Patents by Inventor Hodaka Makino

Hodaka Makino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11946034
    Abstract: A sterile sampling apparatus includes a first to seventh flow paths, a sampling section, a first and second pumps, and a first to sixth opening/closing mechanism. The sampling section is disposed in the seventh flow path. The first pump is disposed in the sixth flow path. The second pump is disposed in the seventh flow path. The second flow path includes a first opening/closing mechanism. The third flow path includes a second opening/closing mechanism. The fourth flow path includes a third opening/closing mechanism. The first flow path includes a fourth opening/closing mechanism. The sixth flow path includes a fifth opening/closing mechanism. The seventh flow path includes a sixth opening/closing mechanism. The rate of the second pump is higher than that of the first pump.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: April 2, 2024
    Assignee: Nihon Kohden Corporation
    Inventors: Hodaka Makino, Hirotsugu Kubo
  • Publication number: 20230035766
    Abstract: The presently disclosed subject matter provides a cell culture evaluation system including a measurement unit, a first storage unit, a second storage unit, an evaluation unit and an output unit, wherein: the measurement unit includes a sensor that acquires evaluation target data about motion or a state of a culture tool; the first storage unit stores the evaluation target data; the second storage unit stores reference data; the evaluation unit compares the evaluation target data with the reference data so as to evaluate an execution state of a cell culture process; and the output unit outputs an evaluation result created by the evaluation unit.
    Type: Application
    Filed: December 21, 2020
    Publication date: February 2, 2023
    Inventors: Hodaka Makino, Hirotsugu Kubo, Masahiro Kinooka
  • Patent number: 11505774
    Abstract: A sample storage apparatus includes: a lid member; a sample storage container; first and second fluid sucking sections; first and second fluid discharging sections; first to fourth flow paths; and a first fluid identification sensor. The first flow path is connected to the first fluid sucking section, the second flow path is connected to the second fluid sucking section, the third flow path is connected to the first fluid discharging section, and the fourth flow path is connected to the second fluid discharging section. The first fluid identification sensor for identifying a fluid is disposed in the first flow path.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: November 22, 2022
    Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka Makino, Hirotsugu Kubo, Tetsuya Ogawa, Masahiro Kinooka
  • Patent number: 11318456
    Abstract: An aseptic sampling apparatus includes an isolator, a liquid delivery port that is disposed in the isolator, a sampling section that is disposed inside the isolator, a first flow path that communicates with a discharge flow path of the sampling section, and that connects an inside and outside of the isolator to each other through the liquid delivery port, a fluid supplying unit that supplies a fluid to the sampling section, a gas supplying unit that communicates with the fluid supplying unit, and a seal member that prevents the fluid supplied from fluid supplying unit to the discharge flow path from leaking.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: May 3, 2022
    Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka Makino, Hirotsugu Kubo, Tetsuya Ogawa, Masahiro Kinooka
  • Patent number: 11320344
    Abstract: An aseptic sampling flow path kit to be applied to an isolator having a liquid delivery port includes a sampling section, a first flow path that communicates with the sampling section, and that connects an inside of the isolator to an outside of the isolator through the liquid delivery port, and at least one one-way valve which is disposed in the first flow path, and that limits flow of fluid in the first flow path to a direction from the sampling section toward the liquid delivery port. In the kit, at least a part of the first flow path is a germicidal flow path to which a germicidal unit is applicable.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: May 3, 2022
    Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka Makino, Hirotsugu Kubo, Masahiro Kinooka
  • Patent number: 11312935
    Abstract: An object of the present disclosure is to provide a cell culture system, a cell culture environment evaluation device, and a program, capable of performing evaluation of a culture environment without causing an adverse effect on cell culture. An isolator is provided with a culture environment for housing a cell culture vessel having a culture solution containing cells to be cultured placed therein. A sensing unit measures the state of the culture environment and transmits the measurement result of the culture environment to the outside of the isolator. A control device receives the measurement result and performs evaluation in the culture environment based on the measurement result.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: April 26, 2022
    Assignee: Nihon Kohden Corporation
    Inventors: Hodaka Makino, Wataru Matsuzawa
  • Patent number: 11313851
    Abstract: A device for measuring a tension of a cell structure containing muscle cells includes a first and a second gel adaptor holder. The first gel adaptor holder includes a frame member and a first gel holding portion which is disposed protrudingly from a part of an inner surface of the frame member for fixing one end of a gel. The second gel adaptor holder includes a second gel holding portion that fixes another end of the gel, and connecting members connected with the second gel holding portion. A kit including the device, a substrate and a gel forming cover. The substrate includes a pair of gel shaping convex parts fitted along the inner surface of the frame member. The gel forming cover includes a surface parallel to a gel contacting surface of the substrate, in order to form an upper surface of the gel.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: April 26, 2022
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Hirotsugu Kubo, Takahiro Shioyama, Yuki Kagawa, Yuto Hinata, Hodaka Makino
  • Publication number: 20210285935
    Abstract: A tension measuring device include a first container in which a cell structure is disposed and which is charged with a culture medium so that the cell structure is immersed therein; a second container in which a medical agent to be given to the inside of the first container is injected; a first tube which links the first container and the second container liquidtightly; and a pump which is disposed over the first tube and causes liquid to flow into the first container from the second container.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 16, 2021
    Applicant: NIHON KOHDEN CORPORATION
    Inventors: Hodaka MAKINO, Tetsuya OGAWA
  • Publication number: 20210024869
    Abstract: A sterile sampling apparatus includes a first to seventh flow paths, a sampling section, a first and second pumps, and a first to sixth opening/closing mechanism. The sampling section is disposed in the seventh flow path. The first pump is disposed in the sixth flow path. The second pump is disposed in the seventh flow path. The second flow path includes a first opening/closing mechanism. The third flow path includes a second opening/closing mechanism. The fourth flow path includes a third opening/closing mechanism. The first flow path includes a fourth opening/closing mechanism. The sixth flow path includes a fifth opening/closing mechanism. The seventh flow path includes a sixth opening/closing mechanism. The rate of the second pump is higher than that of the first pump.
    Type: Application
    Filed: July 20, 2020
    Publication date: January 28, 2021
    Inventors: Hodaka MAKINO, Hirotsugu KUBO
  • Publication number: 20200278342
    Abstract: A device for measuring a tension of a cell structure containing muscle cells includes a first and a second gel adaptor holder. The first gel adaptor holder includes a frame member and a first gel holding portion which is disposed protrudingly from a part of an inner surface of the frame member for fixing one end of a gel. The second gel adaptor holder includes a second gel holding portion that fixes another end of the gel, and connecting members connected with the second gel holding portion. A kit including the device, a substrate and a gel forming cover. The substrate includes a pair of gel shaping convex parts fitted along the inner surface of the frame member. The gel forming cover includes a surface parallel to a gel contacting surface of the substrate, in order to form an upper surface of the gel.
    Type: Application
    Filed: February 27, 2020
    Publication date: September 3, 2020
    Applicant: NIHON KOHDEN CORPORATION
    Inventors: Hirotsugu Kubo, Takahiro Shioyama, Yuki Kagawa, Yuto Hinata, Hodaka Makino
  • Publication number: 20200123489
    Abstract: A sample storage apparatus includes: a lid member; a sample storage container; first and second fluid sucking sections; first and second fluid discharging sections; first to fourth flow paths; and a first fluid identification sensor. The first flow path is connected to the first fluid sucking section, the second flow path is connected to the second fluid sucking section, the third flow path is connected to the first fluid discharging section, and the fourth flow path is connected to the second fluid discharging section. The first fluid identification sensor for identifying a fluid is disposed in the first flow path.
    Type: Application
    Filed: October 22, 2019
    Publication date: April 23, 2020
    Applicants: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka MAKINO, Hirotsugu KUBO, Tetsuya OGAWA, Masahiro KINOOKA
  • Publication number: 20190250073
    Abstract: An aseptic sampling flow path kit to be applied to an isolator having a liquid delivery port includes a sampling section, a first flow path that communicates with the sampling section, and that connects an inside of the isolator to an outside of the isolator through the liquid delivery port, and at least one one-way valve which is disposed in the first flow path, and that limits flow of fluid in the first flow path to a direction from the sampling section toward the liquid delivery port. In the kit, at least a part of the first flow path is a germicidal flow path to which a germicidal unit is applicable.
    Type: Application
    Filed: January 2, 2019
    Publication date: August 15, 2019
    Applicants: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka MAKINO, Hirotsugu KUBO, Masahiro KINOOKA
  • Publication number: 20190247842
    Abstract: An aseptic sampling apparatus includes an isolator, a liquid delivery port that is disposed in the isolator, a sampling section that is disposed inside the isolator, a first flow path that communicates with a discharge flow path of the sampling section, and that connects an inside and outside of the isolator to each other through the liquid delivery port, a fluid supplying unit that supplies a fluid to the sampling section, a gas supplying unit that communicates with the fluid supplying unit, and a seal member that prevents the fluid supplied from fluid supplying unit to the discharge flow path from leaking.
    Type: Application
    Filed: January 3, 2019
    Publication date: August 15, 2019
    Applicants: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka MAKINO, Hirotsugu KUBO, Tetsuya OGAWA, Masahiro KINOOKA
  • Publication number: 20180371396
    Abstract: An object of the present disclosure is to provide a cell culture system, a cell culture environment evaluation device, and a program, capable of performing evaluation of a culture environment without causing an adverse effect on cell culture. An isolator is provided with a culture environment for housing a cell culture vessel having a culture solution containing cells to be cultured placed therein. A sensing unit measures the state of the culture environment and transmits the measurement result of the culture environment to the outside of the isolator. A control device receives the measurement result and performs evaluation in the culture environment based on the measurement result.
    Type: Application
    Filed: December 26, 2017
    Publication date: December 27, 2018
    Applicant: NIHON KOHDEN CORPORATION
    Inventors: Hodaka Makino, Wataru Matsuzawa