Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SNCA gene, particularly in a CNS tissue, as well as methods of inhibiting expression of a SNCA gene and methods of treating subjects having a SNCA-associated neurodegenerative disease or disorder, e.g., Parkinson's Disease (PD), multiple system atrophy (MSA), Lewy body dementia (LBD), among other synucleinopathies, using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SNCA gene, particularly in a CNS tissue, as well as methods of inhibiting expression of a SNCA gene and methods of treating subjects having a SNCA-associated neurodegenerative disease or disorder, e.g., Parkinson's Disease (PD), multiple system atrophy (MSA), Lewy body dementia (LBD), among other synucleinopathies, using such dsRNAi agents and compositions.

Abstract: The disclosure relates to use of double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an amyloid precursor protein (APP) gene, including methods of inhibiting expression of an APP gene and methods of treating subjects having a disease or disorder characterized by enlarged endosomes, e.g., Alzheimer's disease (AD) and Down syndrome (DS), particularly occurrences of such neurodegenerative diseases associated with one or more mutations in presenilin 1 (PSEN1), using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a leucine-rich repeat kinase 2 (LRRK2) gene, as well as methods of inhibiting expression of a LRRK2 gene and methods of treating subjects having a LRRK2-associated disease or disorder, e.g., Parkinson's disease, using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a human chromosome 9 open reading frame 72 (C9orf72) gene, as well as methods of inhibiting expression of a C9orf72 gene and methods of treating subjects having a C9orf72-associated disease or disorder, e.g., C9orf72 amyotrophic lateral sclerosis, frontotemporal dementia or Huntington-Like Syndrome Due To C9orf72 Expansions, using such dsRNAi agents and compositions.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a Stearoyl-CoA Desaturase 5 (SCD5) gene, as well as methods of inhibiting expression of an SCD5 gene and methods of treating subjects having an SCD5-associated disease or disorder, e.g., Parkinson's disease, using such dsRNAi agents and compositions.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SNCA gene, as well as methods of inhibiting expression of a SNCA gene and methods of treating subjects having a SNCA-associated neurodegenerative disease or disorder, e.g., Parkinson's Disease (PD), multiple system atrophy, Lewy body dementia (LBD), among other synucleinopathies, using such dsRNAi agents and compositions.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a leucine-rich repeat kinase 2 (LRRK2) gene, as well as methods of inhibiting expression of a LRRK2 gene and methods of treating subjects having a LRRK2-associated disease or disorder, e.g., Parkinson's disease, using such dsRNAi agents and compositions.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: An improved chimney starter having a cylindrical housing having an outer wall and inner wall defining a chamber, the chamber configured to hold charcoal. A series of spiral heat exchange chambers contained within the cylindrical housing and an air intake port provided on a portion of the cylindrical housing, wherein the air intake port is connected to the series of spiral heat exchange chambers. A base configured to retain a fire starter configured to ignite and burn the charcoal. Advantageously, a fan blower is configured to be positioned in the air intake port such that blown air is configured to be directed through the series of spiral heat exchange chambers, wherein the directed air accelerates the burning of the charcoal.

Abstract: A chimney starter booster has an air intake port and an air output port connected by internal ducting in the booster's housing. The air intake port is configured to accept a wireless fan blower. The fan blower supplies directed air through the ducting and out the air output port containing an air deflecting nozzle. A standard chimney starter sits on a top portion of the booster's housing, such that the directed air enters the bottom of the chimney starter to accelerate the burning of the charcoal.

Abstract: A chimney starter booster has an air intake port and an air output port connected by internal ducting in the booster's housing. The air intake port is configured to accept a wireless fan blower. The fan blower supplies directed air through the ducting and out the air output port containing an air deflecting nozzle. A standard chimney starter sits on a top portion of the booster's housing, such that the directed air enters the bottom of the chimney starter to accelerate the burning of the charcoal.

Abstract: An improved chimney starter having a cylindrical housing having an outer wall and inner wall defining a chamber, the chamber configured to hold charcoal. A series of spiral heat exchange chambers contained within the cylindrical housing and an air intake port provided on a portion of the cylindrical housing, wherein the air intake port is connected to the series of spiral heat exchange chambers. A base configured to retain a fire starter configured to ignite and burn the charcoal. Advantageously, a fan blower is configured to be positioned in the air intake port such that blown air is configured to be directed through the series of spiral heat exchange chambers, wherein the directed air accelerates the burning of the charcoal.

Abstract: A fastening device, a fastening system comprising a fastening device and corresponding slots/routs are described. There is a fastening device having at least two sides. In another embodiment the fastening device has three sides. Two of the three sides are about ninety degrees to each other and each of the two sides have a fastener located on its outer surface. There is one corresponding slot for each fastener. Each corresponding slot is on the surface of two separate substrates and located approximately ten millimeters away from an outermost edge of the substrate. The fastener secures with the corresponding slot, consequently joining the two substrates at approximately ninety degrees.