Abstract: A computer-implemented method of modelling a root-mean-square stress in a structure induced by a random load. The method comprises determining a modal correction factor based on data representing the eigensolution for the structure in free vibration. The modal correction factor characterizes the proportion of the random load, which is attributable to the root-mean-square response of the structure. Once the modal correction factor has been calculated, it is applied to data representing a stress in the structure due to a forced vibration to thereby determine the root-mean-square stress induced by the random load.

Abstract: The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal-metal interactions, ? . . . ? interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, using a composition comprising a charged d8 or d10 metal complex.

Abstract: A computer-implemented method of modelling a root-mean-square stress in a structure induced by a random load. The method comprises determining a modal correction factor based on data representing the eigensolution for the structure in free vibration. The modal correction factor characterises the proportion of the random load, which is attributable to the root-mean-square response of the structure. Once the modal correction factor has been calculated, it is applied to data representing a stress in the structure due to a forced vibration to thereby determine the root-mean-square stress induced by the random load.

Abstract: The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal . . . metal interactions, ? . . . ? interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, polyaspartate, polyglutamate, using a composition comprising a charged d8 or d10 metal complex.

Abstract: The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal-metal interactions, ? . . . ? interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, using a composition comprising a charged d8 or d10 metal complex.