Patents by Inventor Holger Eickhoff
Holger Eickhoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220183341Abstract: A food manufacturing apparatus 100 for manufacturing a food product 1, in particular a meat or meat replacement product 1, in a 3D printing process, includes a movable carrier substrate 10 extending along a longitudinal substrate direction x and being configured for accommodating the food product 1, a deposition device 20 including a plurality of deposition modules 21, which are arranged along the longitudinal substrate direction x of the carrier substrate 10, wherein each deposition module 21 is arranged for depositing components of the food product 1 on the carrier substrate 10, a conveyor device 30 being arranged for moving the carrier substrate 10 along the longitudinal substrate direction x thereof relative to the deposition modules 21, and a collection device 40 being arranged for collecting the food product 1. Furthermore, a method of manufacturing a food product 1, in particular a meat or meat replacement product, is described.Type: ApplicationFiled: December 7, 2021Publication date: June 16, 2022Inventors: Holger EICKHOFF, Gusten DANIELSSON, Hector MARTINEZ, Erik GATENHOLM
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Patent number: 10199198Abstract: A method of electron microscopy imaging of samples, using an electron microscope (100) having a microscope column (10) and a transfer device (11) with a grid carriage (12), comprises the steps of preparing multiple samples (1) on a single electron microscopy grid (2), including dispensing the samples (1) with a dispenser device (30) on distinct positions on the grid (2), introducing the grid (1) with the transfer device (11) into the microscope column (10), and electron microscopy imaging of the samples (1), wherein the preparing step includes holding the grid (2) on the grid carriage (12) of the transfer device (11) or on a grid holder device (20) provided at the electron microscope (100) and dispensing the samples (1) on the grid (2) while holding it on the grid carriage (12) or on the grid holder device (20). Furthermore, an electron microscope (100) for electron microscopy imaging of samples is described.Type: GrantFiled: July 17, 2014Date of Patent: February 5, 2019Assignee: Scienion AGInventors: Claude Dufresne, Holger Eickhoff
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Publication number: 20170207062Abstract: A method of electron microscopy imaging of samples, using an electron microscope (100) having a microscope column (10) and a transfer device (11) with a grid carriage (12), comprises the steps of preparing multiple samples (1) on a single electron microscopy grid (2), including dispensing the samples (1) with a dispenser device (30) on distinct positions on the grid (2), introducing the grid (1) with the transfer device (11) into the microscope column (10), and electron microscopy imaging of the samples (1), wherein the preparing step includes holding the grid (2) on the grid carriage (12) of the transfer device (11) or on a grid holder device (20) provided at the electron microscope (100) and dispensing the samples (1) on the grid (2) while holding it on the grid carriage (12) or on the grid holder device (20). Furthermore, an electron microscope (100) for electron microscopy imaging of samples is described.Type: ApplicationFiled: July 17, 2014Publication date: July 20, 2017Inventors: Claude DUFRESNE, Holger EICKHOFF
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Publication number: 20170072417Abstract: A method of depositing at least one substance on a target substrate (1) comprises the step of operating at least one droplet dispenser (21) such that droplets (2) including the at least one substance are deposited on the target substrate (1), wherein the target substrate (1) has a substrate surface including spatially delimited receptacle sections (3) being arranged for accommodating the droplets (2), and the at least one droplet dispenser (21) is controlled in dependency on the locations of the receptacle sections (3) such that the droplets (2) are directed onto the receptacle sections (3). Furthermore, a dispenser device (100) for depositing at least one substance on a target substrate (1) is described.Type: ApplicationFiled: February 26, 2014Publication date: March 16, 2017Applicant: SCIENION AGInventors: Holger EICKHOFF, Guido BARED
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Publication number: 20150119296Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.Type: ApplicationFiled: December 23, 2014Publication date: April 30, 2015Inventors: Thomas C. Tisone, Holger Eickhoff
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Patent number: 8920752Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.Type: GrantFiled: February 1, 2013Date of Patent: December 30, 2014Assignee: Biodot, Inc.Inventors: Thomas C Tisone, Holger Eickhoff
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Patent number: 8889723Abstract: A method of treating inner ear hardness of hearing and restoring hearing of humans and animals after damage and loss of sensory hair cells in an organ of Corti based on regeneration biology includes administering a therapeutically effective amount of a compound including aminoalkyloxazole and aminoalkylthiazole carboxylic acid amides, or a pharmaceutically acceptable salt, a stereoisomer, a stereoisomer mixture, a tautomer or a prodrug compound thereof, directly or indirectly to damaged tissue structures in a cochlea, optionally, by transtympanal injection into a middle ear, by application to a round or oval window of an inner ear or by injection into the inner ear.Type: GrantFiled: March 13, 2014Date of Patent: November 18, 2014Assignee: EMC microcollections GmbHInventors: Holger Eickhoff, Hubert Lowenheim
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Publication number: 20140288135Abstract: A method of treating inner ear hardness of hearing and restoring hearing of humans and animals after damage and loss of sensory hair cells in an organ of Corti based on regeneration biology includes administering a therapeutically effective amount of a compound including aminoalkyloxazole and aminoalkylthiazole carboxylic acid amides, or a pharmaceutically acceptable salt, a stereoisomer, a stereoisomer mixture, a tautomer or a prodrug compound thereof, directly or indirectly to damaged tissue structures in a cochlea, optionally, by transtympanal injection into a middle ear, by application to a round or oval window of an inner ear or by injection into the inner ear.Type: ApplicationFiled: March 13, 2014Publication date: September 25, 2014Applicant: EMC microcollections GmbHInventors: Holger Eickhoff, Hubert Lowenheim
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Publication number: 20140213483Abstract: A microarray is disclosed comprising a reaction zone and a labeling zone, wherein the at least one labeling zone contains a marker, such as an alphanumerical code, a binary code, a barcode, a 2D code, a colour code or a triplet code and wherein the marker allows the identification of the microarray.Type: ApplicationFiled: July 27, 2012Publication date: July 31, 2014Inventors: Uwe Radelof, Joerg Hempel, Holger Eickhoff
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Patent number: 8614100Abstract: A method for depositing samples, in which at least one sample (10) is arranged on a substrate (30), comprises the following steps: positioning a sample dispenser (20) above the substrate (30), and actuating the sample dispenser (20) so that the sample (10) is moved from the sample dispenser (20) along a trajectory (11) to a predefined deposition position (32) on the substrate (30), wherein at least part of the trajectory (11) is shielded against electrical interference fields. Also described is a substrate (30) for receiving samples (10), comprising a substrate body (31), on the surface of which at least one deposition position (32) is provided, and a shielding electrode (40), which is designed so as to electrostatically shield the space above the at least one deposition position (32) against electrical interference fields.Type: GrantFiled: October 20, 2004Date of Patent: December 24, 2013Assignee: Scienion AGInventors: Eckhard Nordhoff, Alan Bullock, Christine Lubbert, Antonin Schenk, Holger Eickhoff, Martin Horn
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Publication number: 20130237443Abstract: A process for the production of a reaction chamber assembly, wherein a flat substrate and bottomless reaction chambers are provided, the substrate is first loaded with a biological agent and then the bottomless reaction chambers are bonded glue-free to the substrate, in particular through laser bonding, and liquid-tight reaction chambers, for instance individual wells, individually connected wells, such as strips, or wells in the form of a microtiter plate, are obtained. The present invention further provides a kit comprising a substrate suitable for being loaded with at least one biological agent and at least one bottomless reaction chamber, wherein the kit is suitable for glue-free bonding of the bottomless reaction chamber to the substrate.Type: ApplicationFiled: March 6, 2013Publication date: September 12, 2013Applicants: SCIENION AG, GREINER BIO-ONE GMBHInventors: Guenther KNEBEL, Holger EICKHOFF
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Publication number: 20130012514Abstract: Aminoalkyloxazole and aminoalkylthiazolecarboxylic acid amides of formulae (1) and (2) where X represents O or S, Y represents C or N, where the two atoms must be different from one another, R2 represents hydrogen or acyl and R1 and R3, which may be identical or different, represent a substituent selected from the group consisting of branched or straight-chain, substituted or unsubstituted alkyl groups, alkylcycloalkyl groups, alkylaryl groups, cycloalkyl groups, cycloalkylaryl groups, aryl groups and arylcycloalkyl groups which optionally contain heteroatoms, a pharmaceutically acceptable salt, a stereoisomer, a stereoisomer mixture, a tautomer or a prodrug compound, preferably a prodrug ester and a prodrug peptide, thereof.Type: ApplicationFiled: February 4, 2011Publication date: January 10, 2013Applicant: EMC microcollections GmbHInventors: Holger Eickhoff, Hubert Löwenheim
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Publication number: 20120312836Abstract: The invention relates to a microdispenser (1) for dispensing a liquid sample in a dispensing device, with a sample container (2) for receiving the liquid sample, and with a nozzle (7) for dispensing the sample located in the sample container (2). The microdispenser (1) with the filled sample container (2) can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container (2) during storage.Type: ApplicationFiled: August 22, 2012Publication date: December 13, 2012Applicant: SCIENION AGInventors: Holger EICKHOFF, Christian WURZEL
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Patent number: 8273307Abstract: The invention relates to a microdispenser (1) for dispensing a liquid sample in a dispensing device, with a sample container (2) for receiving the liquid sample, and with a nozzle (7) for dispensing the sample located in the sample container (2). The microdispenser (1) with the filled sample container (2) can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container (2) during storage.Type: GrantFiled: May 29, 2006Date of Patent: September 25, 2012Assignee: Scienion AGInventors: Holger Eickhoff, Christian Wurzel
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Publication number: 20120101008Abstract: A method for depositing samples, in which at least one sample (10) is arranged on a substrate (30), comprises the following steps: positioning a sample dispenser (20) above the substrate (30), and actuating the sample dispenser (20) so that the sample (10) is moved from the sample dispenser (20) along a trajectory (11) to a predefined deposition position (32) on the substrate (30), wherein at least part of the trajectory (11) is shielded against electrical interference fields. Also described is a substrate (30) for receiving samples (10), comprising a substrate body (31), on the surface of which at least one deposition position (32) is provided, and a shielding electrode (40), which is designed so as to electrostatically shield the space above the at least one deposition position (32) against electrical interference fields.Type: ApplicationFiled: October 20, 2004Publication date: April 26, 2012Inventors: Eckhard Nordhoff, Alan Bullock, Christine Lubbert, Antonin Schenk, Holger Eickhoff, Martin Horn
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Publication number: 20090060793Abstract: The invention relates to a microdispenser (1) for dispensing a liquid sample in a dispensing device, with a sample container (2) for receiving the liquid sample, and with a nozzle (7) for dispensing the sample located in the sample container (2). The microdispenser (1) with the filled sample container (2) can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container (2) during storage.Type: ApplicationFiled: May 29, 2006Publication date: March 5, 2009Applicant: SCIENION AGInventors: Holger Eickhoff, Christian Wurzel
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Publication number: 20090055100Abstract: The present invention relates to a method for identifying and/or characterizing a (poly)peptide comprising: (a) analyzing a peptide map of said (poly)peptide, comprising at least 1 peptide, and its peptide primary structure fingerprint by mass spectrometry; and (b) comparing data obtained in step (a) with a reference (poly)peptide database, said database comprising mass spectrometric data of peptide maps, comprising at least 1 peptide, and of its peptide primary structure fingerprint, of a (poly)peptide or of a variety of (poly)peptides.Type: ApplicationFiled: February 25, 2008Publication date: February 26, 2009Applicant: Max-Planck-Gesellschaft zur Forderung der Wissenschafter e.V.Inventors: Dolores Cahill, Eckhard Nordhoff, Joachim Klose, Holger Eickhoff, Frank Schmidt, Hans Lehrach
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Publication number: 20080227663Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.Type: ApplicationFiled: January 18, 2008Publication date: September 18, 2008Applicant: BioDot, Inc.Inventors: Thomas C. Tisone, Holger Eickhoff
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Patent number: 7105357Abstract: For processing of substances in the reservoir (3) of a microdroplet dosing device (1), movement of a solid carrier material with a binding-active surface takes place in the reservoir, and binding of the substance takes place on the surface of the carrier material which comprises magnetic particles (7) or a carrier pad.Type: GrantFiled: May 27, 1999Date of Patent: September 12, 2006Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e. V.Inventors: Markus Kalkum, Martin Müller, Eckhardt Nordhoff, Holger Eickhoff, Holger Rauth, Richard Reinhardt
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Patent number: 6991714Abstract: A sample taking apparatus comprises a plurality of separation tools (10) (for example, punching capillaries) on a holding device (20), wherein the separation tools (10) are each provided with actuating means (30) for separate control thereof. In a sample taking method (for example, for punching samples from separation gels), successively removed samples are deposited in parallel onto a target substrate.Type: GrantFiled: March 26, 1999Date of Patent: January 31, 2006Assignee: Max-Planck-Gesellschaft zur Foederung der Wissenschaften e.V.Inventors: Christine Gauss, Martin Horn, Markus Kalkum, Holger Eickhoff