Abstract: Compounds degrade target proteins based on chaperone-mediated protein degradation (CMPD) and methods of producing the same, and uses thereof. The present invention provides a target protein degradation compound that includes a first moiety (Chaperone Binding, CB) capable of binding to the chaperone protein or protein components of the chaperone complex, and a second moiety (Target Binding, TB) capable of binding to the target protein or proteins. Such a compound is structured in form of a chaperone binding part (CB)-linker (L)-target binding part (TB) or is a stereoisomer thereof. The compound of the present invention has the effect of inducing degradation of the MET protein based on CMPD technology. Therefore, the compound can be expected to exhibit superior anticancer effects by completely degrading the target protein (MET), thereby overcoming resistance and mutations associated with targeted anticancer drugs.

Abstract: A method and apparatus for authenticating packets in a controller area network (CAN) are disclosed. The method includes transmitting messages using a mixture of message authentication codes (MACs) in a controller area network (CAN). In addition, a first MAC is generated using a first message and the first MAC is divided into a first MAC part and a second MAC part. A second MAC is generated using a second message and the second MAC is divided into a third MAC part and a fourth MAC part. A linear operation is performed between the second MAC part and the third MAC part to generate a first authentication MAC. The first message is transmitted with the first MAC part and the second message is transmitted with the first authentication MAC.

Abstract: A method for processing a SOME/IP stream through interworking with Audio Video Bridging (AVB) in a server includes determining a transmission scheme for the SOME/IP stream through a SOME/IP service discovery procedure and generating an InitialEvent message and transmitting the generated InitialEvent message to a client according to the determined transmission scheme. If the determined transmission scheme is L2-Frame, the SOME/IP stream is transmitted through a layer 2 of AVB. Therefore, a SOME/IP stream, the QoS of which is guaranteed through interworking with AVB, may be provided.

Abstract: A method of transmitting K messages using divided message authentication codes (MACs) in a controller area network (CAN) includes: generating a MAC using a first message and a specific MAC, performing a first operation with respect to j using j-th messages subsequent to the first message and a second MAC part of the generated MAC, performing a second operation with respect to j using a result of the performed first operation and a j-th subblock subsequent to a first MAC subblock among K MAC subblocks obtained by dividing a first MAC part of the generated MAC, transmitting the first message along with the first MAC subblock, and transmitting K-1 j-th messages in an order of j, each of the j-th messages being transmitted along with a j-th result of the performed second operation.

Abstract: A method for providing time synchronization in a node connected to an Audio Video Bridging (AVB) Ethernet communication network includes steps of receiving static announcement messages from adjacent nodes and constituting a static grandmaster table, reselecting a grandmaster with reference to the static grandmaster table when a synchronization message timer expires, and updating the static grandmaster table according to reselection of the grandmaster. The method may rapidly time synchronization in the Audio Video Bridging (AVB) Ethernet communication network and minimize network load.

Abstract: A method for detecting intrusion into an in-vehicle network using an intrusion detection system (IDS) of a vehicle includes: receiving messages of the in-vehicle network in a preset cycle, calculating a current count value per message of the received messages, receiving operation state information of the vehicle when the cycle starts, determining a normal count value per message corresponding to the operation state information, calculating a linearly approximated relative distance function per message using the current count value and the normal count value, and determining whether an intrusion state occurs by comparing the calculated linearly approximated relative distance function per message to a preset threshold value.

Abstract: A method for providing time synchronization in a node connected to an Audio Video Bridging (AVB) Ethernet communication network includes steps of receiving static announcement messages from adjacent nodes and constituting a static grandmaster table, reselecting a grandmaster with reference to the static grandmaster table when a synchronization message timer expires, and updating the static grandmaster table according to reselection of the grandmaster. The method may rapidly time synchronization in the Audio Video Bridging (AVB) Ethernet communication network and minimize network load.

Abstract: A method for processing a SOME/IP stream through interworking with Audio Video Bridging (AVB) in a server includes determining a transmission scheme for the SOME/IP stream through a SOME/IP service discovery procedure and generating an InitialEvent message and transmitting the generated InitialEvent message to a client according to the determined transmission scheme. If the determined transmission scheme is L2-Frame, the SOME/IP stream is transmitted through a layer 2 of AVB. Therefore, a SOME/IP stream, the QoS of which is guaranteed through interworking with AVB, may be provided.

Abstract: A method of transmitting K messages using divided message authentication codes (MACs) in a controller area network (CAN) includes: generating a MAC using a first message and a specific MAC, performing a first operation with respect to j using j-th messages subsequent to the first message and a second MAC part of the generated MAC, performing a second operation with respect to j using a result of the performed first operation and a j-th subblock subsequent to a first MAC subblock among K MAC subblocks obtained by dividing a first MAC part of the generated MAC, transmitting the first message along with the first MAC subblock, and transmitting K-1 j-th messages in an order of j, each of the j-th messages being transmitted along with a j-th result of the performed second operation.

Abstract: A method and apparatus for authenticating packets in a controller area network (CAN) are disclosed. The method includes transmitting messages using a mixture of message authentication codes (MACs) in a controller area network (CAN). In addition, a first MAC is generated using a first message and the first MAC is divided into a first MAC part and a second MAC part. A second MAC is generated using a second message and the second MAC is divided into a third MAC part and a fourth MAC part. A linear operation is performed between the second MAC part and the third MAC part to generate a first authentication MAC. The first message is transmitted with the first MAC part and the second message is transmitted with the first authentication MAC.

Abstract: A method for providing a black box service for vehicle diagnosis and an apparatus and system therefor are disclosed herein. A method for providing a black box service for vehicle diagnosis in an in-vehicle apparatus connected to a network includes confirming whether or not a time synchronization message including a black box address is received, updating status information in the apparatus, when the time synchronization message is received as a result of confirmation, and transmitting a status information message including the updated status information to the black box address set as a destination address. Therefore, a more stable black box service for vehicle diagnosis is provided.

Abstract: Disclosed herein is an anti-skid boot, having a crampon, provided with both an outer sole and a boot body. The anti-skid boot includes a crampon which is provided around an outer surface of a front part of the outer sole. The crampon includes a plurality of triangular protrusions, a plurality of oblique slots and a locking notch. The anti-skid boot further includes a plate spring which is provided between the crampon and the outer sole. The anti-skid boot further includes a plurality of support pins which is fastened to the outer surface of the outer sole after passing through the plurality of oblique slots, and a locking hook which is rotatably coupled to a predetermined position of the outer surface of the outer sole adjacent to each of the opposite ends of the crampon. In the present invention, the crampon is normally located around the outer sole of the anti-skid boot to allow a user to walk on level ground, and the crampon is protruded downwards from the outer sole by only a simple manipulation at need.