Abstract: The invention relates to agonistic TrkB binding molecules, methods for improving agonistic TrkB binders, their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Abstract: This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Abstract: Provided is an imaging method in which a surface of resected matter is imaged in first images with a photoacoustic image generation method down to a first predetermined depth such that in the first images there is a contrast between pathological tissue, in particular cancerous tissue, and non-pathological tissue.

Abstract: Among other things, a method for transporting radiation to a body region is described, wherein, in a first step, a canal is formed up to the body region to be irradiated and wherein, in a second step, an applicator (10) which is fitted to the diameter of the canal is introduced into the canal in order to guide a probe tip. Advantageously, applicator (10) is formed for use with a radiation therapy device for producing a defined radiation dose for irradiating a body region, whereby applicator (10) has a base body (11) with a foot region (12) for the uptake of at least one component of a radiation therapy device (30), a cylindrical guide region (13) connecting thereto for the uptake of a probe tip of a radiation therapy device, whereby a transition region (14) is formed between the foot region (12) and the guide region (13), as well as a head region (15), which is formed at the distal end (21) of base body (11). The method can be utilized especially for the treatment of tumors in the vertebral column.

Abstract: An applicator means (20) for radiation therapy, having at least one first applicator element for taking up a probe tip or a radiation source element (12) of a radiation source means (11), as well as a radiation therapy device (10) are described. In order to avoid an undesired slipping out of position of applicator means (20), particularly during the irradiation process, it is provided that the first applicator element is designed as an inner applicator element (21), which has a foot region (22), by means of which inner applicator element (21) can be attached to radiation source means (11), that applicator means (20) has a second applicator element which is designed as an outer applicator element (24) relative to inner applicator element (21), that outer applicator element (24) has an uptake space (28) for taking up at least one component of inner applicator element (21), and that inner applicator element (21) is designed so that it can be introduced into outer applicator element (24), at least in regions.

Abstract: Among other things, a method for transporting radiation to a body region is described, wherein, in a first step, a canal is formed up to the body region to be irradiated and wherein, in a second step, an applicator (10) which is fitted to the diameter of the canal is introduced into the canal in order to guide a probe tip. Advantageously, applicator (10) is formed for use with a radiation therapy device for producing a defined radiation dose for irradiating a body region, whereby applicator (10) has a base body (11) with a foot region (12) for the uptake of at least one component of a radiation therapy device (30), a cylindrical guide region (13) connecting thereto for the uptake of a probe tip of a radiation therapy device, whereby a transition region (14) is formed between the foot region (12) and the guide region (13), as well as a head region (15), which is formed at the distal end (21) of base body (11). The method can be utilized especially for the treatment of tumors in the vertebral column.

Abstract: A drape (101) for a surgical microscope (100) is attached to the surgical microscope (100) with a holding device (103) in the region of the surgical microscope main objective (104). The holding device (103) can accommodate a cover element (105). A tongue-shaped section is provided on the holding device (103) which applies a spring force to an outer peripheral surface of the surgical microscope main objective (104) when the holding device is arranged on the surgical microscope main objective (104) so that the holding device is held force-tight and friction-tight on the surgical microscope main objective. The cover element (105) can be inserted laterally into the holding device (103).

Abstract: A drape (101) for a surgical microscope (100) is attached to the surgical microscope (100) with a holding device (103) in the region of the surgical microscope main objective (104). The holding device (103) can accommodate a cover element (105). A tongue-shaped section is provided on the holding device (103) which applies a spring force to an outer peripheral surface of the surgical microscope main objective (104) when the holding device is arranged on the surgical microscope main objective (104) so that the holding device is held force-tight and friction-tight on the surgical microscope main objective. The cover element (105) can be inserted laterally into the holding device (103).

Abstract: A drape (101) for a surgical microscope (100) is attached to the surgical microscope (100) with a holding device (103) in the region of the surgical microscope main objective (104). The holding device (103) can accommodate a cover element (105). A tongue-shaped section is provided on the holding device (103) which applies a spring force to an outer peripheral surface of the surgical microscope main objective (104) when the holding device is arranged on the surgical microscope main objective (104) so that the holding device is held force-tight and friction-tight on the surgical microscope main objective. The cover element (105) can be inserted laterally into the holding device (103).

Abstract: A drape (101) for a surgical microscope (100) is attached to the surgical microscope (100) with a holding device (103) in the region of the surgical microscope main objective (104). The holding device (103) can accommodate a cover element (105). A tongue-shaped section is provided on the holding device (103) which applies a spring force to an outer peripheral surface of the surgical microscope main objective (104) when the holding device is arranged on the surgical microscope main objective (104) so that the holding device is held force-tight and friction-tight on the surgical microscope main objective. The cover element (105) can be inserted laterally into the holding device (103).

Abstract: Sorption agent and method for removing heavy metals from a gas containing heavy metal(s), with which a better removal rate of heavy metals from gases containing heavy metal(s) is made possible, and which can also be used in a broad temperature range. This is achieved in that the sorption agent contains at least one solid, which is a carrier material onto which at least one polysulfide is fixed and, in the case of the method, in which the gas containing heavy metal(s) is brought into contact with a sorption agent. A sorption agent is used that contains at least one solid, which is a carrier material onto which at least one polysulfide is fixed.

Abstract: Methods and apparatus for performing fluorescence and spatially resolved reflectance spectroscopy on a sample. A sample is irradiated with a fluorescence excitation fiber and radiation is collected from the sample with a fluorescence collection fiber and detected to form fluorescence spectra. The sample is also illuminated with a reflectance illumination fiber and reflected light from the sample is collected at a plurality of collection positions and detected to form spatially resolved reflectance spectra. The fibers may form a probe arranged in concentric sections. The spectra are analyzed by pre-processing and reducing the dimensionality of the spectral data.