Patents by Inventor Ho-Wah Hui

Ho-Wah Hui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID FORMS COMPRISING 4-AMINO-2-(2,6-DIOXOPIPERIDINE-3-YL)ISOINDOLINE-1,3-DIONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170258778
    Abstract: Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 14, 2017
    Inventors: G. Patrick Stahly, David Jonaitis, Ho-Wah Hui, Kevin J. Klopfer
  • Oral dosage forms of cyclopropanecarboxylic acid {2-[(1S)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl}-amide
    Patent number: 9757355
    Abstract: Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: September 12, 2017
    Assignee: Celgene Corporation
    Inventors: Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
  • FORMULATIONS OF 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE
    Publication number: 20170196847
    Abstract: Provided herein are lyophilized formulations of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. Methods of using the formulations and dosage forms for treating, managing, and/or preventing cancer are also provided herein.
    Type: Application
    Filed: January 6, 2017
    Publication date: July 13, 2017
    Inventors: Ho-Wah Hui, Yu Pu
  • Solid forms comprising 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and a coformer, compositions and methods of use thereof
    Patent number: 9695146
    Abstract: Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: July 4, 2017
    Assignee: Celgene Corporation
    Inventors: G. Patrick Stahly, David Jonaitis, Ho-Wah Hui, Kevin J. Klopfer
  • Nanosuspension of a poorly soluble drug via microfluidization process
    Patent number: 9616019
    Abstract: Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: April 11, 2017
    Assignee: Celgene Corporation
    Inventors: Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
  • ROMIDEPSIN FORMULATIONS AND USES THEREOF
    Publication number: 20170007665
    Abstract: Provided herein are liquid concentrate formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and a citrate buffer. In another embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and an acetate buffer.
    Type: Application
    Filed: September 20, 2016
    Publication date: January 12, 2017
    Inventors: Lianfeng HUANG, Ho-Wah HUI, Vijay NARINGREKAR, Gang YANG
  • ROMIDEPSIN FORMULATIONS AND USES THEREOF
    Publication number: 20170000845
    Abstract: Provided herein are liquid concentrate formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and a citrate buffer. In another embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and an acetate buffer.
    Type: Application
    Filed: September 14, 2016
    Publication date: January 5, 2017
    Inventors: Lianfeng HUANG, Ho-Wah HUI, Vijay NARINGREKAR, Gang YANG
  • Controlled release oral dosage forms of poorly soluble drugs and uses thereof
    Patent number: 9532977
    Abstract: Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: January 3, 2017
    Assignee: Celgene Corporation
    Inventors: Ming J. Chen, Ho-Wah Hui, Xiaole Shen
  • ROMIDEPSIN FORMULATIONS AND USES THEREOF
    Publication number: 20160367625
    Abstract: Provided herein are formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one embodiment, the formulation is a combination of romidepsin and mannitol.
    Type: Application
    Filed: September 6, 2016
    Publication date: December 22, 2016
    Inventors: Lianfeng HUANG, Ho-Wah HUI, Victor PEYKOV, Willard R. FOSS, Vijay NARINGREKAR, Mei LAI
  • Romidepsin formulations and uses thereof
    Patent number: 9468664
    Abstract: Provided herein are liquid concentrate formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and a citrate buffer. In another embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and an acetate buffer.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 18, 2016
    Assignee: Celgene Corporation
    Inventors: Lianfeng Huang, Ho-Wah Hui, Vijay Naringrekar, Gang Yang
  • SOLID FORMS COMPRISING 4-AMINO-I-B-D-RIBOFURANOSYL-1,3,5-TRIAZIN-2 (1H) -ONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20160296546
    Abstract: Provided herein are solid forms comprising (a) 4-amino-1-?-D-ribofuranosyl-1,3,5-triazin-2(1H)-one and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.
    Type: Application
    Filed: March 25, 2014
    Publication date: October 13, 2016
    Inventors: G. Patrick STAHLY, David JONAITIS, Ho-Wah HUI, Kevin J. KLOPFER
  • Romidepsin formulations and uses thereof
    Patent number: 9463215
    Abstract: Provided herein are liquid concentrate formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and a citrate buffer. In another embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and an acetate buffer.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 11, 2016
    Assignee: Celgene Corporation
    Inventors: Lianfeng Huang, Ho-Wah Hui, Vijay Naringrekar, Gang Yang
  • Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-]pyrazin-2(1)-one, a solid form thereof and methods of their use
    Patent number: 9403829
    Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: August 2, 2016
    Assignee: Signal Pharmaceuticals, LLC
    Inventors: Terrence Joseph Connolly, Kevin Joseph Klopfer, William Wei-Hwa Leong, Anil Menon, Amanda Nicole Miklos, Nathan Boersen, Benjamin Cohen, Juan Antonio Gamboa, Ho-Wah Hui, Matthew Michael Kreilein, Thomas Lee, Ying Li, Jean Xu
  • CONTROLLED RELEASE ORAL DOSAGE FORMS OF POORLY SOLUBLE DRUGS AND USES THEREOF
    Publication number: 20160128981
    Abstract: Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders.
    Type: Application
    Filed: November 11, 2015
    Publication date: May 12, 2016
    Inventors: Ming J. CHEN, HO-WAH HUI, XIAOLE SHEN
  • ROMIDEPSIN FORMULATIONS AND USES THEREOF
    Publication number: 20160067304
    Abstract: Provided herein are liquid concentrate formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and a citrate buffer. In another embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and an acetate buffer.
    Type: Application
    Filed: November 17, 2015
    Publication date: March 10, 2016
    Inventors: Lianfeng HUANG, Ho-Wah HUI, Vijay NARINGREKAR, Gang YANG
  • ROMIDEPSIN FORMULATIONS AND USES THEREOF
    Publication number: 20160067303
    Abstract: Provided herein are liquid concentrate formulations of romidepsin. Also provided are methods for producing these formulations and uses thereof. In one embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and a citrate buffer. In another embodiment, the formulation comprises romidepsin, polyethylene glycol, etanol and an acetate buffer.
    Type: Application
    Filed: November 17, 2015
    Publication date: March 10, 2016
    Inventors: Lianfeng HUANG, Ho-Wah HUI, Vijay NARINGREKAR, Gang YANG
  • SOLID FORMS COMPRISING 3-(4-AMINO-1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20160045483
    Abstract: Provided herein are solid forms comprising (a) 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (Lenalidomide) and (b) a coformer. Pharmaceutical compositions comprising the solid forms and methods for treating, preventing and managing various disorders are also disclosed.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 18, 2016
    Applicant: CELGENE CORPORATION
    Inventors: G. Patrick STAHLY, David JONAITIS, Ho-Wah HUI, Kevin J. KLOPFER
  • SOLID FORMS COMPRISING 4-AMINO-2-(2,6-DIOXOPIPERIDINE-3-YL)ISOINDOLINE-1,3-DIONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20160039785
    Abstract: Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions comprising the solid forms (e.g., cocrystals) and methods for treating, preventing and managing various disorders are also disclosed.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 11, 2016
    Inventors: G. Patrick STAHLY, David JONAITIS, Ho-Wah HUI, Kevin J. KLOPFER
  • NANOSUSPENSION OF A POORLY SOLUBLE DRUG VIA MICROFLUIDIZATION PROCESS
    Publication number: 20150265534
    Abstract: Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.
    Type: Application
    Filed: April 1, 2015
    Publication date: September 24, 2015
    Inventors: Ming J. CHEN, Ho-Wah HUI, Thomas LEE, Paul KURTULIK, Sekhar SURAPANENI
  • FORMULATIONS OF CYCLOPROPANECARBOXYLIC ACID -AMIDE
    Publication number: 20150190374
    Abstract: Pharmaceutical compositions and single unit dosage forms of {2-[(IS)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1H-isoindo1-4-yl}-amide, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate thereof, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as cancer or an inflammatory disease.
    Type: Application
    Filed: September 13, 2012
    Publication date: July 9, 2015
    Inventors: Nathan Boersen, Wai Yip Lee, Ho-Wah Hui, Paul Kurtulik