Abstract: A technique for structuring a navigation data base in order to support incremental data updates is provided. A method implementation of the technique includes the steps of providing at least two data levels, wherein a first data level is associated with route links representing road segments of regional distance roads, partitioning the first data level into local tiles, wherein each local tile is associated with route links representing road segments of regional distance roads for a specific local geographic area, and interlinking those route links of neighboring local tiles that represent road segment portions of a regional distance road extending over neighboring local tiles.

Abstract: A technique of structuring a navigation database is provided, wherein the navigation database includes at least route link data for a predetermined geographic area. A method implementation of the technique includes organizing route link data associated with the predetermined geographic area into at least one routing cluster; providing the at least one routing cluster with a cluster identifier; and storing the at least one routing cluster together with the cluster identifier in the navigation database.

Abstract: The present invention relates to a method of modulating a chromatin binding protein or complex which binds to a functional group on an amino acid of a histone. This method involves phosphorylating or dephosphorylating a serine or threonine on the histone proximate to the amino acid under conditions effective to modulate the chromatin binding protein or complex. This method is particularly useful in treating or preventing cancer in a subject. In addition, the histone comprising a serine or threonine proximate to an amino acid capable of binding to a functional group can be used to screen for compounds which prevent or treat cancer. Also disclosed is an antibody or binding portion thereof raised against a binary switch on a histone comprising a phosphorylated serine or threonine proximate to an amino acid bound to a functional group and its use in detecting a condition mediated by that switch.

Abstract: The present invention relates to a method of modulating a chromatin binding protein or complex which binds to a functional group on an amino acid of a histone. This method involves phosphorylating or dephosphorylating a serine or threonine on the histone proximate to the amino acid under conditions effective to modulate the chromatin binding protein or complex. This method is particularly useful in treating or preventing cancer in a subject. In addition, the histone comprising a serine or threonine proximate to an amino acid capable of binding to a functional group can be used to screen for compounds which prevent or treat cancer. Also disclosed is an antibody or binding portion thereof raised against a binary switch on a histone comprising a phosphorylated serine or threonine proximate to an amino acid bound to a functional group and its use in detecting a condition mediated by that switch.