Patents by Inventor Holger Hartmann

Holger Hartmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Bidirectional Catalase Promoter from Bacillus
    Publication number: 20240093211
    Abstract: The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 21, 2024
    Inventors: Max Fabian Felle, Stefan Jenewein, Kerstin Hage, Holger Hartmann
  • Method of increasing catalase expression or activity
    Patent number: 11788094
    Abstract: The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: October 17, 2023
    Assignee: BASF SE
    Inventors: Max Fabian Felle, Stefan Jenewein, Kerstin Hage, Holger Hartmann
  • NUCLEIC ACID ANALYSIS METHODS AND APPARATUS
    Publication number: 20230059334
    Abstract: The present invention is concerned with materials and methods for nucleic acid and/or protein analysis, including materials and methods for creating and/or analysing mutant libraries. The invention in particular relates to materials and methods for correlating a property of mutants of a target nucleic acid to the respective sequences of the mutants. The invention is particularly useful for analysing saturation mutagenesis libraries and the analysis of sensitivities to chemical or physical conditions, for example temperature stability and solvent stability, and for the analysis of production properties, for example yield or cellular localisation.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 23, 2023
    Inventors: Stefan Seemayer, Holger Hartmann
  • Method of producing proteins in filamentous fungi with decreased CLR2 activity
    Patent number: 11299522
    Abstract: The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: April 12, 2022
    Assignee: BASF SE
    Inventors: Stefan Haefner, Andreas Thywissen, Holger Hartmann, Nico Boehmer
  • METHOD OF PRODUCING PROTEINS IN FILAMENTOUS FUNGI WITH DECREASED CLR2 ACTIVITY
    Publication number: 20200308235
    Abstract: The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
    Type: Application
    Filed: December 2, 2016
    Publication date: October 1, 2020
    Inventors: Stefan Haefner, Andreas Thywissen, Holger Hartmann, Nico Boehmer
  • Recombinant microorganism for improved production of fine chemicals
    Patent number: 10731188
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: August 4, 2020
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • Method of producing proteins in filamentous fungi with decreased CLR1 activity
    Patent number: 10597429
    Abstract: The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: March 24, 2020
    Assignee: BASF SE
    Inventors: Stefan Haefner, Andreas Thywissen, Holger Hartmann, Nico Boehmer
  • Recombinant microorganism for improved production of fine chemicals
    Patent number: 10519474
    Abstract: Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: December 31, 2019
    Assignee: BASF SE
    Inventors: Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Hartwig Schroeder, Holger Hartmann, Markus Pompejus
  • RECOMBINANT MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS
    Publication number: 20190119710
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Application
    Filed: December 28, 2018
    Publication date: April 25, 2019
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • MODIFIED BIDIRECTIONAL CATALASE PROMOTER FROM BACILLUS
    Publication number: 20190112612
    Abstract: The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.
    Type: Application
    Filed: December 8, 2016
    Publication date: April 18, 2019
    Inventors: Max Fabian Felle, Stefan Jenewein, Kerstin Hage, Holger Hartmann
  • Recombinant microorganism for improved production of fine chemicals
    Patent number: 10208323
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: February 19, 2019
    Assignee: BASF SE
    Inventors: Hartwig Schroeder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • Recombinant microorganism for improved production of fine chemicals
    Patent number: 10208324
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: February 19, 2019
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Ratani, Zheyuan Guo, Markus Pompejus
  • METHOD OF PRODUCING PROTEINS IN FILAMENTOUS FUNGI WITH DECREASED CLR1 ACTIVITY
    Publication number: 20180354999
    Abstract: The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 13, 2018
    Inventors: Stefan Haefner, Andreas Thywissen, Holger Hartmann, Nico Boehmer
  • Recombinant microorganism for improved production of fine chemicals
    Patent number: 10047364
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 14, 2018
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Ratani, Zheyuan Guo, Markus Pompejus
  • RECOMBINANT MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS
    Publication number: 20180148748
    Abstract: Recombinant microorganism for improved production of fine chemicals The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Application
    Filed: June 2, 2016
    Publication date: May 31, 2018
    Inventors: Qingzhao WANG, Shakir Siraj RATANI, Zheyuan GUO, Hartwig SCHROEDER, Holger HARTMANN, Markus POMPEJUS
  • Genes and processes for the production of clavine-type alkaloids
    Patent number: 9828617
    Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: November 28, 2017
    Assignees: BASF SE, Evolva SA
    Inventors: Michael Naesby, Christophe Folly, Curt Aimé Friis Nielsen, Anaelle Hatsch, Markus Schwab, Oskar Zelder, Stefan Haefner, Hartwig Schroeder, Birgit Hoff, Andrea Molt, Klaus Ditrich, Michael Breuer, Holger Hartmann, Karsten Koerber
  • Gene cluster for biosynthesis of cornexistin and hydroxycornexistin
    Patent number: 9796992
    Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: October 24, 2017
    Assignee: BASF SE
    Inventors: Oskar Zelder, Birgit Hoff, Hartwig Schröder, Andrea Molt, Holger Hartmann, Klaus Ditrich, Michael Breuer, Rüdiger Reingruber, Jakob Weber
  • RECOMBINANT MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS
    Publication number: 20170211106
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Application
    Filed: December 8, 2014
    Publication date: July 27, 2017
    Applicant: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Ratani, Zheyuan Guo, Markus Pompejus
  • Gene cluster for biosynthesis of cornexistin and hydroxycornexistin
    Patent number: 9631212
    Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: April 25, 2017
    Assignee: BASF SE
    Inventors: Oskar Zelder, Birgit Hoff, Hartwig Schroeder, Andrea Molt, Holger Hartmann, Klaus Ditrich, Michael Breuer, Rüdiger Reingrubber, Jakob Weber
  • RECOMBINANT MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS
    Publication number: 20160355829
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Application
    Filed: September 11, 2014
    Publication date: December 8, 2016
    Applicant: BASF SE
    Inventors: Hartwig SCHRÖDER, Holger HARTMANN, Qingzhao WANG, Shakir RATANI, Zheyuan GUO, Markus POMPEJUS