Patents by Inventor Holger Bindernagel

Holger Bindernagel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of making onapristone intermediates
    Patent number: 10308676
    Abstract: Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: June 4, 2019
    Assignee: CONTEXT BIOPHARMA INC.
    Inventors: Ulf Tilstam, Stefan Proniuk, Holger Bindernagel, Silvia Werner, Holger Rauter
  • Purification of epidaunorubicin
    Patent number: 10081652
    Abstract: A method for purifying epidaunorubicin is provided. The purification method involves the removal of the impurity epi-feudomycin, which is formed as a by-product in the biotechnological production of epidaunorubicin.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: September 25, 2018
    Assignee: medac Gesellschaft für klinische Spezialpräparate mbH
    Inventors: Holger Bindernagel, Tero Kunnari
  • METHODS OF MAKING ONAPRISTONE INTERMEDIATES
    Publication number: 20170088579
    Abstract: Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 30, 2017
    Inventors: Ulf Tilstam, Stefan Proniuk, Holger Bindernagel, Silvia Werner, Holger Rauter
  • PURIFICATION OF EPIDAUNORUBICIN
    Publication number: 20170051001
    Abstract: A method for purifying epidaunorubicin is provided. The purification method involves the removal of the impurity epi-feudomycin, which is formed as a by-product in the biotechnological production of epidaunorubicin.
    Type: Application
    Filed: April 30, 2015
    Publication date: February 23, 2017
    Applicant: Medac Gesellschaft fur Klinische Spezialpraparate mbH
    Inventors: Holger BINDERNAGEL, Tero KUNNARI
  • Crystalline 4?-epidaunorubicin hydrochloride and use thereof
    Patent number: 9434756
    Abstract: 4?-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4?-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from C1 and C2 halogenated solvents and mixtures thereof, (b) solvent B selected from C1-C5 straight and branched alcohols and mixtures thereof, and (c) solvent C selected from C1-C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4?-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4?-epidaunorubicin hydrochloride is also provided.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: September 6, 2016
    Assignee: medac Gesellschaft für klinische Spezialpräparate mbH
    Inventors: Tero Kunnari, Holger Bindernagel, Sascha Weiser, Andrew Lupton, Stefan Wallert
  • CRYSTALLINE 4'-EPIDAUNORUBICIN HYDROCHLORIDE AND USE THEREOF
    Publication number: 20140357848
    Abstract: 4?-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4?-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from C1 and C2 halogenated solvents and mixtures thereof, (b) solvent B selected from C1-C5 straight and branched alcohols and mixtures thereof, and (c) solvent C selected from C1-C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4?-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4?-epidaunorubicin hydrochloride is also provided.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Inventors: Tero KUNNARI, Holger BINDERNAGEL, Sascha WEISER, Andrew LUPTON, Stefan WALLERT
  • Crystalline 4?-epidaunorubicin hydrochloride and use thereof
    Patent number: 8822658
    Abstract: 4?-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4?-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from C1 and C2 halogenated solvents and mixtures thereof, (b) solvent B selected from C1-C5 straight and branched alcohols and mixtures thereof, and (c) solvent C selected from C1-C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4?-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4?-epidaunorubicin hydrochloride is also provided.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: September 2, 2014
    Assignee: Heraeus Precious Metals GmbH & Co. KG
    Inventors: Tero Kunnari, Holger Bindernagel, Sascha Weiser, Andrew Lupton, Stefan Wallert
  • CRYSTALLINE 4?-EPIDAUNORUBICIN HYDROCHLORIDE AND USE THEREOF
    Publication number: 20140148587
    Abstract: 4?-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4?-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from C1 and C2 halogenated solvents and mixtures thereof, (b) solvent B selected from C1-C5 straight and branched alcohols and mixtures thereof, and (c) solvent C selected from C1-C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4?-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4?-epidaunorubicin hydrochloride is also provided.
    Type: Application
    Filed: February 4, 2014
    Publication date: May 29, 2014
    Applicant: HERAEUS PRECIOUS METALS GMBH & CO. KG
    Inventors: Tero KUNNARI, Holger BINDERNAGEL, Sascha WEISER, Andrew LUPTON, Stefan WALLERT
  • Crystallization of 4?-epidaunorubicin hydrochloride
    Patent number: 8686164
    Abstract: 4?-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4?-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from C1 and C2 halogenated solvents and mixtures thereof, (b) solvent B selected from C1-C5 straight and branched alcohols and mixtures thereof, and (c) solvent C selected from C1-C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4?-epidaunorubicin hydrochloride than solvent B.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: April 1, 2014
    Assignee: Heraeus Precious Metals GmbH & Co. KG
    Inventors: Tero Kunnari, Holger Bindernagel, Sascha Weiser, Andrew Lupton, Stefan Wallert
  • CRYSTALLIZATION OF 4'-EPIDAUNORUBICIN X HCI
    Publication number: 20120232291
    Abstract: 4?-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4?-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from C1 and C2 halogenated solvents and mixtures thereof, (b) solvent B selected from C1-C5 straight and branched alcohols and mixtures thereof, and (c) solvent C selected from C1-C5 straight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4?-epidaunorubicin hydrochloride than solvent B.
    Type: Application
    Filed: September 8, 2010
    Publication date: September 13, 2012
    Applicant: Heraeus Precious Metals GmbH & Co. KG
    Inventors: Tero Kunnari, Holger Bindernagel, Sascha Weiser, Andrew Lupton, Stefan Wallert