Abstract: Multi-depot vehicle scheduling in a transportation system may include retrieving vehicle data associated with a set of vehicles and trip data associated with a set of trips, constructing an initial network graph that includes: a respective node for each of the set of trips and each of the set of garages, and a respective edge between each pair of nodes that satisfies schedule constraints related to trip parameters indicated in the trip data, partitioning the initial network graph into a plurality of partitions, that each include respective portions of the initial network graph corresponding to a subsets of the set of vehicles the set of trips, processing each partition of the plurality of partitions separately from other partitions, where processing each partition may comprise, for a given vehicle of the partition, generating a transportation plan that includes a sequence of trips satisfying plan constraints and optimizing an objective function.