Abstract: Proposed are pharmaceutical compositions and health functional foods containing a Ganoderma lucidum fruiting body extract as an active ingredient for preventing, treating, or ameliorating thrombosis. The extract exhibits strong antithrombotic activity by inhibiting thrombosis-related enzymes and blood coagulation factors, has excellent thermal stability, and exhibits no loss of blood coagulation factor inhibitory effect and thrombogenic enzyme inhibitory effect even in acidic conditions of pH 2 and in plasma. Therefore, the Ganoderma lucidum fruiting body extract is expected to be used for the prevention and treatment of thrombosis, which causes ischemic stroke and hemorrhagic stroke, by improving blood circulation. The Ganoderma lucidum fruiting body extract is very useful in the pharmaceutical and food industries.

Abstract: Disclosed is a method for preventing or treating thrombosis, the method comprising administering a composition containing a hemp (Cannabis sativa L.) leaf or flower extract as an active ingredient. The hemp (Cannabis sativa L.) leaf or flower extract inhibits thrombus formation-related enzymes and coagulation factors and exhibits potent antithrombotic activity through inhibitory activity against platelet aggregation which triggers blood clotting, but with no lytic activity on human erythrocytes. In addition to being stable to heat, the extract does not lose the inhibitory activity against coagulation factors and thrombus formation-related enzymes even in the acidic condition of pH 2 and the plasma environment. Therefore, the extract is expected to find applications in preventing and treating thrombosis such as ischemic stroke and hemorrhagic stroke through blood circulation improvement.

Abstract: An antimicrobial composition containing a wasp extract, and more particularly, a broad-spectrum antimicrobial composition containing, as an active ingredient, an ethyl acetate fraction recovered by sequential organic solvent fraction of an ethanol extract of Vespa velutina nigrithorax or Vespa simillima simillima Smith. The Vespa velutina nigrithorax extract or the V. simillima simillima Smith extract exhibits excellent broad-spectrum antimicrobial activity against gram-positive bacteria, gram-negative bacterial and fungi, and thus may be used for pharmaceutical compositions, health functional foods, cosmetic compositions, animal feed compositions, additives for food, cosmetics or animal feed, various detergents and various cleansers. In addition, the extract has excellent heat stability, and does not lose its activity even under an acidic condition of pH 2.

Abstract: An antibiotic composition containing a wasp extract as an active ingredient, and more particularly, a pharmaceutical composition and a health functional food for preventing, ameliorating or treating diabetes by ?-amylase inhibition and ?-glucosidase inhibition, which contain a wasp extract as an active ingredient. The wasp extract exhibits strong antidiabetic activity by effectively inhibiting amylase, has no human erythrocyte hemolytic activity, has excellent heat stability, and the activity thereof is not lost even under an acidic condition of pH 2 and in plasma. The wasp extract of the present disclosure may be processed into various forms such as extracts, powders, pills or tablets, which can be taken at all times.

Abstract: An antithrombotic composition containing an extract of Vespa velutina nigrithorax as an active ingredient, and more particularly, a pharmaceutical composition and a health functional food for preventing, ameliorating or treating thrombosis by inhibition of blood coagulation and inhibition of platelet aggregation, which contain an ethyl acetate fraction of an extract of Vespa velutina nigrithorax as an active ingredient. The extract exhibits antithrombotic activity by inhibiting platelet aggregation while exhibiting strong anticoagulant activity by inhibiting thrombosis-related enzymes and blood clotting factors. Also, the extract has no human erythrocyte hemolytic activity, has excellent heat stability, and the thrombosis-related enzyme and blood clotting factor inhibitory effects thereof are not lost even under an acidic condition of pH 2 and in plasma.

Abstract: Disclosed is a method for preventing or treating thrombosis, the method comprising administering a composition containing a hemp (Cannabis sativa L.) leaf or flower extract as an active ingredient. The hemp (Cannabis sativa L.) leaf or flower extract inhibits thrombus formation-related enzymes and coagulation factors and exhibits potent antithrombotic activity through inhibitory activity against platelet aggregation which triggers blood clotting, but with no lytic activity on human erythrocytes. In addition to being stable to heat, the extract does not lose the inhibitory activity against coagulation factors and thrombus formation-related enzymes even in the acidic condition of pH 2 and the plasma environment. Therefore, the extract is expected to find applications in preventing and treating thrombosis such as ischemic stroke and hemorrhagic stroke through blood circulation improvement.