Patents by Inventor Holger Bittermann

Holger Bittermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240076276
    Abstract: The invention relates to a process for preparing 1,2?-benzisothiazoline-3-one according to formula (I), comprising the following steps: (a) reacting a 2-halogenbenzonitrile compound of general formula (II) with a reaction mixture, containing: (i) alkaline sulphide and/or alkaline hydrogen sulphide and (ii) an alkyl halide compound, represented by general formula (III): R1X (III) for producing an intermediate product of general formula (IV), and (b) reacting the intermediate product of general formula (V) obtained in step (a) with a halogenating agent or an oxidant and subsequent reaction of the 2-(alkylsulfoxy)benzonitrile with an acid to form 1,2-benzisothiazoline-3-one as well as a halide compound of general formula (V) R1X (V).
    Type: Application
    Filed: October 25, 2021
    Publication date: March 7, 2024
    Applicant: Thor GmbH
    Inventors: Rüdiger Baum, Holger Bittermann, Zhenghao Yang, Zhang Chaoqiang, Changhua Zhang, Qinglin Zheng, Ashraf Farouk
  • Publication number: 20230157295
    Abstract: The invention relates to an aqueous dispersion comprising the following components: (a) 25 to 60 wt. % of 3-iodo-2-propynyl butyl carbamate (IPBC), (b) 0.05 to 5 wt. % of at least one compound selected from the group consisting of methyl cellulose, hydroxyethyl cellulose, hydrophobically modified hydroxyethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl methyl cellulose and carboxymethyl cellulose, or mixtures of two or more of these, (c) 1 to 10 wt. % of at least one block copolymer based on ethylene oxide and propylene oxide, having a numerically defined average molecular weight of between 1,000 g/mol and 15,000 g/mol, (d) 0.1 to 10 wt. % of at least one thickener and/or anti-settling agent, and (e) up to 100 wt. % of water, in each case based on the total aqueous dispersion. The invention further relates to the use of this dispersion for the protection of technical materials from attack and/or destruction by microorganisms.
    Type: Application
    Filed: April 14, 2021
    Publication date: May 25, 2023
    Applicant: Thor GmbH
    Inventors: Rüdiger Baum, Holger Bittermann
  • Publication number: 20170334948
    Abstract: The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) L-(Sp)v-Ar1-Am-Ar2 ??(I) wherein L, SP, Ar1, AM, Ar2 and v are defined herein.
    Type: Application
    Filed: August 8, 2017
    Publication date: November 23, 2017
    Applicant: NOVALIX DEUTSCHLAND GMBH
    Inventors: Holger BITTERMANN, Marc ARNOLD, Thomas NEUMANN, Inge OTT, Kristina SCHMIDT, Renate SEKUL
  • Patent number: 9745339
    Abstract: The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) L-(Sp)v-Ar1—Am—Ar2?? (I) wherein L, SP, Ar1, AM, Ar2 and v are defined herein.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: August 29, 2017
    Assignee: NOVALIX DEUTSCHLAND GMBH
    Inventors: Holger Bittermann, Marc Arnold, Thomas Neumann, Inge Ott, Kristina Schmidt, Renate Sekul
  • Publication number: 20170152288
    Abstract: The present invention relates to the use for affinity purification of an antibody or a fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material.
    Type: Application
    Filed: February 14, 2017
    Publication date: June 1, 2017
    Applicant: NOVALIX DEUTSCHLAND GMBH
    Inventors: Holger BITTERMANN, Klaus BURKERT, Marc ARNOLD, Oliver KEIL, Thomas NEUMANN, Inge OTT, Kristina SCHMIDT, Daniel SCHWIZER, Renate SEKUL
  • Publication number: 20160009760
    Abstract: The present invention relates to the use, for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) L-(Sp)v-Ar1—Am—Ar2??(I) wherein L, SP, Ar1, AM, Ar2 and v are defined herein.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 14, 2016
    Applicant: GRAFFINITY PHARMACEUTICALS GMBH
    Inventors: Holger BITTERMANN, Marc ARNOLD, Thomas NEUMANN, Inge OTT, Kristina SCHMIDT, Renate SEKUL
  • Publication number: 20130131321
    Abstract: The present invention relates to the use for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) wherein Sp is a spacer group; v is 0 or 1; Am is an amide group —NR1—C(O)—, and wherein either NR1 is attached to Ar1 and —C(O)— is attached to Ar2, or —C(O)— is attached to Ar1 and NR1 is attached to Ar2; and R1 is hydrogen or C1 to C4 alkyl, preferably hydrogen or methyl; and more preferably hydrogen; Ar1 is a divalent 5- or 6-membered substituted or unsubstituted aromatic ring; Ar2 is 5- or 6-membered heterocyclic aromatic ring which is (a) attached to a further 5- or 6-membered aromatic ring via a single bond; or (b) fused to a further 5- or 6-membered aromatic ring as part of a multicyclic ring system; or (c) attached to at least one substituent selected from C1 to C4 alkyl; C2 to C4 alkenyl; C2 to C4 alkynyl; a
    Type: Application
    Filed: August 3, 2011
    Publication date: May 23, 2013
    Applicant: GRAFFINITY PHARMACEUTICALS GMBH
    Inventors: Holger Bittermann, Klaus Burkert, Marc Arnold, Oliver Keil, Thomas Neumann, Inge Ott, Kristina Schmidt, Daniel Schwizer, Renate Sekul