Patents by Inventor Hoa N. Nguyen

Hoa N. Nguyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing tetracyclic heterocycle compounds
    Patent number: 9725464
    Abstract: The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: August 8, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Ian Mangion, Cheng-yi Chen, Ingyu Jeon, Yonggang Chen, Hongmei Li, Hoa N. Nguyen, Peter E. Maligres, Artis Klapars, Ilia Zavialov, Nobuyoshi Yasuda
  • PROCESS FOR PREPARING TETRACYCLIC HETEROCYCLE COMPOUNDS
    Publication number: 20160257698
    Abstract: The present invention is directed to a process for preparing Tetracyclic Heterocycle Compounds of formula (I): which are useful as HCV NS5A inhibitors. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).
    Type: Application
    Filed: October 24, 2014
    Publication date: September 8, 2016
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Ian Mangion, Cheng-yi Chen, Ingyu Jeon, Yonggang Chen, Hongmei Li, Hoa N. Nguyen, Peter E. Maligres, Artis Klapars, Ilia Zavialov, Nobuyoshi Yasuda
  • Exo- and diastereo-selective synthesis of himbacine analogs
    Patent number: 8618314
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: December 31, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: George G. Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank X. Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Illia Zavialov, Hoa N. Nguyen, Ngiap Kie Lim
  • EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS
    Publication number: 20120296093
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: July 31, 2012
    Publication date: November 22, 2012
    Inventors: George Wu, Anantha R. SUDHAKAR, Tao WANG, Ji XIE, Frank Xing CHEN, Marc POIRIER, Mingsheng HUANG, Vijay SABESAN, Daw-long KWOK, Jian CUI, Xiaojing YANG, Tiruvettipuram K. THIRUVENGADAM, Jing LIAO, Ilia A. Zavialov, Hoa N. NGUYEN, Ngiap Kie LIM
  • Exo- and diastereo- selective synthesis of himbacine analogs
    Patent number: 8258319
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 4, 2012
    Assignee: Schering Corporation
    Inventors: George G. Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank X. Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia Zavialov, Hoa N. Nguyen, Ngiap Kie. Lim
  • EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS
    Publication number: 20110251392
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: June 24, 2011
    Publication date: October 13, 2011
    Inventors: George Wu, Anantha R. Sudhakar, Mingsheng Huang, Tao Wang, Vijay Sabesan, Ji Xie, Frank Xing Chen, Marc Poirier, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia A. Zavialov, Hoa N. Nguyen, Ngiap Kie. Lim
  • Exo- and diastereo-selective syntheses of himbacine analogs
    Patent number: 7989653
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: August 2, 2011
    Assignee: Schering Corporation
    Inventors: George G. Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank X. Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-Iong Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia Zavialov, Hoa N. Nguyen, Ngiap Kie Lim
  • Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof
    Patent number: 7786301
    Abstract: A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to synthesize Compound 7, and a coupling reaction to produce Compound 9.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: August 31, 2010
    Assignee: Schering Corporation
    Inventors: Vilas A. Dahanukar, Hoa N. Nguyen, Cecilia A. Orr, Fucheng Zhang, Ilia Zavialov
  • Synthesis of CCR5 receptor antagonists
    Patent number: 7728135
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: June 1, 2010
    Assignee: Schering Corporation
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecelia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS
    Publication number: 20100036125
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 11, 2010
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS
    Publication number: 20090281321
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: July 17, 2009
    Publication date: November 12, 2009
    Inventors: George Wu, Anantha R. Sudhakar, Tao Wang, Ji Xie, Frank Xing Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia A. Zavialov, Hoa N. Nguyen, Ngiap Kie Lim
  • Exo- and diastereo- selective syntheses of himbacine analogs
    Patent number: 7605275
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: October 20, 2009
    Assignee: Schering Corporation
    Inventors: Frank Xing Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, George Wu, Anantha R. Sudhakar, Tao Wang, Ji Xie, Jing Liao, Ilia A. Zavialov, Hoa N. Nguyen, Ngiap Kie Lim, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam
  • Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl
    Patent number: 7326795
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: February 5, 2008
    Assignee: Schering Corporation
    Inventors: Anantha Sudhakar, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Orr, Hoa N. Nguyen, Juergen Weber, Ingyu Jeon, Minzhang Chen, Michael D. Green, George S. Wong, Jeonghan Park, Tetsuo Iwama
  • Xanthine phosphodiesterase V inhibitor polymorphs
    Patent number: 7192962
    Abstract: Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R) -(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit x-ray powder diffraction profiles substantially the same as those shown in FIGS. 5 and 6, respectively, and which exhibit differential scanning calorimtery profiles substantially the same as those shown in FIGS. 2 and 4, respectively, and are represented by the formula: Pharmaceutical compositions comprising the polymorph Form 1 or 2 of Compound 13 and at least one excipient or carrier, and methods of using the polymorph Form 1 or 2 of Compound 13 to treat a variety of physiological disorders, such as erectile dysfunction.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: March 20, 2007
    Assignee: Schering Corporation
    Inventors: Vilas H. Dahanukar, Hoa N. Nguyen, Cecilia A. Orr, Funcheng Zhang, Ilia A. Zavialov, Kevin Klopfer, Jeffrey M. Skell, Albert W. Buchholz, Jr., Craig D. Boyle
  • Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof
    Patent number: 7074923
    Abstract: A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: July 11, 2006
    Assignee: Schering Corporation
    Inventors: Vilas A. Dahanukar, Hoa N. Nguyen, Cecilia A. Orr, Fucheng Zhang, Ilia A. Zavialov
  • Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof
    Publication number: 20030232987
    Abstract: A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to synthesize Compound 7, and a coupling reaction to produce Compound 9.
    Type: Application
    Filed: May 30, 2003
    Publication date: December 18, 2003
    Applicant: SCHERING CORPORATION
    Inventors: Vilas A. Dahanukar, Hoa N. Nguyen, Cecilia A. Orr, Fucheng Zhang, Ilia A. Zavialov
  • Xanthine phosphodiesterase V inhibitor polymorphs
    Publication number: 20030232845
    Abstract: Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R)-(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit x-ray powder diffraction profiles substantially the same as those shown in FIGS. 5 and 6, respectively, and which exhibit differential scanning calorimtery profiles substantially the same as those shown in FIGS.
    Type: Application
    Filed: May 30, 2003
    Publication date: December 18, 2003
    Applicant: SCHERING CORPORATION
    Inventors: Vilas H. Dahanukar, Hoa N. Nguyen, Cecilia A. Orr, Funcheng Zhang, Ilia A. Zavialov, Kevin Klopfer, Jeffrey M. Skell, Albert W. Buchholz, Craig D. Boyle