Patents by Inventor Holger Kuehne

Holger Kuehne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL PYRROLIDINE DERIVATIVES
    Publication number: 20120115843
    Abstract: The invention relates to a compound of formula (I) wherein A1 to A4 and R1 to R6 are defined as in the description and in the claims. The compound of formula (I) can be used, for example, as inhibitors of the cysteine protease cathepsin.
    Type: Application
    Filed: October 24, 2011
    Publication date: May 10, 2012
    Inventors: David Banner, Uwe Grether, Wolfgang Haap, Holger Kuehne, Harald Mauser, Jean-Marc Plancher
  • Proline derivatives
    Patent number: 8163793
    Abstract: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: April 24, 2012
    Assignee: Hoffman-La Roche Inc.
    Inventors: Rubén Alvarez Sánchez, David Banner, Simona M. Ceccarelli, Uwe Grether, Wolfgang Haap, Peter Hartman, Guido Hartmann, Hans Hilpert, Holger Kuehne, Harald Mauser, Jean-Marc Plancher
  • Sulfonamide derivatives
    Patent number: 7964633
    Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: June 21, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Haap, Paul Hebeisen, Eric A. Kitas, Philipp Christoph Kohler, Holger Kuehne, Armin Ruf
  • Aza-pyridopyrimidinone derivatives
    Patent number: 7928106
    Abstract: The invention is concerned with novel aza-pyridopyrimidinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, X1, X2, X3, Y, Z, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used in treating or preventing diseases which are modulated by HM74A agonists.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: April 19, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Aurelia Conte, Henrietta Dehmlow, Uwe Grether, Nicole A. Kratochwil, Holger Kuehne, Robert Narquizian, Constantinos G. Panousis, Jens-Uwe Peters, Fabienne Ricklin
  • Cyclopentane derivatives
    Patent number: 7893099
    Abstract: The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: February 22, 2011
    Assignee: Hoffman-La Roche Inc.
    Inventors: David Banner, Simona M. Ceccarelli, Uwe Grether, Wolfgang Haap, Hans Hilpert, Holger Kuehne, Harald Mauser, Jean-Marc Plancher, Ruben Alvarez Sanchez
  • NOVEL CYCLOPENTANE DERIVATIVES
    Publication number: 20100317647
    Abstract: The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 16, 2010
    Inventors: David Banner, Simona M. Ceccarelli, Uwe Grether, Wolfgang Haap, Hans Hilpert, Holger Kuehne, Harald Mauser, Jean-Marc Plancher, Rubén Alvarez Sánchez
  • NOVEL PROLINE DERIVATIVES
    Publication number: 20100267722
    Abstract: The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: April 16, 2010
    Publication date: October 21, 2010
    Inventors: Rubén Alvarez Sánchez, David Banner, Simona M. Ceccarelli, Uwe Grether, Wolfgang Haap, Peter Hartman, Guido Hartmann, Hans Hilpert, Holger Kuehne, Harald Mauser, Jean-Marc Plancher
  • DPP IV inhibitors
    Patent number: 7803819
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: September 28, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Michael Loeffler, Ramakanth Sarabu, Hans Peter Wessel
  • Heteroaryl and benzyl amide compounds
    Patent number: 7745477
    Abstract: Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: June 29, 2010
    Assignee: Hoffman-La Roche Inc.
    Inventors: Aurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
  • NOVEL COMPOUNDS
    Publication number: 20100160441
    Abstract: The invention is concerned with compounds of formula I: wherein R, R2, and Q are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are useful as inhibitors of cholesteryl ester transfer protein (CETP).
    Type: Application
    Filed: December 7, 2009
    Publication date: June 24, 2010
    Inventors: Torsten Hoffmann, Holger Kuehne, Eric J. Niesor, Philippe Pflieger
  • SALT AND POLYMORPH OF A DPP-IV INHIBITOR
    Publication number: 20100093808
    Abstract: The invention is concerned with (2S)-1-{[1,1-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propylamino]-acetyl}-pyrrolidine-2-carbonitrile fumarate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
    Type: Application
    Filed: December 14, 2009
    Publication date: April 15, 2010
    Inventors: André Bubendorf, Olaf Grassmann, Daniel Hunziker, Holger Kuehne, Regina Moog, Urs Schwitter
  • Heterobicyclic amide compounds
    Patent number: 7691876
    Abstract: Compounds of formula I processes for their preparation and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: April 6, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Philippe Pflieger, Michelangelo Scalone
  • Anthranilamide and 2-amino-heteroarene-carboxamide compounds
    Patent number: 7678818
    Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: January 19, 2007
    Date of Patent: March 16, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Aurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
  • Heteroaryl and benzyl amide compounds
    Patent number: 7674815
    Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: March 9, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christoph Faeh, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Philippe Pflieger
  • Heteroaryl carboxamide compounds
    Patent number: 7572823
    Abstract: Compounds of formula I their manufacture, pharmaceutical compositions containing them and their use as medicaments.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: August 11, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Aurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
  • Pyridopyrimidinone derivatives which are HM74A agonists
    Patent number: 7572801
    Abstract: The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the present invention are HM74A agonists with improved properties compared to niacin and can be used for the treatment and/or prevention of diseases such as dyslipidemia, atherosclerosis, diabetes, metabolic syndrome, and other related diseases associated with HM74A.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: August 11, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Aurelia Conte, Henrietta Dehmlow, Uwe Grether, Nicole A. Kratochwil, Holger Kuehne, Robert Narquizian, Constantinos Panousis, Jens-Uwe Peters, Fabienne Ricklin, Stephan Roever
  • NOVEL AZA-PYRIDOPYRIMIDINONE DERIVATIVES
    Publication number: 20080234277
    Abstract: The invention is concerned with novel aza-pyridopyrimidinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, X1, X2, X3, Y, Z, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used in treating or preventing diseases which are modulated by HM74A agonists.
    Type: Application
    Filed: March 17, 2008
    Publication date: September 25, 2008
    Inventors: Aurelia Conte, Henrietta Dehmlow, Uwe Grether, Nicole A. Kratochwil, Holger Kuehne, Robert Narquizian, Constantinos G. Panousis, Jens-Uwe Peters, Fabienne Ricklin
  • Sulfonamide derivatives
    Publication number: 20080085928
    Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: September 24, 2007
    Publication date: April 10, 2008
    Inventors: Wolfgang Haap, Paul Hebeisen, Eric Kitas, Philipp Kohler, Holger Kuehne, Armin Ruf
  • DPP IV inhibitors
    Patent number: 7314884
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: January 1, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Michael Loeffler, Ramakanth Sarabu, Hans Peter Wessel
  • Novel pyridopyprimidinone derivatives which are HM74A agonists
    Publication number: 20070275987
    Abstract: The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the present invention are HM74A agonists with improved properties compared to niacin and can be used for the treatment and/or prevention of diseases such as dyslipidemia, atherosclerosis, diabetes, metabolic syndrome, and other related diseases associated with HM74A.
    Type: Application
    Filed: May 11, 2007
    Publication date: November 29, 2007
    Inventors: Aurelia Conte, Henrietta Dehmlow, Uwe Grether, Nicole A. Kratochwil, Holger Kuehne, Robert Narquizian, Constantinos Panousis, Jens-Uwe Peters, Fabienne Ricklin, Stephan Roever