Abstract: The present disclosure relates to a serum exosomal SF3B4 marker composition for diagnosing early stage hepatocellular carcinoma for noninvasive in vitro diagnosis, wherein, by analyzing an expression level of SF3B4 in plasma proteins as well as expression of SF3B4 in exosomes present in sera of hepatocellular carcinoma patients, the possibility as the most suitable liquid biopsy marker was identified, and a new noninvasive biomarker with high diagnostic accuracy in early stage hepatocellular carcinoma for which no reliable biomarker exists at this present was discovered. As such, by using exosomes to identify cancer cell genomes and proteomes without biopsy, the exosomes are highly applicable in the future as a diagnostic biomarker that is useful in a disease group with a high risk in the biopsy such as hepatocellular carcinoma.

Abstract: The rubber composition for tire tread and a tire includes 100 parts by weight of a raw material rubber that includes 20 parts by 80 parts by weight of a first solution polymerized styrene-butadiene rubber (SBR1) having a styrene content of 15% to 25% by weight and a vinyl content in the butadiene of 60% to 65% by weight and produced by a batch method; and 60 parts to 90 parts by weight of a silica having a specific surface area measured by nitrogen adsorption of 155 m2/g to 185 m2/g and a CTAB value of 150 m2/g to 170 m2/g.

Abstract: Provided are a rubber composition for tire tread including 100 parts by weight of a raw material rubber that includes 20 parts by 80 parts by weight of a first solution polymerized styrene-butadiene rubber (SBR1) having a styrene content of 15% to 25% by weight and a vinyl content in the butadiene of 60% to 65% by weight and produced by a batch method; and 60 parts to 90 parts by weight of a silica having a specific surface area measured by nitrogen adsorption of 155 m2/g to 185 m2/g and a CTAB value of 150 m2/g to 170 m2/g, and a tire producing using the rubber composition. The rubber composition for tire tread has excellent processability in an unvulcanized state, and can improve all of the braking performance on wet road surfaces, the braking performance on icy road surfaces, and the low fuel consumption performance.