Abstract: Disclosed herein are methods, and related bioreactors, for manufacturing plant messenger packs (PMPs), which can be formulated for use in a variety of agricultural and therapeutic methods.

Abstract: The computer system applies machine learning techniques to train a computational model using data representing researched items and their known properties. The computer system applies the trained computational model to data representing the potential candidate items to predict whether such items have such properties. The trained computational model outputs one or more predictions about whether the potential candidate items are likely to have a property from among the plurality of types of properties that the computational model is trained to predict. The computer system allows multiple machine learning experiments to be defined, and then allows predictions from those multiple machine learning experiments to be queried, including accessing aggregate statistics for those predictions. In some implementations, a machine learning experiment can specify a computational model that is an ensemble of multiple models.

Abstract: Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.

Abstract: Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.

Abstract: The invention provides isolated achromosomal dynamic active systems (ADAS), including ADAS comprising secretion systems. These ADAS provided by the invention can be obtained by a variety of means. Various associated methods of making and using these ADAS are provided.

Abstract: Anti-viral compounds and methods of using antiviral compounds are described. The compounds can be used in methods of reducing infection rate of a virus and in methods of treating a viral infection in a subject in need thereof. The virus can be a coronavirus, such as SARS-CoV-2.

Abstract: The present disclosure relates to therapeutic agents and combinations thereof (e.g., pharmaceutical compositions) for the treatment of a viral infection in a subject, tissue or cell.

Abstract: Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.

Abstract: Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.

Abstract: Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.

Abstract: The invention provides isolated achromosomal dynamic active systems (ADAS), including highly active ADAS. These ADAS provided by the invention can be obtained by a variety of means. Various associated methods of making and using these ADAS are provided.

Abstract: Disclosed herein are plant-modifying compositions including a plurality of plant messenger packs (PMPs) (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), wherein the PMPs include a plant-modifying agent, and wherein the plant-modifying agent comprising the heterologous RNA. The compositions herein are useful in methods for modifying plants such as to increase plant fitness, wherein the increase in plant fitness comprising an increase in development, growth, yield, resistance to abiotic stressors, or resistance to biotic stressors.

Abstract: Disclosed herein are pathogen control compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are useful in methods for treating or preventing an infection in an animal and/or decreasing the fitness of pathogens (e.g., animal pathogens), or vectors thereof.

Abstract: Disclosed herein are pest control, e.g., biopesticide or biorepellent, compositions including a plurality of plant messenger packs (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof) that are useful in methods for decreasing the fitness of pests (e.g., agriculture pests) and/or increasing the fitness of a plant.

Abstract: Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.

Abstract: Disclosed herein are methods, and related bioreactors, for manufacturing plant messenger packs (PMPs), which can be formulated for use in a variety of agricultural and therapeutic methods.