Patents by Inventor Holger C. Hansen
Holger C. Hansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5371080Abstract: Imidazoquinazoline compounds having the formula ##STR1## wherein Q is ##STR2## --COOR.sup.8 or --CN; wherein R.sup.1 is H, alkyl, unsubstituted or substituted cycloalkyl, alkoxy, alkoxyalkyl or CF.sub.3 ; R.sup.8 is alkyl; R.sup.2 and R.sup.3 independently are H, alkyl optionally substituted, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonylalkyl, formylalkyl, or an acetal thereof, or R.sup.2 and R.sup.3 together with the N-atom form a 4-6 membered monocyclic amino group in which ring system one or more of the carbon atoms may be exchanged with N, O or S, sulphinyl, sulphonyl or carbonyl or an acetal thereof, each of these ring systems optionally being substituted; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently are H, OH, halogen, CF.sub.3, NO.sub.2, NH.sub.2, CN, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl or alkoxycarbonyl.Type: GrantFiled: December 15, 1992Date of Patent: December 6, 1994Assignee: Novo Nordisk A/SInventors: Holger C. Hansen, Marit Kristiansen
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Patent number: 5276028Abstract: The heterocyclic compounds having the general formula I ##STR1## wherein R.sup.3 is ##STR2## wherein R' is H, C.sub.1-6 -alkyl or C.sub.3-7 -cycloalkyl; --B-- is --C(R").dbd.N-- or --N.dbd.C(R")-- wherein R" is a cyclic amine or --NR"'R"", wherein R"' and R"" independently are H,C.sub.1-6 -alkoxy, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkyl.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics and in improving the cognitive function of the brain of mammals.Type: GrantFiled: September 22, 1992Date of Patent: January 4, 1994Assignee: Nordisk A/SInventor: Holger C. Hansen
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Patent number: 5260298Abstract: Imidazotriazoloquinazoline compounds having the general formula ##STR1## wherein A together with the .alpha.-marked carbon atom and the .beta.-marked nitrogen atom is one of the groups ##STR2## cyano or CO.sub.2 R.sup.5, wherein R.sup.5 is H, alkyl, cycloalkyl, trifluoromethyl or alkoxymethyl; and R.sup.2, R.sup.3 and R.sup.4 independently are H, hydroxy, halogen, CN, alkyl, alkenyl, alkynyl, trifluoromethyl, alkoxy, dialkylaminoalkoxy, aralkoxy, aryloxy which may be substituted, acyclic amino group, or NR.sup.6 R.sup.7, wherein R.sup.6 and R.sup.7 independently are H or alkyl.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, antipsychotics, antiemetics, or in improving the cognitive function of the brain of mammals, or as benzodiazepine antagonsists.Type: GrantFiled: February 20, 1992Date of Patent: November 9, 1993Assignee: Novo Nordisk A/SInventor: Holger C. Hansen
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Patent number: 5116841Abstract: New imidazoquinoxaline compounds having the general formula I ##STR1## wherein ##STR2## wherein R.sup.1 and R.sup.2 independently are hydrogen, straight or branched C.sub.1-6 -alkyl, or C.sub.3-7 -cycloalkyl; R.sup.3 is hydrogen, straight or branched C.sub.1-6 -alkyl, straight or branched C.sub.2-6 -alkenyl, or aralkyl or aroylalkyl which may optionally be substituted with halogen or C.sub.1-6 -alkoxy; R.sup.4 amd R.sup.5 independently are hydrogen, halogen, C.sub.1-6 -alkyl or trifluoromethyl.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics and in improving the cognitive function of the brain of mammals.Type: GrantFiled: November 20, 1990Date of Patent: May 26, 1992Assignee: Novo Nordisk A/SInventors: Frank Watjen, Holger C. Hansen
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Patent number: 5102885Abstract: New imidazoquinoxaline compounds having the general formula I ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, straight or branched C.sub.1-6 -alkyl, or C.sub.3-7 -cycloalkyl; R.sup.3 is hydrogen, straight or branched C.sub.1-6 -alkyl, straight or branched C.sub.2-6 -alkenyl, or aralkyl or aroylalkyl which may optionally be substituted with halogen or C.sub.1-6 -alkoxy; R.sup.4 and R.sup.5 independently are hydrogen, halogen, C.sub.1-6 -alkyl or trifluoromethyl.The compounds are useful in psychopharmaceutical preparations as anticonvolusants, anxiolytics, hypnotics and in improving the cognitive function of the brain of mammals.Type: GrantFiled: November 20, 1990Date of Patent: April 7, 1992Assignee: Novo Nordisk A/SInventors: Frank Watjen, Holger C. Hansen
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Patent number: 5100895Abstract: New imidazoquinazoline compounds having the general formula ##STR1## wherein A together with the .alpha.-marked carbon atom and the .beta.-marked nitrogen atom is one of the groups ##STR2## wherein R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently are hydrogen, halogen C.sub.1-6 -alkyl, aryl or aralkylR.sup.1 is ##STR3## cyano or CO.sub.2 R.sup.8, wherein R.sup.8 is hydrogen, C.sub.1-6 -alkyl or C.sub.3-7 -cycloalkyl, trifluoromethyl or C.sub.1-6 -alkoxymethyl,R.sup.2 and R.sup.3 independently are hydrogen, halogen, CN, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.2-6 -alkynyl, trifluoromethyl, C.sub.1-6 -alkoxy, dialkylaminoalkoxy, aralkoxy, aryloxy which may be substituted with halogen or alkoxy, a cyclic amino group, or NR.sup.9 R.sup.10, wherein R.sup.9 and R.sup.10 independently are hydrogen or C.sub.1-6 -alkyl.Type: GrantFiled: September 5, 1990Date of Patent: March 31, 1992Assignee: Novo Nordisk A/SInventors: Holger C. Hansen, Marit Kristiansen
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Patent number: 5075304Abstract: New imidazoquinoxaline compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## or CO.sub.2 R' wherein R' isC.sub.3-7 -cycloalkyl;R.sup.5 is methyl, which is substituted with hydrogen, alkoxycarbonyl, heteroaryl, morpholino, C.sub.3-7 -cycloalkyl, C.sub.1-6 -alkenyl, arylacyl, alkylacyl, alkoxyalkyl, alkoxy, phthalimidophenyl, aralkyl or aryl, all of which are substituted with hydrogen, halogen, C.sub.1-6 -alkyl, amino, azido, or C.sub.1-6 -alkoxy;and R.sup.6 is H, C.sub.1-6 -alkyl, halogen, or CF.sub.3.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and in improving the cognitive function of the brain of mammals.Type: GrantFiled: May 18, 1989Date of Patent: December 24, 1991Assignee: Novo Nordisk A/SInventors: Holger C. Hansen, Frank Watjen
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Patent number: 5034530Abstract: New imidazoquinoxaline compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## wherein R' is C.sub.1-6 -alkyl, which may be straight or branched, C.sub.3-7 -cycloalkyl or phenyl; andR.sup.4 is hydrogen or C.sub.1-6 -alkyl; and 5-N-oxides thereof.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and in improving the cognitive function of the brain of mammals.Type: GrantFiled: June 8, 1989Date of Patent: July 23, 1991Assignee: Novo Nordisk A/SInventors: Holger C. Hansen, Frank Watjen
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Patent number: 4999354Abstract: New imidazoquinoxaline compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl; and--A-- is ##STR3## wherein R.sup.5 is hydrogen or halogen.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and in improving the cognitive function of the brain of mammals.Type: GrantFiled: January 3, 1990Date of Patent: March 12, 1991Assignee: A/S FerrosanInventors: Holger C. Hansen, Frank Watjen
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Patent number: 4999353Abstract: The invention relates to a dealkylation chemical process for preparing imidazoquinoxalines bearing hydrogen substitution in the five position, and to valuable pharm-intermediates of the formula I ##STR1## wherein ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl, phenyl, thienyl, or C.sub.1-3 -alkoxymethyland wherein R.sup.6 and R.sup.7 independently are hydrogen,halogen or CF.sub.3, used in that process. The intermediates also have anticonvulsant and anxiolytic properties.Type: GrantFiled: November 8, 1989Date of Patent: March 12, 1991Assignee: Novo Nordisk A/SInventors: Frank Watjen, Holger C. Hansen
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Patent number: 4968682Abstract: New imidazoquinoxaline compounds having the general formula ##STR1## wherein ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl; and ##STR3## wherein R.sup.5 is hydrogen or halogen. The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and in improving the cognitive function of the brain of mammals.Type: GrantFiled: December 7, 1988Date of Patent: November 6, 1990Assignee: A/S FerrosanInventors: Holger C. Hansen, Frank Watjen
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Patent number: 4902686Abstract: New heterocyclic compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## CO.sub.2 R' or CONR'R", wherein R' and R" independently are C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl;--A-- is --C(.dbd.O)--NR'"--, --NR'"--C(.dbd.O)--, or ##STR3## wherein R'" is C.sub.1-6 -alkyl; X is C or N; andR.sup.4 is hydrogen, halogen, CN, C.sub.1-6 -alkyl, C.sub.1-6 -alkynyl, trimethylsilyl-C.sub.1-6 -alkynyl, aryloxy which may be substituted with halogen, aralkoxy, C.sub.3-7 -cycloalkoxy which may be substituted with one or more C.sub.1-6 -alkyl groups, or NR""R'"", wherein R"" and R""' independently are C.sub.1-6 -alkyl or together with the nitrogen atom form a 3-7 membered heterocyclic ring.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and nootropics.Type: GrantFiled: April 20, 1989Date of Patent: February 20, 1990Assignee: A/S FerrosanInventors: Frank Watjen, Holger C. Hansen
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Patent number: 4873244Abstract: New heterocyclic compounds having the general formula ##STR1## wherein ##STR2## CO.sub.2 R' or CONR'R", whereinR' and R" independently are C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl;--A-- is --C(.dbd.O)--NR'"--, --NR'"--C(.dbd.O)--, or ##STR3## wherein R'" is C.sub.1-6 -alkyl;X is C or N; andR.sup.4 is hydrogen, halogen, CN, C.sub.1-6 -alkyl, C.sub.1-6 -alkynyl, trimethylsilyl-C.sub.1-6 -alkynyl, aryloxy which may be substituted with halogen, aralkoxy, C.sub.3-7 -cycloalkoxy which may be substituted with one or more C.sub.1-6 -alkyl groups, or NR""R'"", wherein R"" and R'"" independently are C.sub.1-6 -alkoxy or together with the nitrogen atom form a 3-7 membered heterocyclic ring.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and nootropics.Type: GrantFiled: February 16, 1988Date of Patent: October 10, 1989Assignee: A/S FerrosanInventors: WaFrank, Holger C. Hansen
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Patent number: 4866065Abstract: New heterocyclic compounds having the general formula ##STR1## wherein ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl;R.sup.4 is C.sub.1-6 -alkyl;--S-- is ##STR3## and wherein R.sup.5 and R.sup.6 independently are hydrogen, C.sub.1-6 -alkyl, or aryl.The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and in improving the cognitive function of the brain of mammals.Type: GrantFiled: October 6, 1988Date of Patent: September 12, 1989Assignee: A/S FerrosanInventors: Frank Watjen, Holger C. Hansen