yuen WU, Xuping ZHANG
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Patent number: 9322778Abstract: An optical sensing apparatus and a method for detecting characteristics of a sample.Type: GrantFiled: April 23, 2015Date of Patent: April 26, 2016Assignees: THE CHINESE UNIVERSITY OF HONG KONG, CITY UNIVERSITY OF HONG KONGInventors: Ho Pui Ho, Shu Yuen Wu, Chi-Man Lawrence Wu, Siu Pang Ng, Siu Kai Kong
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Publication number: 20150308950Abstract: An optical sensing apparatus and a method for detecting characteristics of a sample.Type: ApplicationFiled: April 23, 2015Publication date: October 29, 2015Inventors: Ho Pui Ho, Shu Yuen Wu, Chi-Man Lawrence Wu, Siu Pang Ng, Siu Kai Kong
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Patent number: 8988688Abstract: Disclosed are optical sensing devices and methods for detecting samples using the same. The optical sensing device comprises a source unit configured to generate a polychromatic light beam containing p-polarized and s-polarized components; an interferometric unit configured to split the light beam into a probe beam passing a first path and a reference beam passing a second path and to recombine the probe beam output from the first path and the reference beam output from the second path; a sensing unit disposed in the first path to introduce a first SPR effect associated with a target sample to the probe beam; and a detection unit configured to detect target sample characteristics by obtaining an intensity spectrum of the recombined light beam. The introduction of a polychromatic light source in the optical sensing device increases the detection dynamic range and the detection sensitivity.Type: GrantFiled: May 23, 2011Date of Patent: March 24, 2015Assignees: The Chinese University of Hong Kong, City University of Hong KongInventors: Lawrence Chi-man Wu, Siu pang Ng, Ho Pui Ho, Shu Yuen Wu
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Patent number: 8953168Abstract: An optical sensing device including a source unit configured to generate a polychromatic light beam containing p-polarized beam and s-polarized beam; an interferometric unit configured to introduce birefringent retardation for generating optical path difference between the p-polarized beam and the s-polarized beam; a SPR sensing unit configured to receive both p-polarized beam and s-polarized beam and induce a SPR effect to the p-polarized beam associated with a target sample; and a detection unit for detecting target sample characteristics by obtaining an interference spectrum of the p-polarized beam and the s-polarized beam from the SPR sensing unit.Type: GrantFiled: June 8, 2012Date of Patent: February 10, 2015Assignees: City University of Hong Kong, The Chinese University of Hong KongInventors: Shu Yuen Wu, Ho Pui Ho, Chi-man Lawrence Wu, Siu-pang Ng
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Publication number: 20150027555Abstract: A microfluidic platform including a microfluidic layer and a contact layer. The microfluidic layer is embedded with a microfluidic structure including a micro-channel and a fluidic sample contained in the micro-channel. The contact layer is able to be attached to the microfluidic layer, and includes a first heater for heating a first area of the microfluidic structure to a first temperature and a second heater for heating a second area of the microfluidic structure to a second temperature. The microfluidic layer and the contact layer rotate together during operation. A method for controlling a sample in the micro-channel of the microfluidic structure.Type: ApplicationFiled: September 10, 2012Publication date: January 29, 2015Applicants: THE CHINESE UNIVERSITY OF HONG KONG, NANYANG TECHNOLOGICAL UNIVERSITY, HOSPITAL AUTHORITYInventors: Qiu Lan Chen, Ho Pui Ho, Siu Kai Kong, Patrick Kwok Leung Kwan, Yiu Wa Kwan, Ho Chin Kwok, Ping Shum, Yick Keung Suen, Shu Yuen Wu, Alice Kar Lai Yang, Jun Qiang Zhou
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Publication number: 20130329230Abstract: An optical sensing device including a source unit configured to generate a polychromatic light beam containing p-polarized beam and s-polarized beam; an interferometric unit configured to introduce birefringent retardation for generating optical path difference between the p-polarized beam and the s-polarized beam; a SPR sensing unit configured to receive both p-polarized beam and s-polarized beam and induce a SPR effect to the p-polarized beam associated with a target sample; and a detection unit for detecting target sample characteristics by obtaining an interference spectrum of the p-polarized beam and the s-polarized beam from the SPR sensing unit.Type: ApplicationFiled: June 8, 2012Publication date: December 12, 2013Applicants: City University of Hong Kong, The Chinese University of Hong KongInventors: Shu Yuen Wu, Ho Pui Ho, Chi-man Lawrence Wu, Siu-pang Ng
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Patent number: 8169617Abstract: There is disclosed a phase sensitive surface plasmon resonance sensing apparatus wherein a testing beam may be reflected from a sensing surface at a plurality of angles. There are also disclosed methods for surface plasmon resonance sensing.Type: GrantFiled: March 20, 2009Date of Patent: May 1, 2012Assignee: The Chinese University of Hong KongInventors: Ho Pui Ho, Siu Kai Kong, Yick Keung Suen, Kwong Chun Lo, Shu Yeun Wu, Wing Wai Wong
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Publication number: 20110292394Abstract: Disclosed are optical sensing devices and methods for detecting samples using the same. The optical sensing device comprises a source unit configured to generate a polychromatic light beam containing p-polarized and s-polarized components; an interferometric unit configured to split the light beam into a probe beam passing a first path and a reference beam passing a second path and to recombine the probe beam output from the first path and the reference beam output from the second path; a sensing unit disposed in the first path to introduce a first SPR effect associated with a target sample to the probe beam; and a detection unit configured to detect target sample characteristics by obtaining an intensity spectrum of the recombined light beam. The introduction of a polychromatic light source in the optical sensing device increases the detection dynamic range and the detection sensitivity.Type: ApplicationFiled: May 23, 2011Publication date: December 1, 2011Applicants: THE CHINESE UNIVERSITY OF HONG KONG, CITY UNIVERSITY OF HONG KONGInventors: Lawrence Chi-man Wu, Siu pang Ng, Ho Pui Ho, Shu Yuen Wu
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Patent number: 7892855Abstract: Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to provide a reference signal; a SPR sensing unit receiving a second part of the light to induce a phase retardation change between the p- and s-polarization components due to SPR associated with a sample; a probe unit receiving the light after SPR to provide a probe signal; and a detection unit connected to the reference unit and the probe unit to detect characteristics of the sample by comparing the reference signal with the probe signal. By using active phase modulation technologies and differential phase measurement, it is possible to fulfill chemical and biological detection.Type: GrantFiled: August 4, 2008Date of Patent: February 22, 2011Assignee: The Chinese University of Hong KongInventors: Ho Pui Ho, Shu Yuen Wu, Chinlon Lin, Siu Kai Kong
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Patent number: 7623246Abstract: Disclosed is an optical sensing device, which comprises a light source emitting a light; a beam splitter; an SPR sensor unit comprising a sensing surface; and a detecting mechanism; and a converting unit converting the first beam and the second beam from the optical device into a two-dimensional interference fringe pattern. From the above-mentioned configuration, an extra phase shift of a detection beam in SPR phase measurement is obtained. The differential measurement approach has shown to achieve a sensitivity figure significantly better than the best result that can be obtained from the prior art in the field of the measurement based on an SPR sensor.Type: GrantFiled: March 11, 2008Date of Patent: November 24, 2009Assignee: The Chinese University of Hong KongInventors: Ho Pui Ho, Chi Lok Wong, Shu Yuen Wu, Wing Cheung Law, Chinlon Lin, Siu Kai Kong
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Publication number: 20090251707Abstract: There is disclosed a phase sensitive surface plasmon resonance sensing apparatus wherein a testing beam may be reflected from a sensing surface at a plurality of angles. There are also disclosed methods for surface plasmon resonance sensing.Type: ApplicationFiled: March 20, 2009Publication date: October 8, 2009Applicant: The Chinese University on Hong KongInventors: Ho Pui Ho, Siu Kai Kong, Yick Keung Suen, Kwong Chun Lo, Shu Yeun Wu, Wing Wai Wong
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Publication number: 20090086210Abstract: Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to provide a reference signal; a SPR sensing unit receiving a second part of the light to induce a phase retardation change between the p- and s-polarization components due to SPR associated with a sample; a probe unit receiving the light after SPR to provide a probe signal; and a detection unit connected to the reference unit and the probe unit to detect characteristics of the sample by comparing the reference signal with the probe signal. By using active phase modulation technologies and differential phase measurement, it is possible to fulfill chemical and biological detection.Type: ApplicationFiled: August 4, 2008Publication date: April 2, 2009Applicant: The Chinese University of Hong KongInventors: Ho Pui Ho, Shu Yuen Wu, Chinlon Lin, Siu Kai Kong
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Publication number: 20080304072Abstract: Disclosed is an optical sensing device, which comprises a light source emitting a light; a beam splitter; an SPR sensor unit comprising a sensing surface; and a detecting mechanism; and a converting unit converting the first beam and the second beam from the optical device into a two-dimensional interference fringe pattern. From the above-mentioned configuration, an extra phase shift of a detection beam in SPR phase measurement is obtained. The differential measurement approach has shown to achieve a sensitivity figure significantly better than the best result that can be obtained from the prior art in the field of the measurement based on an SPR sensor.Type: ApplicationFiled: March 11, 2008Publication date: December 11, 2008Applicant: The Chinese University of Hong KongInventors: Ho Pui Ho, Chi Lok Wong, Shu Yuen Wu, Wing Cheung Law, Chinlon Lin, Sui Kai Kong
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Patent number: 7407817Abstract: Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to provide a reference signal; a SPR sensing unit receiving a second part of the light to induce a phase retardation change between the p- and s-polarization components due to SPR associated with a sample; a probe unit receiving the light after SPR to provide a probe signal; and a detection unit connected to the reference unit and the probe unit to detect characteristics of the sample by comparing the reference signal with the probe signal. By using active phase modulation technologies and differential phase measurement, it is possible to fulfill chemical and biological detection.Type: GrantFiled: January 19, 2006Date of Patent: August 5, 2008Assignee: The Chinese University of Hong KongInventors: Ho Pui Ho, Shu Yuen Wu, Chinlon Lin, Siu Kai Kong
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Patent number: 7365855Abstract: Disclosed is an optical sensing device, which comprises a light source emitting a light; a beam splitter; an SPR sensor unit comprising a sensing surface; and a detecting mechanism; and a converting unit converting the first beam and the second beam from the optical device into a two-dimensional interference fringe pattern. From the above-mentioned configuration, an extra phase shift of a detection beam in SPR phase measurement is obtained. The differential measurement approach has shown to achieve a sensitivity figure significantly better than the best result that can be obtained from the prior art in the field of the measurement based on an SPR sensor.Type: GrantFiled: July 8, 2005Date of Patent: April 29, 2008Assignee: The Chinese University of Hong KongInventors: Ho Pui Ho, Chi Lok Wong, Shu Yuen Wu, Wing Cheung Law, Chinlon Lin, Siu Kai Kong