Abstract: Provided are a biodegradable aliphatic-aromatic polyester copolymer having excellent hydrolysis resistance and high viscosity which has a carboxyl end group (CEG) content of 15 mg KOH/g or less, a ratio (Mz/Mn) of a z-average molecular weight (Mz) to a number average molecular weight (Mn) of 3 to 15, and a melt index (MI) of 5 g/10 min or less as measured under conditions of a temperature of 190° C. and a load of 2.16 kg in accordance with ASTM D 1238. A method of preparing a biodegradable aliphatic-aromatic polyester copolymer is provided, including adding a chain extender and an anti-hydrolysis agent to an aliphatic-aromatic polyester pre-copolymer over time, whereby a significant viscosity rise and improvement of hydrolysis resistance may be implemented simultaneously.

Abstract: A surgery optimizing method performed by a computer is provided. The method includes generating a plurality of genes corresponding to a surgical procedure based on the surgical procedure composed of at least one detailed surgical operation, performing virtual surgery on each of the plurality of genes to evaluate whether surgery is optimized, selecting at least one gene among the plurality of genes based on the evaluation result to apply a genetic algorithm, and applying the genetic algorithm to generate a new gene and deriving an optimal surgical procedure based on the new gene.

Abstract: The present invention is directed to a pharmaceutical compositions improving percutaneous absorbability by absorption assistants, which remarkably increase permeation and dissolution of piroxicam, and penetration enhancers. A further surprising feature of the present invention resides in the fact that absorption assistant which assists penetration enhancer is able to include the active substance excessively in adhesive matrix as solvent of the active substance.