Patents by Inventor Holger Hiemisch

Holger Hiemisch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel neuronally expressed protein and use thereof
    Publication number: 20050147967
    Abstract: The invention relates to novel specifically expressed proteins, and to nucleic acid sequences or recombinant nucleic acid constructs encoding said proteins. The invention further relates to host organisms or transgenic animals containing said nucleic acid sequences or recombinant nucleic acid constructs, and to monoclonal or polyclonal antibodies directed to the isolated proteins. The invention also relates to a method for finding substances having a specific binding affinity to the inventive proteins, and to a method for the qualitative or quantitative analysis of the inventive nucleic acid sequences or inventive proteins. The invention further relates to the use of the nucleic acid sequences and proteins.
    Type: Application
    Filed: April 17, 2001
    Publication date: July 7, 2005
    Inventors: Götz Bernhard, Brigitta Kammandel, Rohini Kuner, Sigrid Scheek, Holger Hiemisch
  • Novel endothelially expressed dnas and proteins, and their use
    Publication number: 20040260058
    Abstract: The present invention relates to novel, specifically expressed proteins and to nucleic acid sequences or transgenic nucleic acid constructs which encode the proteins.
    Type: Application
    Filed: June 3, 2004
    Publication date: December 23, 2004
    Inventors: Sigrid Scheek, Holger Hiemisch, Anthony Lanahan, Jean B. Regard, Paul F. Worley, Eckart Krupp, Markus Schwaninger, Nauder Faraday
  • Immediate early genes and methods of use therefor
    Publication number: 20040152658
    Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.
    Type: Application
    Filed: March 2, 2004
    Publication date: August 5, 2004
    Applicants: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, BASF-LYNX BIOSCIENCE AG, LYNX THERAPEUTICS, INC.
    Inventors: Paul F. Worley, Anthony Lanahan, Bernhard Goetz, Holger Hiemisch, Rohini Kuner, Sigrid Scheek, Karoly Nikolich, Eugene Zhukovsky
  • Immediate early genes and methods of use therefor
    Patent number: 6699660
    Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.
    Type: Grant
    Filed: February 5, 1999
    Date of Patent: March 2, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Paul F. Worley, Anthony Lanahan, Bernhard Goetz, Holger Hiemisch, Rohini Kuner, Sigrid Scheek, Karoly Nikolich, Eugene Zhukovsky
  • Constant length signatures for parallel sequencing of polynucleotides
    Publication number: 20040002104
    Abstract: Methods are disclosed for producing solid phase cloned libraries of oligonucleotide tag-DNA signature sequence constructs, in which the DNA signature components are all of the same length. Such libraries are especially useful for large-scale parallel sequencing of DNA signature sequences prepared from a source population, such as mRNA or genomic DNA.
    Type: Application
    Filed: April 25, 2003
    Publication date: January 1, 2004
    Inventors: Achim Fischer, Holger Hiemisch, Steven Williams, Sydney Brenner, Roger Walker, Eric Vermaas, Rongdian Fu
  • IMMEDIATE EARLY GENES AND METHODS OF USE THEREFOR
    Publication number: 20030203840
    Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.
    Type: Application
    Filed: February 5, 1999
    Publication date: October 30, 2003
    Inventors: PAUL F. WORLEY, ANTHONY LANAHAN, BERNHARD GOETZ, HOLGER HIEMISCH, ROHINI KUNER, SIGRID SCHEEK, KAROLY NIKOLICH, EUGENE ZHUKOVSKI