Patents by Inventor Holger Klapproth

Holger Klapproth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210017582
    Abstract: Methods of identifying homologous genomic sequences that may be present in a sample utilizing virtual probes, arrays for distinguishing homologous genomic sequences, systems for distinguishing homologous genomic sequences, and probe molecules useful in the methods, arrays, and systems of the disclosure.
    Type: Application
    Filed: April 3, 2020
    Publication date: January 21, 2021
    Applicant: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Publication number: 20200308629
    Abstract: The disclosure provides an asymmetric PCR amplification method for preparation of single-stranded product and primers and kits useful therefor.
    Type: Application
    Filed: November 21, 2018
    Publication date: October 1, 2020
    Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.
    Inventors: Nicolaas SMIT, Sonja BEDNAR, Holger KLAPPROTH, Kevin BOYNTON
  • Publication number: 20200261880
    Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Application
    Filed: December 16, 2016
    Publication date: August 20, 2020
    Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.
    Inventors: Holger Klapproth, Sonja BEDNAR
  • Patent number: 10746654
    Abstract: In a method for monitoring the correspondence of a beer sample with a reference beer, at least 15 reference beer samples of the reference beer are brewed with the same ingredients and the same process parameters. Measurement signals for the absorption spectrum of the reference beer samples are captured and a principal component analysis is carried out for the measurement signals, in which at least 15 principal components are ascertained. A factor loading PR(i,j) is respectively determined for each principal component for the individual reference beer samples and a reference value (I) is ascertained, where i denotes the reference beer sample and j denotes the principal component, ?R(j) refers to the mean value of all factor loadings of the j-th principal component and ?P(j) refers to the standard deviation of these factor loadings.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: August 18, 2020
    Assignee: QFood GmbH
    Inventors: Holger Klapproth, Robert Seidel, Joachim Haas, Jonathan E. Green
  • Publication number: 20200209246
    Abstract: The present invention relates to the field of production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to diagnostic procedures using them in the diagnosis of cancers, in particular malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.
    Type: Application
    Filed: July 5, 2018
    Publication date: July 2, 2020
    Inventors: Ulrich BIRSNER, Hassan JUMAA, Holger KLAPPROTH, Marc A. KESSEMEIER
  • Publication number: 20200199225
    Abstract: The present invention relates to the field of the production, identification and selection of biological binding molecules such as antibodies or fragments thereof, as well as to their use in the therapy and prophylaxis of cancer diseases, such as, in particular, malignant B-cell neoplasia. The binding molecules are able to selectively bind to autonomously active or autonomously activated B-cell receptors, the autonomously active or autonomously activated B-cell receptors being characterized by the presence of structural domains to which the binding molecule selectively binds and which are responsible for the autonomously active or autonomously activated state of the B-cell receptors.
    Type: Application
    Filed: July 5, 2018
    Publication date: June 25, 2020
    Inventors: Ulrich BIRSNER, Hassan JUMAA, Holger KLAPPROTH, Marc A. KESSEMEIER
  • Patent number: 10513730
    Abstract: The disclosure provides an asymmetric PCR amplification method for preparation of single-stranded product and primers and kits useful therefor.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: December 24, 2019
    Assignee: Safeguard Biosystems Holdings Ltd.
    Inventors: Nicolaas Smit, Sonja Bednar, Holger Klapproth, Kevin Boynton
  • Patent number: 10444212
    Abstract: In a method for determining the concentration of glucoraphanin in a plant a sample of the plant is contacted by a polar uncharged organic solvent and comminuted such that glucoraphanin and plant material contained in the sample are dissolved in the solvent and, after removal of undissolved plant parts, the extract formed thereby is subjected to an UV-absorption measurement wherein for a first wavelength range of 200-270 nm, an absorption signal is recorded. A second derivative of the absorption signal is then obtained for a second wavelength range of 240-250 nm and the value of the minimum of the second derivative is determined and, based on this value, a concentration value for the glucoraphanin in the plant is established.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: October 15, 2019
    Assignees: QFOOD GMBH, SMAAK MAKER HOLDING B.V.
    Inventors: Sonja Bednar, Holger Klapproth, Robert Seidel
  • Publication number: 20190301981
    Abstract: A sampling device for taking beverage samples from a beverage line containing a gaseous beverage under pressure comprises a connection for the beverage line, a pump having a compressible and expandable pump chamber, a particle filter, a discharging opening for the beverage sample, an outlet opening for waste, a control device and a line system which has adjustable valves and is connected to the pump chamber, to the connection for the beverage line, to the particle filter, to the discharging opening and to the outlet opening.
    Type: Application
    Filed: June 8, 2017
    Publication date: October 3, 2019
    Applicant: QFood GmbH
    Inventors: Robert Seidel, Holger Klapproth, Martina Auerswald
  • Publication number: 20190211159
    Abstract: The disclosure provides three-dimensional cross-linked polymer networks transport channels, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 11, 2019
    Applicant: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Publication number: 20190178794
    Abstract: In a method for monitoring the correspondence of a beer sample with a reference beer, at least 15 reference beer samples of the reference beer are brewed with the same ingredients and the same process parameters. Measurement signals for the absorption spectrum of the reference beer samples are captured and a principal component analysis is carried out for the measurement signals, in which at least 15 principal components are ascertained. A factor loading PR(i,j) is respectively determined for each principal component for the individual reference beer samples and a reference value (I) is ascertained, where i denotes the reference beer sample and j denotes the principal component, ?R(j) refers to the mean value of all factor loadings of the j-th principal component and ?P(j) refers to the standard deviation of these factor loadings.
    Type: Application
    Filed: August 3, 2017
    Publication date: June 13, 2019
    Inventors: Holger Klapproth, Robert Seidel, Joachim Haas, Jonathan E. Green
  • Publication number: 20190153508
    Abstract: The disclosure provides an asymmetric PCR amplification method for preparation of single-stranded product and primers and kits useful therefor.
    Type: Application
    Filed: November 22, 2017
    Publication date: May 23, 2019
    Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.
    Inventors: Nicolaas SMIT, Sonja BEDNAR, Holger KLAPPROTH, Kevin BOYNTON
  • Patent number: 10273336
    Abstract: The disclosure provides three-dimensional cross-linked polymer networks transport channels, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: April 30, 2019
    Assignee: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.
    Inventors: Holger Klapproth, Sonja Bednar
  • Publication number: 20180362719
    Abstract: The disclosure provides three-dimensional cross-linked polymer networks transport channels, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Application
    Filed: June 19, 2018
    Publication date: December 20, 2018
    Applicant: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Publication number: 20180305740
    Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 25, 2018
    Applicant: SAFEGUARD BIOSYSTEMS HOLDINGS LTD.
    Inventors: Holger KLAPPROTH, Nicolaas SMIT
  • Patent number: 10036054
    Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: July 31, 2018
    Assignee: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Nicolaas Smit
  • Patent number: 9914961
    Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: March 13, 2018
    Assignee: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Publication number: 20170356035
    Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Application
    Filed: June 23, 2017
    Publication date: December 14, 2017
    Applicant: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Patent number: 9738926
    Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: August 22, 2017
    Assignee: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Sonja Bednar
  • Publication number: 20170218356
    Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids.
    Type: Application
    Filed: February 14, 2017
    Publication date: August 3, 2017
    Applicant: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger KLAPPROTH, Nicolaas SMIT