Patents by Inventor Holger Eickhoff

Holger Eickhoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10199198
    Abstract: A method of electron microscopy imaging of samples, using an electron microscope (100) having a microscope column (10) and a transfer device (11) with a grid carriage (12), comprises the steps of preparing multiple samples (1) on a single electron microscopy grid (2), including dispensing the samples (1) with a dispenser device (30) on distinct positions on the grid (2), introducing the grid (1) with the transfer device (11) into the microscope column (10), and electron microscopy imaging of the samples (1), wherein the preparing step includes holding the grid (2) on the grid carriage (12) of the transfer device (11) or on a grid holder device (20) provided at the electron microscope (100) and dispensing the samples (1) on the grid (2) while holding it on the grid carriage (12) or on the grid holder device (20). Furthermore, an electron microscope (100) for electron microscopy imaging of samples is described.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: February 5, 2019
    Assignee: Scienion AG
    Inventors: Claude Dufresne, Holger Eickhoff
  • Publication number: 20170207062
    Abstract: A method of electron microscopy imaging of samples, using an electron microscope (100) having a microscope column (10) and a transfer device (11) with a grid carriage (12), comprises the steps of preparing multiple samples (1) on a single electron microscopy grid (2), including dispensing the samples (1) with a dispenser device (30) on distinct positions on the grid (2), introducing the grid (1) with the transfer device (11) into the microscope column (10), and electron microscopy imaging of the samples (1), wherein the preparing step includes holding the grid (2) on the grid carriage (12) of the transfer device (11) or on a grid holder device (20) provided at the electron microscope (100) and dispensing the samples (1) on the grid (2) while holding it on the grid carriage (12) or on the grid holder device (20). Furthermore, an electron microscope (100) for electron microscopy imaging of samples is described.
    Type: Application
    Filed: July 17, 2014
    Publication date: July 20, 2017
    Inventors: Claude DUFRESNE, Holger EICKHOFF
  • Publication number: 20170072417
    Abstract: A method of depositing at least one substance on a target substrate (1) comprises the step of operating at least one droplet dispenser (21) such that droplets (2) including the at least one substance are deposited on the target substrate (1), wherein the target substrate (1) has a substrate surface including spatially delimited receptacle sections (3) being arranged for accommodating the droplets (2), and the at least one droplet dispenser (21) is controlled in dependency on the locations of the receptacle sections (3) such that the droplets (2) are directed onto the receptacle sections (3). Furthermore, a dispenser device (100) for depositing at least one substance on a target substrate (1) is described.
    Type: Application
    Filed: February 26, 2014
    Publication date: March 16, 2017
    Applicant: SCIENION AG
    Inventors: Holger EICKHOFF, Guido BARED
  • Publication number: 20150119296
    Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 30, 2015
    Inventors: Thomas C. Tisone, Holger Eickhoff
  • Patent number: 8920752
    Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: December 30, 2014
    Assignee: Biodot, Inc.
    Inventors: Thomas C Tisone, Holger Eickhoff
  • Patent number: 8889723
    Abstract: A method of treating inner ear hardness of hearing and restoring hearing of humans and animals after damage and loss of sensory hair cells in an organ of Corti based on regeneration biology includes administering a therapeutically effective amount of a compound including aminoalkyloxazole and aminoalkylthiazole carboxylic acid amides, or a pharmaceutically acceptable salt, a stereoisomer, a stereoisomer mixture, a tautomer or a prodrug compound thereof, directly or indirectly to damaged tissue structures in a cochlea, optionally, by transtympanal injection into a middle ear, by application to a round or oval window of an inner ear or by injection into the inner ear.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 18, 2014
    Assignee: EMC microcollections GmbH
    Inventors: Holger Eickhoff, Hubert Lowenheim
  • Publication number: 20140288135
    Abstract: A method of treating inner ear hardness of hearing and restoring hearing of humans and animals after damage and loss of sensory hair cells in an organ of Corti based on regeneration biology includes administering a therapeutically effective amount of a compound including aminoalkyloxazole and aminoalkylthiazole carboxylic acid amides, or a pharmaceutically acceptable salt, a stereoisomer, a stereoisomer mixture, a tautomer or a prodrug compound thereof, directly or indirectly to damaged tissue structures in a cochlea, optionally, by transtympanal injection into a middle ear, by application to a round or oval window of an inner ear or by injection into the inner ear.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 25, 2014
    Applicant: EMC microcollections GmbH
    Inventors: Holger Eickhoff, Hubert Lowenheim
  • Publication number: 20140213483
    Abstract: A microarray is disclosed comprising a reaction zone and a labeling zone, wherein the at least one labeling zone contains a marker, such as an alphanumerical code, a binary code, a barcode, a 2D code, a colour code or a triplet code and wherein the marker allows the identification of the microarray.
    Type: Application
    Filed: July 27, 2012
    Publication date: July 31, 2014
    Inventors: Uwe Radelof, Joerg Hempel, Holger Eickhoff
  • Patent number: 8614100
    Abstract: A method for depositing samples, in which at least one sample (10) is arranged on a substrate (30), comprises the following steps: positioning a sample dispenser (20) above the substrate (30), and actuating the sample dispenser (20) so that the sample (10) is moved from the sample dispenser (20) along a trajectory (11) to a predefined deposition position (32) on the substrate (30), wherein at least part of the trajectory (11) is shielded against electrical interference fields. Also described is a substrate (30) for receiving samples (10), comprising a substrate body (31), on the surface of which at least one deposition position (32) is provided, and a shielding electrode (40), which is designed so as to electrostatically shield the space above the at least one deposition position (32) against electrical interference fields.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: December 24, 2013
    Assignee: Scienion AG
    Inventors: Eckhard Nordhoff, Alan Bullock, Christine Lubbert, Antonin Schenk, Holger Eickhoff, Martin Horn
  • Publication number: 20130237443
    Abstract: A process for the production of a reaction chamber assembly, wherein a flat substrate and bottomless reaction chambers are provided, the substrate is first loaded with a biological agent and then the bottomless reaction chambers are bonded glue-free to the substrate, in particular through laser bonding, and liquid-tight reaction chambers, for instance individual wells, individually connected wells, such as strips, or wells in the form of a microtiter plate, are obtained. The present invention further provides a kit comprising a substrate suitable for being loaded with at least one biological agent and at least one bottomless reaction chamber, wherein the kit is suitable for glue-free bonding of the bottomless reaction chamber to the substrate.
    Type: Application
    Filed: March 6, 2013
    Publication date: September 12, 2013
    Applicants: SCIENION AG, GREINER BIO-ONE GMBH
    Inventors: Guenther KNEBEL, Holger EICKHOFF
  • Publication number: 20130012514
    Abstract: Aminoalkyloxazole and aminoalkylthiazolecarboxylic acid amides of formulae (1) and (2) where X represents O or S, Y represents C or N, where the two atoms must be different from one another, R2 represents hydrogen or acyl and R1 and R3, which may be identical or different, represent a substituent selected from the group consisting of branched or straight-chain, substituted or unsubstituted alkyl groups, alkylcycloalkyl groups, alkylaryl groups, cycloalkyl groups, cycloalkylaryl groups, aryl groups and arylcycloalkyl groups which optionally contain heteroatoms, a pharmaceutically acceptable salt, a stereoisomer, a stereoisomer mixture, a tautomer or a prodrug compound, preferably a prodrug ester and a prodrug peptide, thereof.
    Type: Application
    Filed: February 4, 2011
    Publication date: January 10, 2013
    Applicant: EMC microcollections GmbH
    Inventors: Holger Eickhoff, Hubert Löwenheim
  • Publication number: 20120312836
    Abstract: The invention relates to a microdispenser (1) for dispensing a liquid sample in a dispensing device, with a sample container (2) for receiving the liquid sample, and with a nozzle (7) for dispensing the sample located in the sample container (2). The microdispenser (1) with the filled sample container (2) can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container (2) during storage.
    Type: Application
    Filed: August 22, 2012
    Publication date: December 13, 2012
    Applicant: SCIENION AG
    Inventors: Holger EICKHOFF, Christian WURZEL
  • Patent number: 8273307
    Abstract: The invention relates to a microdispenser (1) for dispensing a liquid sample in a dispensing device, with a sample container (2) for receiving the liquid sample, and with a nozzle (7) for dispensing the sample located in the sample container (2). The microdispenser (1) with the filled sample container (2) can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container (2) during storage.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: September 25, 2012
    Assignee: Scienion AG
    Inventors: Holger Eickhoff, Christian Wurzel
  • Publication number: 20120101008
    Abstract: A method for depositing samples, in which at least one sample (10) is arranged on a substrate (30), comprises the following steps: positioning a sample dispenser (20) above the substrate (30), and actuating the sample dispenser (20) so that the sample (10) is moved from the sample dispenser (20) along a trajectory (11) to a predefined deposition position (32) on the substrate (30), wherein at least part of the trajectory (11) is shielded against electrical interference fields. Also described is a substrate (30) for receiving samples (10), comprising a substrate body (31), on the surface of which at least one deposition position (32) is provided, and a shielding electrode (40), which is designed so as to electrostatically shield the space above the at least one deposition position (32) against electrical interference fields.
    Type: Application
    Filed: October 20, 2004
    Publication date: April 26, 2012
    Inventors: Eckhard Nordhoff, Alan Bullock, Christine Lubbert, Antonin Schenk, Holger Eickhoff, Martin Horn
  • Publication number: 20090060793
    Abstract: The invention relates to a microdispenser (1) for dispensing a liquid sample in a dispensing device, with a sample container (2) for receiving the liquid sample, and with a nozzle (7) for dispensing the sample located in the sample container (2). The microdispenser (1) with the filled sample container (2) can in this case be stored independently of and fluidically separately from the dispensing device, without the sample escaping from the sample container (2) during storage.
    Type: Application
    Filed: May 29, 2006
    Publication date: March 5, 2009
    Applicant: SCIENION AG
    Inventors: Holger Eickhoff, Christian Wurzel
  • Publication number: 20090055100
    Abstract: The present invention relates to a method for identifying and/or characterizing a (poly)peptide comprising: (a) analyzing a peptide map of said (poly)peptide, comprising at least 1 peptide, and its peptide primary structure fingerprint by mass spectrometry; and (b) comparing data obtained in step (a) with a reference (poly)peptide database, said database comprising mass spectrometric data of peptide maps, comprising at least 1 peptide, and of its peptide primary structure fingerprint, of a (poly)peptide or of a variety of (poly)peptides.
    Type: Application
    Filed: February 25, 2008
    Publication date: February 26, 2009
    Applicant: Max-Planck-Gesellschaft zur Forderung der Wissenschafter e.V.
    Inventors: Dolores Cahill, Eckhard Nordhoff, Joachim Klose, Holger Eickhoff, Frank Schmidt, Hans Lehrach
  • Publication number: 20080227663
    Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.
    Type: Application
    Filed: January 18, 2008
    Publication date: September 18, 2008
    Applicant: BioDot, Inc.
    Inventors: Thomas C. Tisone, Holger Eickhoff
  • Patent number: 7105357
    Abstract: For processing of substances in the reservoir (3) of a microdroplet dosing device (1), movement of a solid carrier material with a binding-active surface takes place in the reservoir, and binding of the substance takes place on the surface of the carrier material which comprises magnetic particles (7) or a carrier pad.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: September 12, 2006
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e. V.
    Inventors: Markus Kalkum, Martin Müller, Eckhardt Nordhoff, Holger Eickhoff, Holger Rauth, Richard Reinhardt
  • Patent number: 6991714
    Abstract: A sample taking apparatus comprises a plurality of separation tools (10) (for example, punching capillaries) on a holding device (20), wherein the separation tools (10) are each provided with actuating means (30) for separate control thereof. In a sample taking method (for example, for punching samples from separation gels), successively removed samples are deposited in parallel onto a target substrate.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: January 31, 2006
    Assignee: Max-Planck-Gesellschaft zur Foederung der Wissenschaften e.V.
    Inventors: Christine Gauss, Martin Horn, Markus Kalkum, Holger Eickhoff
  • Patent number: 6846398
    Abstract: In an electrophoresis device with numerous separation channels S loadable with samples, samples are loaded by applying samples in a shared injection channel I intersecting the separation channels S near a point where the injection channel I crosses one of the separation channels S. During exposure to a voltage in the injection channel, the samples are transferred to the separation channels S, and there electrophoretically separated.
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: January 25, 2005
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenshaften E.V.
    Inventors: Christoph Heller, Holger Eickhoff, Sven Behr