Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh. a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.

Abstract: Devices, systems, and methods for removing obstructions from body lumens are disclosed herein. In some embodiments, a system for removing a thrombus includes an interventional element configured to be disposed proximate to or adjacent to a thrombus within a blood vessel. The system can include a signal generator in electrical communication with the interventional element. The signal generator can be configured to deliver an electrical signal to the interventional element. The electrical signal can include a waveform having a positive phase having a peak positive current and a first duration, and a negative phase having a peak negative current and a second duration. A magnitude of the peak positive current can be greater than a magnitude of the peak negative current, and the first duration can be greater than the second duration.

Abstract: A flow combiner is provided for a gas turbine engine. The flow combiner includes an outlet duct, a compressor bleed inlet duct coupled to the outlet duct, and a ventilation inlet duct coupled to the outlet duct. The compressor bleed inlet duct is configured to receive a bleed flow from a compressor of the gas turbine engine. The ventilation inlet duct is configured to receive a ventilation flow from an enclosure surrounding the gas turbine engine. The bleed flow and the ventilation flow are combined as an outlet flow through the outlet duct.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible conduit having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the conduit distal portion. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: Treatment of aneurysms can be improved by use of a treatment system including a conduit have a distal portion, a coupler slidably coupled to the distal portion, an occlusive member coupled to the coupler, and a securing member coupled to the conduit proximal to the coupler. The securing member can include a distal end portion that is removably coupled to the coupler. In some embodiments, the securing member can have a shape and/or be treated such that the securing member self-expands to decouple itself from the coupler during deployment of the occlusive member. In some embodiments, movement of the conduit relative to the coupler causes the securing member to decouple from the coupler.

Abstract: A current generator for a medical treatment system is disclosed herein. In one example, the medical treatment system can include a cable and a current generator. The cable can include a distal portion that couples to a medical device and a proximal portion. The proximal portion of the cable can include a first and second conductor, with each conductor having an exposed contact region. The current generator can releasably couple to the cable to deliver an electrical signal. The current generator can include an inner chamber that can receive at least a portion of the cable. The current generator can also include first and second electrical connectors, which can electrically connect to the conductors. The current generator can also include a cable guide that can assist with position the cable within the inner chamber and a cable lock that can lock a part of the cable in position.

Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh, a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.

Abstract: A medical treatment device is disclosed herein. In one example, the medical treatment device includes a core assembly which has a first conduct and a second conductor, the second conductor being formed from a first conductive material. An insulative material can surround the second conductor and define one or more uninsulated portions. A second conductive material can surround the first conductive material along at least a portion of the one or more uninsulated portions and can have a higher electrical conductivity than the first conductive material. The medical treatment device can include an interventional element formed from a third conductive material that electrical couples to the first conductor. A fourth conductive material can be disposed over the third conductive material and have a higher electrical conductivity than the third conductive material.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible conduit having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the conduit distal portion. The conduit has a lumen configured to pass an embolic element therethrough.

Abstract: A medical treatment device is disclosed herein. In one example, the medical treatment device includes a core assembly which has a first conduct and a second conductor. An insulative material can surround the second conductor and define an electrode portion of the second conductor that is uncovered by the insulative material. The medical treatment device can include an interventional element that electrical couples to the first conductor. The electrode portion of the second conductor can be disposed radially adjacent to or distal of the interventional element.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply. The interventional element may be configured to evert over and around the clot material while current is delivered to the interventional element.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to a medical device. The device can include an elongate core member having a distal portion configured to be intravascularly positioned at a treatment site within a blood vessel lumen, and an interventional element connected to the distal portion of the elongate core member. The interventional element includes a body that is expandable from a first configuration to a second configuration and an electrically conductive radiopaque marker coupled to the body. An electrically conductive lead has a distal portion electrically coupled to the radiopaque marker and a proximal portion configured to be electrically coupled to a current source.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can an interventional element configured to be delivered to a treatment site and to be electrically coupled to an extracorporeal power supply. The interventional element can be surface treated (e.g., via electrochemical anodization) to achieve a desired electrical conductivity gradient over the surface of the interventional element. The electrical conductivity gradient can result in a more desirable surface charge distribution upon delivery of electrical current to the interventional element.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a manipulation member configured to be electrically coupled to an extracorporeal power supply and an interventional element configured to be mechanically and electrically coupled to the manipulation member via a joining element. A locking element can be positioned within the joining element to facilitate securing the interventional element to the joining element. In some embodiments, the system includes a control member configured to be coupled to a second terminal of the extracorporeal power supply and positioned within a lumen of the locking element.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

Abstract: A system includes an acoustic monitoring, analysis, and diagnostic system having a processor. The processor is configured to receive NF noise signals from a near field (NF) microphone array, the NF microphone array measures noises from a power generation system in a NF. The processor is configured to receive FF noise signals from a far field (FF) microphone array, the FF microphone array measures noises from a power generation system in a FF. The processor is configured to derive NF and FF noise measurements based on the signals and to synchronize the NF and FF noise measurements to create synchronized NF and FF noise data. The processor is configured to analyze the synchronized NF and FF noise data to create a NF and an FF noise signature. The processor is configured to diagnose root causes of noises generated from the power generation system and to report the root causes.

Abstract: Vasculature models and associated systems and methods are disclosed herein. In some embodiments, the model comprises a tube including a lumen extending therethrough, a synthetic thrombus including a magnetic component, and a magnetized member. The thrombus is sized to be positioned within the lumen, and the magnetized member is positioned peripheral to the thrombus such that a radially outward force is exerted on the thrombus via the magnetized member. The tube may be part of a network of tubes that generally resemble human neurovasculature.

Abstract: Retrieval of material from vessel lumens can be improved by use of a distal element comprising an expandable mesh. a treatment device includes an elongated member having a proximal portion and a distal portion configured to be positioned within a blood vessel at a treatment site at or near a thrombus. A distal element comprising an expandable mesh is coupled to the distal portion of the elongated member via a connection assembly. In an expanded state, at least a portion of the mesh is configured to be in apposition with the blood vessel wall at the treatment site to anchor or stabilize the elongated member with respect to the blood vessel. The distal element can be electrically coupled to an extracorporeal current generator.